Can You Really Do Chemisty Experiments About cis-Cyclohexane-1,2-diamine

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To investigate the relationship between the molecular structure and biological activity of polypyridyl RuII complexes, such as DNA binding, photocleavage ability, and DNA topoisomerase and RNA polymerase inhibition, six new [Ru(bpy)2(dppz)]2+ (bpy=2,2′-bipyridine; dppz=dipyrido[3,2-a:2,’,3′-c]phenazine) analogs have been synthesized and characterized by means of 1H-NMR spectroscopy, mass spectrometry, and elemental analysis. Interestingly, the biological properties of these complexes have been identified to be quite different via a series of experimental methods, such as spectral titration, DNA thermal denaturation, viscosity, and gel electrophoresis. To explain the experimental regularity and reveal the underlying mechanism of biological activity, the properties of energy levels and population of frontier molecular orbitals and excited-state transitions of these complexes have been studied by density-functional theory (DFT) and time-depended DFT (TDDFT) calculations. The results suggest that DNA intercalative ligands with better planarity, greater hydrophobicity, and less steric hindrance are beneficial to the DNA intercalation and enzymatic inhibition of their complexes. Copyright

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New piperazinones are obtained in satisfactory yields by reaction of 1,2-diaza-1,3-butadienes with 1,2-diamines under solvent-free conditions. In polar solvents, the same reagents give rise to interesting dihydropyrazines and then to pyrazines by oxidation with PTAB or Pd/C. Georg Thieme Verlag Stuttgart.

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Top Picks: new discover of cis-Cyclohexane-1,2-diamine

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The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.1436-59-5, Name is cis-Cyclohexane-1,2-diamine, molecular formula is C6H14N2. In a Article,once mentioned of 1436-59-5, Quality Control of: cis-Cyclohexane-1,2-diamine

(Figure Presented) Converting CO2 into polymer: A catalytic system that produces a high molecular weight CO2/propylene oxide copolymer with high activity and selectivity is disclosed. After filtration through silica gel, elution of the catalyst leaves a solid phase with a negligible metal residue (see picture). The catalyst can be reused without significant loss of performance.

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Reference:
Chiral Catalysts,
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Can You Really Do Chemisty Experiments About cis-Cyclohexane-1,2-diamine

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Heterocyclic derivatives of naphthoquinones were synthesized via their 2-bromo-2,3-dehydro-intermediates. This new route may lead to the formation of benzo[a]phenothiazin-5-ones, benzo[f]quinoxalin-6-ones as well as their 1,4 (or 7,10) dihydroxy-derivatives in high yields. The possible mechanisms involved in the formation of these compounds are discussed.

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Chiral Catalysts,
Chiral catalysts – SlideShare

Discovery of cis-Cyclohexane-1,2-diamine

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Electric Literature of 1436-59-5. Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. Like 1436-59-5, Name is cis-Cyclohexane-1,2-diamine. In a document type is Article, introducing its new discovery.

Racemic as well as enantiomerically pure trans-1,1?-(cyclohexane-1,2-diyl)bis(imidazole N-oxides) were prepared from trans-cyclohexane-1,2-bis(methylidenamine) and 1,2-dione monooximes (alpha-hydroxyiminoketones). The enantiomeric purity of selected products was determined by means of 1H NMR spectroscopy in the presence of (+)-(R)-(tert-butyl)(phenyl)phosphonothioic acid as a chiral solvating agent. Deoxygenation by treatment with Raney-nickel led to the corresponding chiral bis-imidazoles.

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Chiral Catalysts,
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Reference of 1436-59-5, Chemistry can be defined as the study of matter and the changes it undergoes. You’ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology.1436-59-5, Name is cis-Cyclohexane-1,2-diamine, molecular formula is C6H14N2. In a patent, introducing its new discovery.

