Reference of 21436-03-3, Chemistry can be defined as the study of matter and the changes it undergoes. You’ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology.21436-03-3, Name is (1S,2S)-Cyclohexane-1,2-diamine, molecular formula is C6H14N2. In a patent, introducing its new discovery.
QSAR’s by the MTD-method for a series of 32 derivatives of cAMP with large substituents in position 8 and for a series of 21 derivatives with large substituents in position 2 are obtained. Thiophosphoric acid derivatives are also included. As structural parameters, the relative nitrogen base lipophilicity, the presence of an equatorial or axial S atom and the presence of aliphatic amino group, protonated at pH = 7 are considered. Satisfactory correlational results, including a cross-validation like procedure, are obtained in most cases. The results emphasize structural features important for binding to four sites (AI, BI, AII and BII) of two different protein phosphokinases (cAKI and cAKII). The synthesis and characterization of eight new compounds are also described.
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