Category: 10466-61-2

Reference of H-Leu-NH2.HCl. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: H-Leu-NH2.HCl, is researched, Molecular C6H15ClN2O, CAS is 10466-61-2, about Total synthesis of the cyclopeptide alkaloid abyssenine A. Application of inter- and intramolecular copper-mediated coupling reactions in organic synthesis. Author is Toumi, Mathieu; Couty, Francois; Evano, Gwilherm.

The total synthesis of the 15-membered ring cyclopeptide alkaloid abyssenine A (I) has been achieved with a longest linear sequence of 15 steps. Central to the synthetic approach was an efficient copper-mediated Ullmann coupling/Claisen rearrangement sequence allowing for both ipso and ortho functionalization of aromatic iodide. This sequence was used for the synthesis of the aromatic core. The synthetic utility of copper-catalyzed coupling reactions was further demonstrated to install the enamide with a concomitant straightforward macrocyclization starting from acyclic α-amido-ω-vinyl iodide.

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Stasinska, B.; Danielsson, B.; Mosbach, K. published the article 《The use of biosensors in bioorganic synthesis: peptide synthesis by immobilized α-chymotrypsin assessed with an enzyme thermistor》. Keywords: peptide preparation immobilized chymotrypsin biosensor.They researched the compound: H-Leu-NH2.HCl( cas:10466-61-2 ).Name: H-Leu-NH2.HCl. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:10466-61-2) here.

Biosensor anal. of peptide synthesis in organic solvents using immobilized α-chymotrypsin is described. It is shown that with the enzyme thermistor used, a direct correlation exists between the neg. ΔT values registered and the amount of peptides formed (essentially various N-acetyldipeptide amides) allowing concentrations of 0.1 mM peptide and lower to be determined directly in the reaction medium.

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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 10466-61-2, is researched, Molecular C6H15ClN2O, about Synthesis of 2-methoxy-3-isobutyl pyrazine-(methoxy-13C), the main research direction is isotope labeling methoxy isobutyl pyrazine.Application of 10466-61-2.

In recent years, stable isotope tracer technique plays an important role in metabonomics research. This work was designed through using leucine amide hydrochloride as raw material to perform cyclization reaction with glyoxal to obtain the intermediate 2-hydroxy-3-iso-Bu pyrazine, then preparing 2-chloro-3-iso-Bu pyrazine by chlorination reaction, and preparing 2-methoxy-3-iso-Bu pyrazine-(methoxy-13C) under alk. conditions by condensation reaction with isotope labeling of methanol-13C. The synthetic route could avoid the intermediate from changing from enol to keto and obtain the isomer of the target product. It had the advantages of simple operation, short process flow and less side products. The yield of target compound was more than 70%, and 13C labeled isotope abundance was not diluted The product was confirmed by HPLC, MS, 1HNMR and 13CNMR. The chem. purity was more than 99%, and the deuterium enrichment was more than 98.8 atom% 13C.

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 10466-61-2, is researched, SMILESS is N[C@@H](CC(C)C)C(N)=O.[H]Cl, Molecular C6H15ClN2OJournal, Article, Research Support, Non-U.S. Gov’t, International Journal of Peptide & Protein Research called Protease-catalyzed synthesis of Leu-enkephalin in a solvent-free system, Author is Klein, Jens Uwe; Cerovsky, Vaclav, the main research direction is enzymic peptide coupling leucine enkephalin; protease catalyst peptide coupling leucine enkephalin.Application of 10466-61-2.

The total enzymic synthesis of a model peptide Leu-enkephalin on a preparative scale was accomplished in the so-called solvent-free system. The syntheses were carried out in a rotary glass homogenizer by admixing solid reactants with native proteases and Na2CO3·10H2O. The most feasible way leading to biol. active Leu-enkephalin, was based on the strategy of 2 + (1 + 2) condensation catalyzed by α-chymotrypsin, thermolysin and papain for the final segment coupling. Subtilisin was used for the ester hydrolysis of peptide intermediates. Alternative strategies as well as the influence of several reaction conditions on the yield of the protease-catalyzed synthesis of Leu-enkephalin or Leu-enkephalin amide were also investigated.

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Related Products of 10466-61-2. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: H-Leu-NH2.HCl, is researched, Molecular C6H15ClN2O, CAS is 10466-61-2, about Behavior of 3-Isobutyl-2-hydroxypyrazine (IBHP), a Key Intermediate in 3-Isobutyl-2-methoxypyrazine (IBMP) Metabolism, in Ripening Wine Grapes.

