Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: H-Leu-NH2.HCl, is researched, Molecular C6H15ClN2O, CAS is 10466-61-2, about Organic reactions catalyzed by insolubilized enzymes. I. Peptide synthesis catalyzed by insolubilized α-chymotrypsin.Category: chiral-catalyst.
The synthesis of several peptide bonds (Tyr-Leu, Tyr-Gly and Tyr-Ala) was carried out in organic-aqueous media under kinetically controlled conditions. Insolubilized α-chymotrypsin on agarose was used as catalyst. A 60%-70% yield in peptide was obtained using 20% DMF, pH = 10 and temperature 25°. The influence of several organic solvents in the catalytic activity of the enzyme was analyzed. The influence of the pH was studied; pH >8 favors the synthesis of peptide. The nature of the nucleophile (L-Leu, GLy or L-Ala) does not seem to any great extent to affect the yield in peptide at constant reaction time. From these data a more detailed mechanism of the enzymic activity is proposed.
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