Day: November 3, 2020

602-09-5, [1,1′-Binaphthalene]-2,2′-diol is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of 5.73 g (20 mmol) of (1,1′-binaphthyl) -2,2′-diol and 4.10 g (20 mmol) of p-TsOH were dissolved in 150 mL of toluene,The solution was stirred at 100 & lt; 0 & gt; C for 12 hours.The reaction solution was cooled to room temperature,Adding a potassium carbonate solution thereto,The organic layer was extracted three times by using 60 mL of ethyl acetate.The organic layer thus collected was dried with magnesium sulfate,The residue obtained after the solvent was evaporated from the silica gel column chromatography was used to separate and purify the residue,To obtain 3.76 g of intermediate I-1 (yield: 70%).The compounds thus produced were determined by using liquid chromatography-mass spectrometry (LC-MS)., 602-09-5

As the paragraph descriping shows that 602-09-5 is playing an increasingly important role.

Reference£º
Patent; Sanxing Display Co., Ltd.; Shen Wenji; Li Yinyong; Jin Rongguo; Po Junhe; Li Xiaorong; Zheng Enzai; Huang Xihuan; Jin Meigeng; Liang Chengjue; (89 pag.)CN106565689; (2017); A;,
Chiral Catalysts
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As a common heterocyclic compound, it belongs to chiral-catalyst compound, name is (S)-(1-Ethylpyrrolidin-2-yl)methanamine, and cas is 22795-99-9, its synthesis route is as follows.,22795-99-9

A mixture of 2-fluoro-5-(1-trityl-1H-benzotriazol-5-yl)-benzaldehyde (368 mg, 0.76 mmol), (S)-(+)-1-ethyl-2-aminomethylpyrrolidine (120 mg, 0.83 mmol) and molecular sieves in 10 mL of methanol was stirred at ambient temperature for 3 h. The mixture was cooled to -78¡ã C., and sodium borohydride (72 mg, 1.9 mmol) was added and the mixture was allowed to warm to room temperature and stirred overnight. The volatiles were removed in vacuo and the residue was diluted with dichloromethane and washed with water. The aqueous phase extracted with dichloromethane, and the combined organic phases were washed with brine, dried over magnesium sulfate, filtered and concentrated to leave the crude product. Chromatography (elution with methanol/dichloromethane) gave 255 mg of product.

With the complex challenges of chemical substances, we look forward to future research findings about 22795-99-9,belong chiral-catalyst compound

Reference£º
Patent; AVENTIS PHARMACEUTICALS INC.; US2008/138413; (2008); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare

As a common heterocyclic compound, it belongs to chiral-catalyst compound, name is 1,3-Dimesityl-4,5-dihydro-1H-imidazol-3-ium chloride, and cas is 173035-10-4, its synthesis route is as follows.,173035-10-4

RuCl2(?CHPh)(PCy3)s (phenylmethylene-bis(tricyclohexylphosphine) ruthenium dichloride, ?catalyst (I)?) (6.00 g, 7.29 mmol, 1.0 eq.), IMesH2.HCl salt prepared above (2 eq.), and potassium t-butoxide (2 eq.) were placed in a Schlenk flask. 60 mL of anhydrous degassed hexanes (Aldrich SureSeal bottle) were added. A vacuum was applied to further degas the reaction mixture, which was then heated to 60 C. for 24 hours. The suspension changed color from purple to orange-brown over the reaction time. After approximately 24 hr, the mixture was cooled to room temperature, and an excess of 1:1 isopropanol:water (180 mL) was added. The mixture was stirred rapidly in air for 30 min., then filtered using a medium porosity frit, and washed with isopropanol-water (3¡Á100 mL) and hexanes (3¡Á100 mL). The solids were dried in in vacuo, and the yield was approximately 75%. 1H NMR (CD2Cl2, 400 MHz) delta 19.16 (s, 1H), 7.37-7.05 (m, 9H), 3.88 (s, 4H), 2.56-0.15 (m, 51H); 31P NMR (CD2Cl2, 161.9 MHz) delta 31.41; HRMS (FAB) C45H65Cl2N2PRu [M+] 848.3306, found 848.3286.

