In an article, published in an article, once mentioned the application of 1806-29-7, Name is 2,2-Biphenol,molecular formula is C12H10O2, is a conventional compound. this article was the specific content is as follows.Computed Properties of C12H10O2
Epigenetic toxicity of hydroxylated biphenyls and hydroxylated polychlorinated biphenyls on normal rat liver epithelial cells
2-Biphenylol, 3-biphenylol, 2,2?-biphenyldiol, 3,3?-biphenyldiol, 3-chloro-2-biphenylol, and 4,4?-dichloro-3-biphenylol were evaluated using the scrape-loading/dye transfer (SL/ DT) technique to determine in vitro gap junctional intercellular communication (GJIC) in a normal rat liver epithelial cell line as a measure of the epigenetic toxicity. Cytotoxicity was determined using the neutral red uptake assay. A dose range of 0-300 muM was examined. Only 3,3?-biphenyldiol and 4,4?-dichloro-3-biphenylol induced cytotoxicity within the tested dose ranges. Noncytotoxic doses were selected for evaluation of epigenetic toxicity. 4,4?-Dichloro-3-biphenylol was most inhibitory to GJIC at the lowest dose. The cytotoxicity and GJIC inhibitory effects observed for 4,4?-dichloro-3-biphenylol might be, although not exclusively, a consequence of the lipophilic nature of this chemical. 3-Chloro-2-biphenylol was least inhibitory to GJIC. 3-Chloro-2-biphenylol was less inhibitory to GJIC than 2-biphenylol because of the presence of the chlorine functional group, which appears to attenuate the toxic effect of the ortho-hydroxyl group. Although cells were capable of complete recovery of GJIC after removal of each of the chemicals, only with 2,2?-biphenyldiol and 4,4,?-dichloro-3-biphenylol did the cells demonstrate partial recovery without removal of the chemical. The more noncoplanar conformation of 2,2?-biphenyldiol and 2-biphenylol might explain their more inhibitory behavior in comparison to 3,3?-biphenyldiol and 3-biphenylol, respectively.
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Chiral Catalysts,
Chiral catalysts – SlideShare