A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 1436-59-5, Name is cis-Cyclohexane-1,2-diamine, molecular formula is C6H14N2. In a Article£¬once mentioned of 1436-59-5, Quality Control of: cis-Cyclohexane-1,2-diamine
Synthesis and evaluation of series of diazine-bridged dinuclear platinum(II) complexes through in vitro toxicity and molecular modeling: Correlation between structure and activity of pt(II) complexes
Polynuclear Pt(II) complexes are a novel class of promising anticancer agents with potential clinical significance. A series of pyrazine (pz) bridged dinuclear Pt(II) complexes with general formulas {[Pt(L)Cl]2(mu-pz)}2+ (L, ethylenediamine, en; (¡À)-1,2-propylenediamine, 1,2-pn; isobutylenediamine, ibn; trans-(¡À)-1,2-diaminocyclohexane, dach; 1,3-propylenediamine, 1,3-pd; 2,2-dimethyl-1,3-propylenediamine, 2,2-diMe-1,3-pd) and one pyridazine (pydz) bridged {[Pt(en)Cl]2(mu-pydz)}2+ complex were prepared. The anticancer potential of these complexes were determined through in vitro cytotoxicity assay in human fibroblasts (MRC5) and two carcinoma cell lines (A375 and HCT116), interaction with double stranded DNA through in vitro assay, and molecular docking study. All complexes inhibited cell proliferation with inhibitory concentrations in the 0.5-120 muM range. While {[Pt(1,3-pd)Cl]2(mu-pz)}2+ showed improved activity and {[Pt(en)Cl]2(mu-pydz)}2+ showed comparable activity to that of clinically relevant cisplatin, {[Pt(en)Cl]2(mu-pydz)}2+ was less toxic in an assay with zebrafish (Danio rerio) embryos, causing no adverse developmental effects. The in vitro cytotoxicity of all diazine-bridged dinuclear Pt(II) complexes is discussed in correlation to their structural characteristics.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Quality Control of: cis-Cyclohexane-1,2-diamine. In my other articles, you can also check out more blogs about 1436-59-5
Reference£º
Chiral Catalysts,
Chiral catalysts – SlideShare