With the complex challenges of chemical substances, we look forward to future research findings about 173035-10-4,belong chiral-catalyst compound

Reference£º
Patent; CALIFORNIA INSTITUTE OF TECHNOLOGY; Grubbs, Robert H.; Chatterjee, Arnab K.; Choi, Tae-Lim; Goldberg, Steven D.; Love, Jennifer A.; Morgan, John P.; Sanders, Daniel P.; Scholl, Matthias; Toste, F. Dean; Trnka, Tina M.; (27 pag.)US9403854; (2016); B2;,
Chiral Catalysts
Chiral catalysts – SlideShare

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4488-22-6,[1,1′-Binaphthalene]-2,2′-diamine,as a common compound, the synthetic route is as follows.

General procedure: To a two-necked round-bottomed flask (50 mL) equipped with a magnetic stir bar, was added biaryldiamine 1 (or 3) (0.1 mmol) under the air. The flask was capped with a rubber septum, evacuated, and refilled with N2 gas for three times. Solvent (10 mL) and 2,6-lutidine (23.5 mg, 0.22 mmol or none) were added to the tube through the septum. To the mixture, was added t-BuOCl (23.8 mg, 0.22 mmol or 43.4 mg, 0.40 mmol) through the septum at the indicated temperature. The resulting solution was stirred for the indicated time (Table 2 in the text) before quenched with aqueous Na2S2O3 solution (1.0 M, 20 mL), and the resulting mixture was extracted with CH2Cl2 (20 mL ¡Á 3). The combined organic extracts were dried over Na2SO4 and concentrated under vacuum to give the crude product. Purification by flash column chromatography on silica gel gave the corresponding 7,8-diaza[5]helicene (for example, compound 2a: 27.2 mg, 97%).

4488-22-6, The synthetic route of 4488-22-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Takeda, Youhei; Okazaki, Masato; Maruoka, Yoshiaki; Minakata, Satoshi; Beilstein Journal of Organic Chemistry; vol. 11; (2015); p. 9 – 15;,
Chiral Catalysts
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Name is trans-Cyclohexane-1,2-diamine, as a common heterocyclic compound, it belongs to chiral-catalyst compound, and cas is 1121-22-8, its synthesis route is as follows.,1121-22-8

It was synthesized from 101.2 mg (62.3 mumol) of the [{RuCl2(dppb)}2-mu-(dppb)] [17] and 15.9 mg (129.2 mumol) of the cis and trans (+-) 1,2-diaminocyclohexane (cydn) in toluene (20 mL) under argon atmosphere. The solution was stirred for 5 h at 30 C and then the volume was reduced under vacuum to 3 mL and diethyl ether (10 mL) was added to obtain a yellow powder. The product was thoroughly washed with diethyl ether (3 * 5 mL). The yield was 96.0 mg (95%). Anal. calc. (found) for C34H42N2Cl2P2Ru: C, 61.19% (60.73); H, 6.26% (6.05); N, 3.48% (3.40); 31P{1H}-NMR (202.46 MHz, CH2Cl2/D2O): delta 45.19 (singlet, dppb), CV (TBAH, 0.1 mol L-1 CH2Cl2, 25 C, scan rate = 0.1 V s-1): Epa = 0.52 V, Epc = 0.40 V, E? = 0.46 V, |Ipa/Ipc| = 1.10. IR {KBr, 1 cm-1}: 3331, 3257 and 3054 (weak, nuN-H), 2931 and 2855 (weak,nualkyl-H), 1988, 1895, 1831, 1744 (very weak, harmonic), 1562 (medium, delta NH2def.), 1482 and 1433 (medium, nuarom.), 1093 and 1023 (strong, nuC-N), 896 and 743(strong, tau NH2), 695 and 512 (very strong, nuRu-P), 290 (medium, nu Ru-Cl). UV/vis (see Fig. 1S) (CH2Cl2, 1.27 104 mol L1), l/nm (epsilon/Lmol1cm1) 322 (4728), 456 (407).