3-Isobutyl-2-hydroxypyrazine (IBHP) is thought to be a key intermediate in both the biosynthesis and degradation of the herbaceous-smelling 3-isobutyl-2-methoxypyrazine (IBMP), but its behavior during the growing season is not well understood. First, an improved method for IBHP quantification was developed. A deuterated IBHP standard was added to samples prior to isolation by mixed-mode cation exchange solid phase extraction Extracts were silylated prior to quantification by GC-MS. A limit of detection of ca. 20 ng/L could be achieved for a 100 mL juice sample. This method was used to quantify IBHP during the 2010 growing season in berries of two clones of Cabernet franc in the Finger Lakes region of New York and of Merlot grown in the California Central Valley. For all three sources, IBHP was detectable at the earliest sampling point, and its concentration per berry increased to a maximum around veraison, 208-477 pg/berry. On a per berry basis, IBHP peaked and began to decline 1-2 wk after IBMP, indicating that previous studies that sampled preveraison fruit have missed the true maximum value of IBHP. The highest per berry concentration of IBHP observed was in the California Merlot. However, after veraison, IBHP declined more rapidly in the California Merlot than in the New York Cabernet franc, such that the Merlot had the lowest IBHP concentration at harvest. Thus, IBHP at harvest cannot be used as a proxy for IBMP at veraison as was previously suggested.

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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: H-Leu-NH2.HCl, is researched, Molecular C6H15ClN2O, CAS is 10466-61-2, about Molecular-Iodine-Mediated, Efficient One-Pot Synthesis of 2-Iminohydantoins and 2-Amino-1H-imidazol-4(5H)-ones by Cyclodeselenization of Selenourea-Tethered Amides/Peptides.Reference of H-Leu-NH2.HCl.

An efficient one-pot synthesis of 2-iminohydantoins e.g., I and 2-amino-1H-imidazol-4(5H)-ones e.g., II via iodine mediated intramol. cyclodeselenization of intermediate selenourea tethered amides/peptides was described. The method employs selenophilic ability of environmentally benign iodine to effect the deselenization at room temperature, thereby avoiding harsh conditions that are generally employed in the synthesis of iminohydantoins. Significantly 2-(N-alkylamino)-1H-imidazol-4(5H)-ones and 2-iminohydantoin conjugates of ditripeptide I and tripeptide III could be synthesized. Other advantages of the method include mild condition, short duration, wide substrate scope, simple workup and purification of the products.

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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《The specificity of leucine aminopeptidase》. Authors are Smith, Emil L.; Slonim, N. Balfour.The article about the compound:H-Leu-NH2.HClcas:10466-61-2,SMILESS:N[C@@H](CC(C)C)C(N)=O.[H]Cl).HPLC of Formula: 10466-61-2. Through the article, more information about this compound (cas:10466-61-2) is conveyed.

A highly purified preparation of leucine aminopeptidase (I) from hog intestinal mucosa, activated by Mn++ or Mg++, was found to hydrolyze only a single peptide bond of glycyl-L-leucinamide. The purification procedure of Smith and Bergmann (C.A. 38, 4965.7) was supplemented by precipitation with 33% acetone at room temperature followed by dialysis and removal of precipitate Since glycyl-L-leucine is not hydrolyzed by I, hydrolysis is thought to occur at the terminal peptide bond. I is devoid of endopeptidase activity. Compounds with free NH2 groups, such as L-leucyl-L-glutamic acid and L-glutamyl-L-leucinamide, are readily hydrolyzed, the latter compound only at one peptide bond. L-Leucylglycylglycine and L-leucylglycine are hydrolyzed most rapidly, whereas L-leucyl-L-glutamic acid is acted upon more slowly. Glycylglycyl-DL-leucylglycine is hydrolyzed very slowly. It is pointed out that in view of these findings the concept of the aminoexopeptidase must be amended to the extent that the free NH2 group need not be present on the amino acid residue which possesses the sensitive peptide bond. The synthesis of a number of aminopeptidase substrates is described. A simple synthesis for L-leucinamide-HCl by amidation of L-leucine methyl ester-HCl is reported. Glycyl-L-leucinamide-HCl ([α]26D = -19.0° (5% solution in water)) was synthesized from carbobenzoxyglycyl-L-leucine methyl ester. Syntheses for L-glutamyl-L-leucinamide ([α]27D = +6.7° (2.1% in water)) from carbobenzoxy-L-glutamyl anhydride and L-leucine methyl ester and for L-leucyl-L-glutamic acid ([α]24D = +10.5° (2% in M HCl)) from carbobenzoxy-L-leucine hydrazide are reported.

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Synthetic Route of C6H15ClN2O. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: H-Leu-NH2.HCl, is researched, Molecular C6H15ClN2O, CAS is 10466-61-2, about Peptide synthesis using carbamoylmethyl esters as acyl donors mediated by Bacillus amyloliquefaciens protease. Author is Miyazawa, Toshifumi; Shindo, Tadamichi; Murashima, Takashi; Yamada, Takashi.

