21436-03-3, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn¡¯t involve a screen. 21436-03-3, C6H14N2. A document type is Chapter, introducing its new discovery.
Palladium- and copper-catalysed C-N cross-coupling in drug discovery
The impact of palladium- and copper-catalysed C-N cross-coupling reactions in the pharmaceutical industry is immense. These methodologies are routinely applied to the expedient synthesis of complex (hetero)arylamines utilizing a breadth of amine feedstocks including basic alkylamines and weakly nucleophilic N-H azoles. The focus of this chapter is to illustrate the power and complementarity of palladium and copper C-N cross-coupling reactions. To this end, we will discuss recent literature examples showcasing both the development of structure-activity relationship studies in early drug discovery and the optimization of late-stage process development of clinical candidates. In addition, recent advances of challenging C-N cross-coupling reactions will be highlighted within the context of future applications to support drug discovery and development.
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Reference£º
Chiral Catalysts,
Chiral catalysts – SlideShare