Category: 10466-61-2

Recommanded Product: H-Leu-NH2.HCl. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: H-Leu-NH2.HCl, is researched, Molecular C6H15ClN2O, CAS is 10466-61-2, about Prediction of chiral separation of ketoprofen using experimental design. Author is Valliappan, K.; Kannan, K.; Manavalan, R.; Muralidharan, C..

The paper demonstrates how exptl. design could be applied to predict chiral resolution and run time for indirect chiral HPLC anal. of ketoprofen. An attempt is made to establish quant. relation between chromatog. variables and the response factors (resolution and retention time). The effects of important chromatog. variables on chiral resolution and retention time were highlighted by way of interaction studies. This technique enables optimal use of resources by avoiding trial and error approach. The study advocates that exptl. design is a prospective tool to predict and optimize chromatog. conditions for chiral HPLC anal.

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Chiral Catalysts,
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Application In Synthesis of H-Leu-NH2.HCl. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: H-Leu-NH2.HCl, is researched, Molecular C6H15ClN2O, CAS is 10466-61-2, about Semisynthesis of human growth hormone-releasing factor by trypsin catalyzed coupling of leucine amide to a C-terminal acid precursor. Author is Bongers, Jacob; Offord, Robin E.; Felix, Arthur M.; Campbell, Robert M.; Heimer, Edgar P..

Human growth hormone-releasing factor, GRF(1-44)-NH2, was synthesized by trypsin catalyzed coupling of Leu-NH2 to Arg43 of the precursor, GRF(1-43)-OH, prepared by solid phase peptide synthesis. The semisynthetic GRF(1-44)-NH2 was fully characterized and showed full potency in the rat pituitary in vitro bioassay. Conversion to GRF(1-44)-NH2 was limited to 60-70% in both 75% v:v N,N-dimethylacetamide and 95% v:v 1,4-butanediol, due to competing transpeptidations at Arg41 and Arg38 generating [Leu42]-GRF(1-42)-NH2 and [Leu39]-GRF(1-39)-NH2 side products, resp. The rates of formation and yields of GRF(1-44)-NH2 vs. pH, Leu-NH2 concentration, and solvent composition were also studied.

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Reference:
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Synthetic Route of C6H15ClN2O. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: H-Leu-NH2.HCl, is researched, Molecular C6H15ClN2O, CAS is 10466-61-2, about Peptide synthesis with modified trypsin.

The authors have studied the relative abilities of native trypsin and its ethylene glycol bis(succinimidyl succinate)-modified derivative (EG-trypsin) as catalysts in the kinetically controlled synthesis of short peptides in acetonitrile-based and aqueous (borate) media. For example, PhCO-Arg-Leu-NH2 was synthesized from PhCO-Arg-OEt·HCl and H-Leu-NH2·HCl using both native and EG-trypsin in 95% acetonitrile at 4° C. The yield for the dipeptide was 94% with EG-trypsin after 6 h of reaction time, whereas the same yield was obtained after 24 h of reaction time with the native trypsin. EG-trypsin enabled maximum product yield more rapidly than native trypsin in the acetonitrile media; opposite was true in borate buffer.

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Reference:
Chiral Catalysts,
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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Synthesis and application of new chiral variants of Marfey’s reagent for liquid chromatographic separation of the enantiomers of α-amino acids, published in 2008-09-30, which mentions a compound: 10466-61-2, Name is H-Leu-NH2.HCl, Molecular C6H15ClN2O, Electric Literature of C6H15ClN2O.

