In an article, published in an article, once mentioned the application of 21436-03-3, Name is (1S,2S)-Cyclohexane-1,2-diamine,molecular formula is C6H14N2, is a conventional compound. this article was the specific content is as follows.Application In Synthesis of (1S,2S)-Cyclohexane-1,2-diamine
An aldehyde that is not fluorescent responsive toward a chiral diamine has been converted to a sensitive fluorescence enhancement sensor through incorporation of an additional hydrogen bonding unit to increase the structural rigidity of the reaction product of the aldehyde with the diamine. This new chiral aldehyde is synthesized in one step from the reaction of (S)-3-formylBINOL with salicyl chloride. When treated with trans-1,2-cyclohexanediamine in ethanol, it shows greatly enhanced fluorescence at lambda=410 nm with good enantioselectivity. NMR and mass spectroscopic methods are used to investigate the reaction of the chiral aldehyde with the diamine. This study has revealed a two-stage reaction mechanism including a fast imine formation and a slow ester cleavage. An aldehyde that is not fluorescent responsive toward a chiral diamine has been converted to a sensitive fluorescence enhancement sensor through incorporation of an additional hydrogen bonding unit, which increases the structural rigidity of the reaction product with the diamine and gives a large fluorescence enhancement. Highly enantioselective fluorescence recognition of 1,2-diaminocyclohexane with the new BINOL-based aldehyde has been achieved.
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Reference：
Chiral Catalysts,
Chiral catalysts – SlideShare