Safety of H-Leu-NH2.HCl. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: H-Leu-NH2.HCl, is researched, Molecular C6H15ClN2O, CAS is 10466-61-2, about Peptide synthesis catalyzed by α-chymotrypsin immobilized in the poly(N-isopropylacrylamide/acrylamide) gel.
The peptide syntheses were performed with α-chymotrypsin immobilized in the thermosensitive poly(N-isopropylacrylamide/acrylamide) (NIPAAm/AAm) gels. In the reaction between Ac-Phe-OEt and H-Ala-NH2, the product ratio of Ac-Phe-Ala-NH2/Ac-Phe-OH increased with lowering temperature The highest ratio was 3.3 in the reaction with the immobilized enzyme at -10°, whereas it was around 1.4 with the free enzyme at 34°. On the contrary, Cbz-Phe-Leu-NH2 obtained from Cbz-Phe-OH and H-Leu-NH2 increased with increasing temperature (conversion: 13% at 10° and 34% at 35°) in Tris buffer without the organic solvent. The gel of NIPAAm copolymerized with AAm (NIPAAm/AAm = 80/20) was effective as compared with the poly(NIPAAm) gel for α-chymotrypsin-catalyzed peptide synthesis using the ester substrate as the acyl donor. The reaction mechanism was discussed in connection with the hydrophobic surroundings inside the deswollen thermosensitive polymer gel.
There is still a lot of research devoted to this compound(SMILES：N[C@@H](CC(C)C)C(N)=O.[H]Cl)Safety of H-Leu-NH2.HCl, and with the development of science, more effects of this compound(10466-61-2) can be discovered.