673-06-3, D-Phenylalanine is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
EXAMPLE I Preparation of R-2-bromo-3-phenylpropionic acid 46.0 ml of water was introduced into a 1-litre double-walled glass reactor connected to a cooling medium. 275.5 g of 48% HBr was added. The jacket cooling and stirring were started. Subsequently, 67.7 g of 45% KOH was slowly added. The reaction mixture was cooled to 30-40 C. 45.0 g of D-phenylalanine was added to the reaction mixture. Next, 213 ml of toluene was added to the reaction mixture. The reaction mixture was cooled to 3 C. In 6 hours 95.9 g of NaNO2, a 30% solution in water, was added to the reaction mixture. The temperature was kept at 5 C. After the reaction stirring was continued for 3 hours at 3 C. The reaction mixture was heated to 20 C. Stirring was stopped and the aqueous phase was separated off. Then the toluene phase was extracted twice with 95 ml of water. The reaction mixture was heated to 70 C. and a 100 mbar vacuum was created using a vacuum pump. The water was removed by distillation using a Dean Stark apparatus until the toluene phase was free of water. Yield: 84.0% R-2-bromo-3-phenylpropionic acid in the toluene solution, relative to D-phenylalanine., 673-06-3
673-06-3 D-Phenylalanine 71567, achiral-catalyst compound, is more and more widely used in various fields.
Reference£º
Patent; Lommen, Franciscus Alphons Marie; Koller, Helmut; Scherubl, Herbert; US2003/125575; (2003); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare