Electric Literature of 21436-03-3, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn’t involve a screen. 21436-03-3, C6H14N2. A document type is Article, introducing its new discovery.
Herein a new 11C radiolabelling strategy for the fast and efficient synthesis of thioureas and related derivatives using the novel synthon, 11CS2, is reported. This approach has enabled the facile labelling of a potent progesterone receptor (PR) agonist, [11C]Tanaproget, by the intramolecular reaction of the acyclic aminohydroxyl precursor with 11CS2, which has potential applications as a positron emission tomography radioligand for cancer imaging. Time is on my side: A wide range of 11C (t1/2=20.4 min) molecules can now be accessed by reaction with the novel synthon, 11CS2, within short reaction times. This includes access to an exact 11C equivalent of the potent progesterone receptor agonist, Tanaproget, that has potential applications for positron emission tomography cancer imaging.
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