Two new structural variants of Marfey’s reagent (1-fluoro-2,4-dinitrophenyl-5-L-alaninamide, FDNP-L-Ala-NH2) were synthesized by nucleophilic substitution of one fluorine atom in 1,5-difluoro-2,4-dinitrobenzene (DFDNB) by L-methioninamide or D-phenylglycinamide. The new variants FDNP-L-Met-NH2 and FDNP-D-Phg-NH2 were characterized and used for derivatization of twenty-six α-amino acids. The resulting diastereomeric derivatives were separated on a reversed-phase C18 HPLC column using a linear gradient of acetonitrile and aqueous trifluoroacetic acid (TFA) and the results were compared with those obtained using Marfey’s reagent. To determine and establish the efficiency of both the new variants, separation results were compared for disastereomers of five representative amino acids (Ala, Phe, Ser, Asp, and Asn) prepared with MR, FDNP-L-Phe-NH2, FDNP-L-Leu-NH2, FNDP-L-Leu-NH2, and FDNP-L-Pro-NH2, experiments being performed under identical conditions. Both the new chiral reagents enabled better separation of the diastereomers than Marfey’s reagent for most of the amino acids. The reagent FDNP-D-Phg-NH2 enabled excellent separation for serine and asparagine whereas other reagents failed or provided poor results.

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Chiral Catalysts,
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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Comparison of enzymic semisyntheses of peptide amides: human growth hormone releasing factor and analogs, published in 1991, which mentions a compound: 10466-61-2, Name is H-Leu-NH2.HCl, Molecular C6H15ClN2O, Reference of H-Leu-NH2.HCl.

Enzymic semisyntheses of growth hormone releasing factor (GRF), a 44-residue peptide amide hormone, from C-terminal acid precursors are compared. A recombinant α-amidating enzyme was used to convert the glycine-extended precursor, GRF(1-44)-Gly-OH, to GRF(1-44)-NH2 in an essentially quant. fashion). Trypsin was used to convert the precursors, GRF(1-43)-OH and GRF(1-44)-OH, to GRF(1-44)-NH2 (60 and 15% conversion, resp.) in a 75% (v:v) aqueous AcNMe2 containing a large excess of leucine amide. Carboxypeptidase Y-catalyzed transpeptidations of the precursors GRF(1-44)-OH and [Ala44]-GRF(1-44)-OH to GRF(1-44)-NH2 in aqueous leucine amide solutions were also attempted. The trypsin-catalyzed direct amidation of [Ala15]-GRF(1-29)-OH in concentrated ammonium acetate/ammonia buffer (95%, 1,4-butanediol cosolvent) to form the superactive analog [Ala15]-GRF(1-29)-NH2 (ca. 25% conversion at equilibrium) is also described.

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Chiral Catalysts,
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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 10466-61-2, is researched, Molecular C6H15ClN2O, about Metabolic regulation by leucine of translation initiation through the mTOR-signaling pathway by pancreatic β-cells, the main research direction is leucine translation initiation mTOR signaling pancreas beta cell.Name: H-Leu-NH2.HCl.

Recent findings have demonstrated that the branched-chain amino acid leucine can activate the translational regulators, phosphorylated heat- and acid-stable protein regulated by insulin (PHAS-I) and p70 S6 kinase (p70s6k), in an insulin-independent and rapamycin-sensitive manner through mammalian target of rapamycin (mTOR), although the mechanism for this activation is undefined. It has been previously established that leucine-induced insulin secretion by β-cells involves increased mitochondrial metabolism by oxidative decarboxylation and allosteric activation of glutamate dehydrogenase (GDH). The authors now show that these same intramitochondrial events that generate signals for leucine-induced insulin exocytosis are required to activate the mTOR mitogenic signaling pathway by β-cells. Thus, a minimal model consisting of leucine and glutamine as substrates for oxidative decarboxylation and an activator of GDH, resp., confirmed the requirement for these two metabolic components and mimicked closely the synergistic interactions achieved by a complete complement of amino acids to activate p70s6k in a rapamycin-sensitive manner. Studies using various leucine analogs also confirmed the close association of mitochondrial metabolism and the ability of leucine analogs to activate p70s6k. Furthermore, selective inhibitors of mitochondrial function blocked this activation in a reversible manner, which was not associated with a global reduction in ATP levels. These findings indicate that leucine at physiol. concentrations stimulates p70s6k phosphorylation via the mTOR pathway, in part, by serving both as a mitochondrial fuel and an allosteric activator of GDH. Leucine-mediated activation of protein translation through mTOR may contribute to enhanced β-cell function by stimulating growth-related protein synthesis and proliferation associated with the maintenance of β-cell mass.

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Chiral Catalysts,
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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: H-Leu-NH2.HCl, is researched, Molecular C6H15ClN2O, CAS is 10466-61-2, about Organic reactions catalyzed by insolubilized enzymes. I. Peptide synthesis catalyzed by insolubilized α-chymotrypsin.Category: chiral-catalyst.

The synthesis of several peptide bonds (Tyr-Leu, Tyr-Gly and Tyr-Ala) was carried out in organic-aqueous media under kinetically controlled conditions. Insolubilized α-chymotrypsin on agarose was used as catalyst. A 60%-70% yield in peptide was obtained using 20% DMF, pH = 10 and temperature 25°. The influence of several organic solvents in the catalytic activity of the enzyme was analyzed. The influence of the pH was studied; pH >8 favors the synthesis of peptide. The nature of the nucleophile (L-Leu, GLy or L-Ala) does not seem to any great extent to affect the yield in peptide at constant reaction time. From these data a more detailed mechanism of the enzymic activity is proposed.

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Application of 10466-61-2. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: H-Leu-NH2.HCl, is researched, Molecular C6H15ClN2O, CAS is 10466-61-2, about Total synthesis of the post-translationally modified polyazole peptide antibiotic Goadsporin. Author is Dexter, Hannah L.; Williams, Huw E. L.; Lewis, William; Moody, Christopher J..

The structurally unique polyazole antibiotic goadsporin contains six heteroaromatic oxazole and thiazole rings integrated into a linear array of amino acids that also contains two dehydroalanine residues. An efficient total synthesis of goadsporin is reported in which the key steps are the use of rhodium(II)-catalyzed reactions of diazocarbonyl compounds to generate the four oxazole rings, which demonstrates the power of rhodium carbene chem. in organic chem. synthesis.

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, U.S. Gov’t, P.H.S., Journal of Medicinal Chemistry called Stereochemical studies on medicinal agents. 30. Investigation of 4-(3-hydroxyphenyl)-4-methylpipecolic acid as a conformationally restricted mimic of the tyrosyl residue of leucine-enkephalinamide, Author is Sugg, Elizabeth E.; Portoghese, Philip S., which mentions a compound: 10466-61-2, SMILESS is N[C@@H](CC(C)C)C(N)=O.[H]Cl, Molecular C6H15ClN2O, Recommanded Product: H-Leu-NH2.HCl.

The cis and trans forms of enkephalin analog I (R = H) (II) were prepared by coupling the resp. cis and trans forms of pipecolic acid III with H-Gly-Gly-Phe-Leu-NH2 by DCC/HOBt and debenzylating the resulting I (R = CH2Ph) by hydrogenolysis. N-Benzyl-4-piperidinone was treated with m-bromoanisole in the presence of BuLi to give piperidinol IV, which was dehydrated by p-MeC6H4SO3H in refluxing toluene to give tetrahydropyridine V. V was methylated by (MeO)2SO/BuLi to give 4-Me derivative VI, which was treated with HClO4/KCN to give cyanopiperidine VI, which was hydrolyzed by concentrated HCl to give cis- and trans-II. Despite spatial analogy between trans-II and leucine-enkephalinamide, trans-II possessed neither opioid agonist nor antagonist activity.

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Khmel’nitskii, Yu. L.; Martinek, K. published the article 《Enzymatic synthesis in biphasic water-organic systems. V. Optimization of preparative synthesis of a peptide》. Keywords: optimization peptide synthesis chymotrypsin catalyst; enzyme peptide synthesis biphasic system.They researched the compound: H-Leu-NH2.HCl( cas:10466-61-2 ).COA of Formula: C6H15ClN2O. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:10466-61-2) here.

α-Chymotrypsin-catalyzed coupling of Ac-Trp-OH with H-Leu-NH2-HCl in EtOAc-H2O were optimized. The product, Ac-Trp-Leu-NH2, was obtained in ∼100% yield under the following conditions: EtOAc/H2O volume ratio 50, aqueous phase pH 6-9, and initial reactant concentrations 3 × 10-9 M.

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