With the complex challenges of chemical substances, we look forward to future research findings about trans-Cyclohexane-1,2-diamine

Reference£º
Article; Nascimento, Rebecca D.; Silva, Andressa K.; Liao, Luciano M.; Deflon, Victor M.; Ueno, Leonardo T.; Dinelli, Luis R.; Bogado, Andre L.; Journal of Molecular Structure; vol. 1151; (2018); p. 277 – 285;,
Chiral Catalysts
Chiral catalysts – SlideShare

As a common heterocyclic compound, it belongs to quinuclidine compound,Quinuclidine-4-carboxylic acid hydrochloride,40117-63-3,Molecular formula: C8H14ClNO462,mainly used in chemical industry, its synthesis route is as follows.,250285-32-6

Under inert atmosphere, 1,3-bis-(2,6-diisopropylphenyl)imidazolium chloride (1.59 g,3.74 mmol, 1.00 equiv.) was dissolved in dichloromethane (170 mL) and silver(I) oxide (0.478 g,2.06 mmol, 1.10 equiv.) was added. The mixture was stirred at room temperature for 25 h and then iodine (1.04 g, 4.10 mmol, 1.10 equiv.) in dichloromethane (50 mL) was added slowly andstirred overnight. The mixture was deactivated by NaS2O3, the organic layer was separated anddried over MgSO4. After removal of the solvent, the residue was dissolved in methanol and asolution of NaBPh4 (1.51 g, 4.40 mmol, 1.18 equiv.) in methanol (15 mL) was added. Theforming solid was filtrated off and dried in vacuum to afford the desired product as a colorlesssolid (2.25 g, 2.69 mmol, 72 %).

With the synthetic route has been constantly updated, we look forward to future research findings about 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride,belong chiral-catalyst compound

Reference£º
Article; Von Der Heiden, Daniel; Detmar, Eric; Kuchta, Robert; Breugst, Martin; Synlett; vol. 29; 10; (2018); p. 1307 – 1313;,
Chiral Catalysts
Chiral catalysts – SlideShare

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14098-24-9,Benzo-18-crown 6-Ether,as a common compound, the synthetic route is as follows.

A mixture of 0.27 g OfMo(CO)6 (1.03 mmol), 0.12 g of KBr (1.00 mmol) and 0.31 g of benzo-18-crown-6-ether (1.00 mmol) was refluxed in 15 ml of freshly distilled THF for 2 hours. The yellow solution was filtered and a brown oil formed and started to separate. After decanting the oil, 40 ml of hexane were added and the schlenk was left at 0 0C to isolate a yellow solid. Extraction with CH2Cl2 afforded K[benzo-18-crown-6-ether][Mo(CO)5Br] as yellow needles (75% yield , 0.5 g).Analysis Calculated for BrC21H24KMo11: C, 37.80; H, 3.62. Found: C, 37.25; H5 3.83. IR (KBr pellet), cm4: 3069 (w), 2955 (m), 2941 (m), 2921 (m), 2067 (m), 1977 (w), 1932 (sh, s), 1914 (s), 1842 (s), 1834 (s), 1638 (br, w), 1596 (w), 1523 (w), 1505 (s), 1478 (w), 1457 (m), 1436 (w), 1382 (w), 1355 (m), 1343 (m), 1325 (m), 1286 (m), 1247 (s), 1214 (s), 1178 (br, sh5 w), 1166 (w), 1126 (m), 1116 (m), 1108 (m), 1097 (sh, w), 1083 (w), 1075 (w), 1055 (w), 961 (m), 952 (m), 935 (w), 922 (w), 908 (w), 882 (w), 860 (w), 848 (w), 833 (w), 806 (br, w), 782 (m), 737 (s), 598 (s), 542 (m), 507 (w), 463 (w). 1H NMR (CD2Cl2, 300 MHz): 7.00-6.90 (c, 4H, C6H4 crown ether), 4.22 + 3.95 + 3.77-3.42 (c, 1OH, aliphatic crown ether protons)., 14098-24-9

As the paragraph descriping shows that 14098-24-9 is playing an increasingly important role.

Reference£º
Patent; ALFAMA – INVESTIGACAO E DESENVOLVIMENTO DE PRODUTOS FARMACEUTICOS LDA.; WO2007/73225; (2007); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1121-22-8,trans-Cyclohexane-1,2-diamine,as a common compound, the synthetic route is as follows.

General procedure: A solution of phenyl salicylate (2.13 g, 9.9 mmol) in 2-propanol (30 mL) was added to a 2-propanol solution (10 mL) containing 1,2-diamino-2-methylpropane (0.93 g, 10.6 mmol) dropwise with stirring. The mixture was stirred overnight at room temperature. The resulting white precipitate was collected by filtration, washed with 2-propanol and diethyl ether, and dried in vacuo., 1121-22-8

1121-22-8 trans-Cyclohexane-1,2-diamine 43806, achiral-catalyst compound, is more and more widely used in various fields.

