Day: September 18, 2020

22795-99-9, (S)-(1-Ethylpyrrolidin-2-yl)methanamine is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

22795-99-9, To a mixture of cyanuric chloride (0.368 g, 2 mmol) in CH3CN at approximately -10 to -20 C. was added 3-fluoro-p-anisidine (0.28 g, 2 mmol) in CH3CN followed by the addition of N,N-diisopropylethylamine (DIEA) (0.35 mL, 2 mmol) and stirred for an hour. The reaction mixture was then allowed to reach room temperature for an hour. The second step was continued without further purification. Cycloheptylamine (0.25 mL, 2 mmol) and DIEA (0.35 mL, 2 mmol) were added and the reaction mixture was stirred overnight at rt. The third step was also preceded without any further purification. S-(-)-2-aminomethyl-N-ethyl pyrrolidine (0.29 mL, 2 mmol) and DIEA (0.35 mL, 2 mmol) were added and the reaction mixture was refluxed overnight. The reaction mixture was diluted with ethyl acetate and washed with brine. The organic layer was separated and dried over potassium carbonate, filtered, and concentrated under reduced pressure affording 0.920 g crude material. The crude material was purified by column chromatography to yield a white solid 139 (0.550 g, 60%), mp 75-77 C.; HPLC: Inertsil ODS-3V C18, 40:30:30 [KH2PO4 (0.01M, pH 3.2): CH3OH: CH3CN], 264 nm, Rt 7.9 min, 95.9% purity; MS (ESI): m/z 458 (M+H, 100).

22795-99-9 (S)-(1-Ethylpyrrolidin-2-yl)methanamine 643457, achiral-catalyst compound, is more and more widely used in various fields.

Reference£º
Patent; Timmer, Richard T.; Alexander, Christopher W.; Pillarisetti, Sivaram; Saxena, Uday; Yeleswarapu, Koteswar Rao; Pal, Manojit; Reddy, Jangalgar Tirupathy; Krlshna Reddy, Velagala Venkata Rama Murali; Sridevi, Bhatlapenumarthy Sesha; Kumar, Potlapally Rajender; Reddy, Gaddam Om; US2004/209880; (2004); A1;,
Chiral Catalysts
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94-91-7,94-91-7, N,N’-Bis(salicylidene)-1,2-propanediamine is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a round-bottomed flask with a stir bar was placed with [Ru(PPh3)3Cl2] (868 mg, 2.0 mmol) under the nitrogen. Pre-dried THF(10 mL) was added and the resulting mixture was stirred at room temperature. Then salen-enH2 (536 mg, 2.0 mmol) and a little excess of Et3N (252 mg, 2.5 mmol) in THF (5 mL) were added. The reaction mixture was stirred at room temperature overnight. After removal of solvents, CH2Cl2 (15 mL) was added and the solution was filtered through cilite. The filtrate was concentrated and the residue was washed with Et2O (5mL 2) and hexane (5 mL 2) to give the desired product. Recrystallization from CH2Cl2/Et2O (1:2) afforded green block-shaped crystals of [RuCl(PPh3)(salen)] (3) suitable for X-ray diffraction in three days. Yield: 1011 mg, 76% (based on Ru).

The synthetic route of 94-91-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Tang, Li-Hua; Wu, Fule; Lin, Hui; Jia, Ai-Quan; Zhang, Qian-Feng; Inorganica Chimica Acta; vol. 477; (2018); p. 212 – 218;,
Chiral Catalysts
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1,3-Dimethyl-1H-benzo[d]imidazol-3-ium iodide, cas is 7181-87-5, it is a common heterocyclic compound, the chiral-catalyst compound, its synthesis route is as follows.,7181-87-5

Additions: [0291] 0.6 gram of a Karstedt solution containing 16.2% platinum, i.e. 0.5 mmol of platinum, [0292] 137 mg of N,N-dimethylbenzimidazolium iodide, i.e. 0.5 mmol (1. 0 equiv.) (A,B,T3,T4=benzyl; T1T2=methyl), [0293] 112 mg of potassium tert-butoxide, i.e. 1 mmol (2 equiv.) [0294] 20 ml of dry THF. [0295] The solution of the Karstedt complex and the benzimidazolium salt are placed in the round-bottomed flask and then diluted in 20 ml of THF. The potassium tert-butoxide is added at room temperature and the mixture is stirred for 36 hours in the absence of light. The reaction medium is diluted in dichloromethane and then washed with water. The solvent is evaporated off and the oil obtained is rapidly filtered through silica gel (eluent: CH2Cl2). After evaporating off the solvent, the solid obtained is rinsed with two milliliters of hexamethyldisiloxane. 173 mg (66% yield) of an analytically pure white solid are obtained.

With the rapid development of chemical substances, we look forward to future research findings about 1,3-Dimethyl-1H-benzo[d]imidazol-3-ium iodide

Reference£º
Patent; Buisine, Olivier; Marko, Istvan; Sterin, Sebastien; US2004/198996; (2004); A1;,
Chiral Catalysts
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(S)-(1-Ethylpyrrolidin-2-yl)methanamine, cas is 22795-99-9, it is a common heterocyclic compound, the chiral-catalyst compound, its synthesis route is as follows.,22795-99-9

General procedure: (2-(7-Aza-1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate), (HATU) (1.2 equivalents) was added to a solution of acid (1 equivalent), the appropriate amine (1.5 equivalents) and DIEA (2 equivalents) in dry acetonitrile (10 mL) at room temperature under argon atmosphere. The reaction mixture was stirred at room temperature for 1-2 h. Solvent was evaporated under reduced pressure and the crude product was purified using a Teledyne Isco Combiflash Rf purification machine to provide the desired amide in excellent yield.

As the rapid development of chemical substances, we look forward to future research findings about 22795-99-9

Reference£º
Article; Mathew, Bini; Hobrath, Judith V.; Connelly, Michele C.; Kiplin Guy; Reynolds, Robert C.; Bioorganic and Medicinal Chemistry Letters; vol. 27; 20; (2017); p. 4614 – 4621;,
Chiral Catalysts
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(S)-2-(Methoxymethyl)pyrrolidine, cas is 63126-47-6, it is a common heterocyclic compound, the chiral-catalyst compound, its synthesis route is as follows.,63126-47-6

Method B Methyl bromoacetate (199 pI, 2.10 mmol) was added to a mixture of (S)-2- methoxymethyl pyrrolidine (268 pI, 2.17 mmol), potassium carbonate (319 mg, 2.31 mmol) and sodium iodide (315 mg, 2.10 mmol) in acetonitrile (3 ml). The mixture was subjected to microwave irradiation for 5 min at 160¡ãC, then partitioned between dichloromethane and water. The aqueous layer was extracted with dichloromethane and the combined organic layers were washed with brine, dried over sodium sulfate and concentrated in vacuo. Purification by flash column chromatography eluting with 0-10percent (v/v) methanol in dichloromethane afforded (S)- (2-methoxymethyl-pyrrolidin-1- yl) acetic acid methyl ester (133 mg, 0.71 mmol).

As the rapid development of chemical substances, we look forward to future research findings about 63126-47-6

Reference£º
Patent; AKZO NOBEL N.V.; WO2005/89754; (2005); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare

(R)-2′-amino-[1,1′-binaphthalen]-2-ol, cas is 137848-28-3, it is a common heterocyclic compound, the chiral-catalyst compound, its synthesis route is as follows.,137848-28-3

To a magnetically stirred solution of R-(+)-2-amino-1,1′-binaphthalen-2-ol (0.215g, 0.753mmol) in DMAC (15mL) was slowly added a solution of trans- 1 (0.116 g, 0.378 mmol) in DMAC (10 mL). After the addition was complete, the reaction mixture was stirred in the dark at room temperature for 24 h and then poured into water (300 mL), giving an orange precipitate. The solid was collected by filtration and was then dissolved in CHCl3 (250 mL) and washed with water (3¡Á100 mL) and brine (50 mL). The organic phase was dried over anhydrous sodium sulfate and then concentrated in vacuo to furnish monomer trans-2RR (87% yield) as a bright orange powder. M.p.: >250C (decomposition). 1H NMR (DMSO-d6, 500MHz) delta 9.87 (s, 2H), 9.10 (s, 2H), 8.24-8.28 (m, 2H), 8.13-8.18 (m, 2H), 8.07-8.10 (m, 2H), 8.00-8.05 (m, 2H), 7.93-7.96 (m, 2H), 7.81-7.86 (m, 4H), 7.52-7.59 (m, 6H), 7.46-7.50 (m, 2H), 7.34-7.40 (m, 2H), 7.29-7.33 (m, 2H), 7.20-7.26 (m, 4H), 6.97-7.03 (m, 2H); MS m/e: 805.28 ([M]H+); [alpha]D=(+)207 (c=0.076g/dL, THF).

As the rapid development of chemical substances, we look forward to future research findings about 137848-28-3

Reference£º
Article; Lynch, Joseph G.; Jaycox, Gary D.; Polymer; vol. 55; 16; (2014); p. 3564 – 3572;,
Chiral Catalysts
Chiral catalysts – SlideShare

