With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.673-06-3,D-Phenylalanine,as a common compound, the synthetic route is as follows.
673-06-3, In 50ml dried single necked flask, 0.5g(R) -2-amino-3-phenylpropanoic acid dissolved in 4ml THF and 1ml of water, At RT., add 0.127g (1.05eq) of sodium hydroxide to make alkaline, stirred for 30min,cooled to about 0 deg.C. Slowly dropped 0.727g (1.1eq) (Boc)2O in THF solution. Naturally warm to RT and react for 3h. The reaction was stopped, the low temperature regulator 3 to PH = 4 and extracted 5 times with EA and extracted,washed with water and saturated brine, dried and concentrated to give a light brown oil 412mg.
673-06-3 D-Phenylalanine 71567, achiral-catalyst compound, is more and more widely used in various fields.
Reference£º
Patent; Shandong Kaisen Pharmaceutical Co., Ltd.; Wu, Junjun; Li, Rui; Jiang, Xiangsheng; Song, Jiaqi; Yang, Shuangbing; Zhang, Jingyu; Zhang, Erli; (37 pag.)CN105294669; (2016); A;,
Chiral Catalysts
Chiral catalysts – SlideShare