Reference£º
Article; Mitsuhashi, Ryoji; Suzuki, Takayoshi; Sunatsuki, Yukinari; Kojima, Masaaki; Inorganica Chimica Acta; vol. 399; (2013); p. 131 – 137;,
Chiral Catalysts
Chiral catalysts – SlideShare

Name is (S)-Azetidine-2-carboxylic acid, as a common heterocyclic compound, it belongs to chiral-catalyst compound, and cas is 2133-34-8, its synthesis route is as follows.,2133-34-8

EXAMPLE 3 Methanol (40mL) was added to the (R)-4-phthalimido-2-chlorobutyric acid (5 g) and the mixture was stirred. To the mixture 80% hydrazine hydrate (2.3 g) was added with stirring, and the mixture was stirred at 40C overnight. Water (30 mL) was then added to the mixture with stirring, and 47% sulfuric acid (13 mL) was added. The mixture was stirred at room temperature for 4 hours and the precipitate was filtered out. The filtrate was concentrated under reduced pressure to recover an aqueous solution of (R)-4-amino-2-chlorobutyric acid. A small amount of the solution was sampled to identify the molecular structure by NMR. The analytical data was as follows:1H-NMR (D2O): delta 2.15-2.45 (m,2H), 3.19 (t,2H), 4.45 (t, 1H) The solution was then placed in an ice bath and an aqueous sodium hydroxide solution (400 g/L) was added to the solution in order to adjust the pH of the solution to 2.0. Water was added to the solution to obtain about 130 g of solution. The resultant solution was heated to about 90C with stirring. Magnesium hydroxide (1.0 g) was added to the solution and the solution was stirred for 5 hours to produce an aqueous solution of (S)-azetidine-2-carboxylic acid. A small amount of the solution was sampled to identify the molecular structure by NMR. The analytical data was as follows: 1H-NMR (CD3OD): delta 2.15 (m,1H), 2.58 (m,1H), 3.90 (m,1H), 4.02 (q,1H), 4.60 (t,1H) The solution was spontaneously cooled to room temperature. Sodium carbonate (2.1 g) and DIBOC (4.3 g) were added with stirring and the mixture was further stirred overnight. Hydrochloric acid (6N) was added to the solution in order to adjust the pH of the solution to 2.0. The resultant solution was extracted with ethyl acetate three times. The resultant organic solution was washed with a saturated brine solution and dried with sodium sulfate. The solvent in the mixture was then removed to recover (S)-N-(tert-butoxycarbonyl)azetidine-2-carboxylic acid (2.1 g) (yield 55%, optical purity 89.3 %e.e.). A small amount of the solution was sampled to identify the molecular structure by NMR. The analytical data was as follows:1H-NMR (CDCl3): delta 1.48 (s,9H), 2.40-2.60 (bs,2H), 3.80-4.00 (bs,2H), 4.80 (t,1H)

With the complex challenges of chemical substances, we look forward to future research findings about (S)-Azetidine-2-carboxylic acid

Reference£º
Patent; KANEKA CORPORATION; EP1415985; (2004); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1121-22-8,trans-Cyclohexane-1,2-diamine,as a common compound, the synthetic route is as follows.

General procedure: Aldehyde (2.2 mmol, salicylaldehyde or 4-methoxysalicylaldehyde, 4-diethylamino-2-hydroxy benzaldehyde or 2,4-dihydroxybenzaldehyde) was dissolved in ethanol (30 ml) and stirred at room temperature. To this solution, either ethylene diamine (1 mmol) or trans-1,2-diaminocyclohexane (1 mmol) was added drop-wise under stirring. The immediate appearance of yellow colour indicates the formation of Schiff bases. The solution was allowed to stir for another 6 h at room temperature that produced yellow to light yellow coloured precipitates. The formed precipitate was filtered off, washed with ethanol and dried under vacuum.

1121-22-8, 1121-22-8 trans-Cyclohexane-1,2-diamine 43806, achiral-catalyst compound, is more and more widely used in various fields.

Reference£º
Article; Hariharan; Anthony, Savarimuthu Philip; Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy; vol. 136; PC; (2015); p. 1658 – 1665;,
Chiral Catalysts
Chiral catalysts – SlideShare