Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, the author is Dalko, Peter I. and a compound is mentioned, 21436-03-3, (1S,2S)-Cyclohexane-1,2-diamine, introducing its new discovery. 21436-03-3
A concise synthesis of (-)-mesembrine
(-)-Mesembrine 11 was synthesized in 7 steps, in 19.4% overall yield and with ee>95%. The key step of the sequence is a stereoselective alkylation reaction of dianion derived from C2 symmetric imidazolines allowing efficient formation of quaternary benzylic center. Chiral auxiliaries derived from (S,S)-1,2-diamino-1,2-diphenylethane 1a and (S,S)-1,2-diaminocyclohexane 1b were compared. This synthesis provided unambiguous correlation of the newly formed stereocenter.
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Reference£º
Chiral Catalysts,
Chiral catalysts – SlideShare