Bacillus amyloliquefaciens protease-catalyzed peptide bond formation was investigated using the carbamoylmethyl (Cam) ester as the acyl donor. A series of N-protected L-amino acid Cam esters were coupled with an L-amino acid amide in acetonitrile in good to excellent yields. The superiority of the Cam ester for segment condensations was demonstrated in several 2 + 1 couplings. Furthermore, the couplings of racemic amino acid Cam esters as carboxyl components afforded the L-L-peptides in a highly diastereoselective manner.

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 10466-61-2, is researched, SMILESS is N[C@@H](CC(C)C)C(N)=O.[H]Cl, Molecular C6H15ClN2OJournal, Article, Research Support, U.S. Gov’t, P.H.S., Bioorganic & Medicinal Chemistry called Synthesis and Biological Properties of Amino Acid Amide Ligand-Based Pyridinioalkanoyl Thioesters as Anti-HIV Agents, Author is Song, Yongsheng; Goel, Atul; Basrur, Venkatesha; Roberts, Paula E. A.; Mikovits, Judy A.; Inman, John K.; Turpin, Jim A.; Rice, William G.; Appella, Ettore, the main research direction is pyridinioalkanoyl thioester preparation antiAIDS AIDS HIV structure activity antiviral.Application of 10466-61-2.

Hyper-mutable retroviruses such as HIV can become rapidly resistant to drugs used to treat infection. Strategies for coping with drug-resistant strains of virus include combination therapies, using viral protease and reverse transcriptase inhibitors. Another approach is the development of antiviral agents that attack mutationally nonpermissive targets that have functions essential for viral replication. Thus, the highly conserved nucleocapsid protein, NCp7, was chosen as a prime target in our search for novel anti-HIV agents that can overcome the problem of viral drug resistance. Recently, we reported (J. Med. Chem. 1999, 42, 67) a novel chemotype, the pyridinioalkanoyl thioesters (PATEs), based on 2-mercaptobenzamides as the thiol component and having its amide nitrogen substituted with various phenylsulfonyl moieties. These compounds were identified as relatively nontoxic anti-HIV agents in the XTT cytoprotection assay. In this study, we wish to report a sep. genre of active PATEs wherein the thiol component consists of an N-2-mercaptobenzoyl-amino acid derivative Active derivatives (EC50 < 10 μM) reported herein were confined to amino acid primary amides or Me amides having side chains no larger than iso-Bu. Amino acids terminating in free carboxyl or carboxylic acid ester groups were mostly inactive. Selected compounds were shown to be active on chronically infected CEM/SK-1, TNFα-induced U1, ACH-2 cells and virucidal on cell-free virus, latently infected U1 cells and acutely infected primary peripheral blood mononuclear cells (PBMCs). As far as I know, this compound(10466-61-2)Application of 10466-61-2 can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, U.S. Gov’t, Non-P.H.S., Research Support, U.S. Gov’t, P.H.S., Biopolymers called Synthesis and structural stability of helichrome as an artificial hemeproteins, Author is Sasaki, Tomikazu; Kaiser, Emil Thomas, which mentions a compound: 10466-61-2, SMILESS is N[C@@H](CC(C)C)C(N)=O.[H]Cl, Molecular C6H15ClN2O, Recommanded Product: H-Leu-NH2.HCl.

A detailed procedure is described for the synthesis of helichrome, which is the first successful example of polypeptide-based artificial hemeprotein. Boc-Ala-Glu(OCH2Ph)-Glu-Leu-Leu-Gln-Glu(OCH2Ph)-Leu-NH2 (Boc = Me3CO2C) was Boc-deblocked and then coupled with Boc-Ala-Glu(OCHiPh)-Glu-Leu-Leu-Glu-Glu(OCH2Ph)-OH by Me2N(CH2)3N:C:NEt.HCl/1-hydroxybenzotriazole to give Boc-Ala-Glu(OCH2Ph)-Glu-Leu-Leu-Gln-Glu(OCH2Ph)-Ala-Glu(OCH2Ph)-Glu-Leu-Leu-Glu-Glu(OCH2Ph)-Leu-NH2 (I). I was Boc-deblocked and coupled with the tetrasuccinimido ester of coproporphyrin I (II) to give the protected helichrome, which was deblocked by CF3SO3SiMe3/thioanisole to give the helichrome. The unfolding transition of the α-helical conformation of helichrome induced by guanidine hydrochloride was studied to understand the stability and dynamics of the folded structure. The resulting parameters (C0.5 = 5.2M and ΔGH2O = 4.4 kcal mol-1) characterizing helichrome denaturation were comparable to that of native globular proteins.

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