The present invention refers to the presence of a transition metal catalyst it is a car which will know and N- Hydroxy compound in the organic solvent and agitating amide bonds including peptide manufacturing method relates to manufacturing method of an amide compound, the present invention is a nucleophilic and electrophilic reaction by amide-covered with a polar depending on its reactivity of phosphorus and transition metal the car which will know without coordinating exhibits excellent chemical selectivity based on reactive derived from reactions. In addition, peptide synthesis in consuming protecting group removed and reaction step the reaction does not require substrate are connected with a polypeptide-based compound represented by synthesizing very effective 100% starting material during the reaction as well as a compromised immune system since it does have atomic diameter number. (by machine translation)

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Chiral Catalysts,
Chiral catalysts – SlideShare

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In an article, published in an article, once mentioned the application of 1436-59-5, Name is cis-Cyclohexane-1,2-diamine,molecular formula is C6H14N2, is a conventional compound. this article was the specific content is as follows.Application In Synthesis of cis-Cyclohexane-1,2-diamine

(±)-trans-1,2-Diaminocyclohexane has been found to crystallise from n-hexane at -10C as a conglomerate (space group P21212, Z = 2), which offers a possibility of resolving (±)-1 by an entrainment procedure, whereas (±)-1·H2SO4 forms heterochiral crystals (space group Pbca, Z = 8).

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Chiral Catalysts,
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The synthesis, spectroscopic characterization, cytotoxic activity and DNA binding evaluation of seven new dinuclear platinum(ii) complexes Pt1-Pt7, with the general formula [{Pt(L)Cl}2(mu-1,5-nphe)](ClO4)2 (1,5-nphe is 1,5-naphthyridine; while L is two ammines (Pt1) or one bidentate coordinated diamine: ethylenediamine (Pt2), (±)-1,2-propylenediamine (Pt3), trans-(±)-1,2-diaminocyclohexane (Pt4), 1,3-propylenediamine (Pt5), 2,2-dimethyl-1,3-propylenediamine (Pt6), and 1,3-pentanediamine (Pt7)), were reported. In vitro cytotoxic activity of these complexes was evaluated against three tumor cell lines, murine colon carcinoma (CT26), murine mammary carcinoma (4T1) and murine lung cancer (LLC1) and two normal cell lines, murine mesenchymal stem cells (MSC) and human fibroblast (MRC-5) cells. The results of the MTT assay indicate that all investigated complexes have almost no cytotoxic effects on 4T1 and very low cytotoxicity toward LLC1 cell lines. In contrast to the effects on LLC1 and 4T1 cells, complexes Pt1 and Pt2 had significant cytotoxic activity toward CT26 cells. Complex Pt1 had a much lower IC50 value for activity on CT26 cells compared with cisplatin. In comparison with cisplatin, all dinuclear Pt1-Pt7 complexes showed lower cytotoxicity toward normal MSC and MRC-5 cells. In order to measure the amount of platinum(ii) complexes taken up by the cells, we quantified the cellular platinum content using inductively coupled plasma mass spectrometry (ICP-QMS). Molecular docking studies performed to evaluate the potential binding mode of dinuclear platinum(ii) complexes Pt1-Pt7 and their aqua derivatives W1-W7, respectively, at the double stranded DNA showed that groove spanning and backbone tracking are the most stable binding modes.

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A multicomponent reaction of 1,3-dicarbonyls with 1,2-diamines and aromatic aldehydes is described for the direct stereoselective synthesis of 1,4-diazepane derivatives. Various reaction conditions were tested, including an efficient, user-friendly solvent- and catalyst-free procedure.

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Chiral Catalysts,
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When NiOx/Al2O3 catalysts (Ni wt% = 1.5) are prepared by impregnation using [NiL2(H2O)2]X2 as precursors (L = diamine, X = Cl- or NO3-), a supported oxidic or metallic phase can be selectively obtained after thermal treatment in N2 depending on the nature of the ligand and counter anion; the oxidic phase can be reduced at a lower temperature than the classical nickel aluminate phase obtained from [Ni-(H2O)6](NO3)2.

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Chiral Catalysts,
Chiral catalysts – SlideShare