22795-99-9, (S)-(1-Ethylpyrrolidin-2-yl)methanamine is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a mixture of cyanuric chloride (0.368 g, 2 mmol) in CH3CN at about -20¡ã C. was added 3-fluoro-p-anisidine (0.28 g, 2 mmol) in CH3CN followed by the addition of N,N-diisopropylethylamine (DIEA) (0.35 mL, 2 mmol) and stirred for about 1 hour. The reaction mixture was then stirred at room temperature for about 1 hour. Then, cyclohexylmethyl amine (0.26 mL, 2 mmol) and DIEA (0.35 mL, 2 mmol) were added and the reaction mixture was stirred overnight at RT. Then, S-(-)-2-aminomethyl-N-ethyl pyrrolidine (0.29 mL, 2 mmol) and DIEA (0.35 mL, 2 mmol) were added and the reaction mixture was refluxed overnight. The reaction mixture was diluted with ethyl acetate and washed with brine. The organic layer was separated and dried over sodium sulfate, filtered, and concentrated under reduced. The crude material was purified by column chromatography eluding with 96:3:1 methylene chloride:methanol:conc. ammonium hydroxide to yield a white solid 141 (0.400 g, 43.7percent), mp 68-69¡ã C.; HPLC: Inertsil ODS-3V C18, 40:30:30 [KH2PO4 (0.01 M, pH 3.2):CH3OH:CH3CN], 264 nm, Rt 8.2 min, 97.1percent purity; MS (ESI): m/z 458 (M+H, 100), 362 (2.8), 230 (85.4)., 22795-99-9

22795-99-9 (S)-(1-Ethylpyrrolidin-2-yl)methanamine 643457, achiral-catalyst compound, is more and more widely used in various fields.

Reference£º
Patent; Timmer, Richard T.; Alexander, Christopher W.; Pillarisetti, Sivaram; Saxena, Uday; Yeleswarapu, Koteswar Rao; Pal, Manojit; Reddy, Jangalgar Tirupathy; Krishma Reddy, Velagala Venkata Rama Murali; Sesila Sridevi, Bhatlapenumarthy; Kumar, Potlapally Rajender; Reddy, Gaddam Om; US2004/209882; (2004); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare

(S)-(1-Ethylpyrrolidin-2-yl)methanamine, cas is 22795-99-9, it is a common heterocyclic compound, the chiral-catalyst compound, its synthesis route is as follows.,22795-99-9

Into a clean and dried 100ml two necked round-bottomed flask equipped with magnetic stirrer and nitrogen set up, Compound 11 (3.0 gm, 0.0032 mol), 40ml 1:1 mixture of ACN : water and (R)?(1-ethylpyrrolidin-2-yl)methanamine (6.26 gm, 0.048 mol) were added at RT. The reaction mixture was heated at 65¡ãC and maintained for 6 hrs. The reaction was monitored by TLC using 60 percent ethyl acetate in hexane. After completion of the reaction, the reaction mass was concentrated and quenched with 30 ml of ice cold water and the obtained precipitate was extracted with ethyl acetate (3×50 ml), combined organic layers were dried over sodium sulfate and concentrated under reduced pressure to yield 4g of crude compound 12C, which was taken as it was for next step.

As the rapid development of chemical substances, we look forward to future research findings about 22795-99-9

Reference£º
Patent; BIOPHARMATI SA; SERGIO, Lociuro; ISLAM, Khalid; (46 pag.)WO2018/67663; (2018); A2;,
Chiral Catalysts
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Benzo-18-crown 6-Ether, cas is 14098-24-9, it is a common heterocyclic compound, the chiral-catalyst compound, its synthesis route is as follows.,14098-24-9

General procedure: The carbonyl substrate (0.1 g) is dissolved in 1-2 mL of anhydrous CHCl3 and 2.0 equiv of a benzocrown ether is added to the solution. To this mixture, CF3SO3H (8.0 equiv; H2SO4 may be used in some cases) is added dropwise with stirring. The reaction is stirred at room temperature for at least 2 h, after which, the mixture is poured over several grams of ice. The resulting solution is extracted three times with CHCl3. The organic phase is subsequently washed three times with water and dried over MgSO4 solution. Removal of the solvent provides the product.

As the rapid development of chemical substances, we look forward to future research findings about 14098-24-9

Reference£º
Article; Zielinski, Matthew E.; Tracy, Adam F.; Klumpp, Douglas A.; Tetrahedron Letters; vol. 53; 14; (2012); p. 1701 – 1704;,
Chiral Catalysts
Chiral catalysts – SlideShare

63126-47-6, (S)-2-(Methoxymethyl)pyrrolidine is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,63126-47-6

EXAMPLE 10 ; 8-12-[2-(2-(S)-Methoxymethyl-pyrrolidin-1-yl)-ethyl]-benzofuran-5-yl)-6,7-dihydro-5H-1,4,8a-triaza-s-indacene: Methanesulfonic acid 2-[5-(6,7-dihydro-5H-1,4,8a-triaza-s-indacen-8-yl)-benzo-furan-2-yl]-ethyl ester (0.085 mmol) described above was dissolved in acetonitrile (2 ml) followed by addition of 2-(S)-methoxymethylpyrrolidine (0.85 mmol) and potassium carbonate (0.425 mmol) and heated to 70¡ã C. for 24 hours. The reaction was cooled, filtered and concentrated. The residue was purified via preparative HPLC to give the title compound. [M+1]+ calc’d for C25H29N4O2, 417; found, 417.

The synthetic route of 63126-47-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Athersys, Inc.; US2006/9451; (2006); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare