Discovery of cis-Cyclohexane-1,2-diamine

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The title compound, C20H22N2O2, is C2 symmetric with the two N atoms bonded to salicylidene groups which are trans with respect to the cyclohexane ring.

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We have adopted the concept of ?cage to frameworks? to successfully produce a Na?N connected coordination networked cage Na-NC1 by using a [3+6] porous imine-linked organic cage NC1 (Nanjing Cage 1) as the precursor. It is found that Na-NC1 exhibits hierarchical porosity (inherent permanent voids and interconnected channel) and gas sorption measurements reveal a significantly enhanced CO2 uptake (1093 cm3 g?1 at 23 bar and 273 K) than that of NC1 (162 cm3 g?1 under the same conditions). In addition, Na-NC1 exhibits very low CO2 adsorption enthalpy making it a good candidate for porous materials with both high CO2 storage and low adsorption enthalpy.

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A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 1436-59-5, Name is cis-Cyclohexane-1,2-diamine, molecular formula is C6H14N2. In a Article,once mentioned of 1436-59-5, Safety of cis-Cyclohexane-1,2-diamine

A highly efficient, elegant and simple procedure with exceptionally mild conditions has been proposed for the synthesis of beta-amino-acrylate derivatives and an array of biologically and pharmaceutically active benzoheterocycles. The protocol offers a valuable alternative to known methods and will find applications in the field of green synthesis. The regio- and stereo-chemistry of the products were established by IR, NMR and single crystal X-ray analysis. The Royal Society of Chemistry.

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In spite of the importance of ligand/ copper-catalyzed arylations of nucleophiles in organic chemistry, the structural and electronic features that make a ligand efficient in these reactions have not been determined until now. In this work, several bidentate ligands involving pyridine and/or imine nitrogen binding sites such as our lead ligand 1 have been synthesized, and tested in phenol arylations with a view to highlight relationships between the structure of the chelates and their efficacy. This study allowed us to more precisely define the role of each type of N-binding site during the catalytic process, and to discover new efficient ligands. Among them, the iminopyridine 6a, which is cheap and easy-to-prepare in high yield, is very attractive for industrial applications. Some examples of its field of application are presented here. In the future, the development of this work could allow a more rational design of efficient ligands in arylation reactions, without resorting to classical ligand screening.

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Processes for preparing bis(urea-urethane) compounds wherein R1 is alkyl, aryl, arylalkyl, or alkylaryl, R2 is alkylene, arylene, arylalkylene, or alkylarylene, R3 is alkylene, arylene, arylalkylene, or alkylarylene, and R4 is hydrogen or alkyl, comprising: (1) first bring to a reaction temperature of about 20-125 C. a reaction mixture comprising monoalcohol reactant R1?OH and diisocyanate reactant OCN?R2?NCO, the monoalcohol being present in an amount of about 0.8-1.2 moles monoalcohol per mole diisocyanate, the monoalcohol and diisocyanate reactants being admixed in a solvent, the reactants and solvent being present in relative amounts of at least about 1 milliliter solvent per millimole diisocyanate, the reaction temperature continuing until reaction between the monoalcohol and the diisocyanate is complete; and (2) subsequent to step (1), adding to the reaction mixture diamine without isolating the reaction product of step (1), thereby forming compound of the formula in desirably high yield and purity.

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Disclosed are a category of platinum compounds having amino- or alkylamino-containing succinato derivatives as leaving group, or pharmaceutically acceptable salts thereof, preparation method thereof, and medicinal compositions containing the compounds. Also disclosed is a use of the compounds in treating cell proliferative diseases, especially cancers. The platinum compounds of the present invention have high water solubility and small toxic side effect.

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(Chemical Equation Presented) An axially chiral 1,8-dipyridylnaphthalene N,N?-dioxide has been employed in enantioselective fluorescence analysis of the enzymatic kinetic resolution of trans-1,2-diaminocyclohexane. The procedure eliminates cumbersome purification and derivatization steps required by traditional methods. The results demonstrate the potential of fluorescence spectroscopy using suitable chiral chemosensors for real-time analysis of the enantiomeric composition of chiral compounds and for high-throughput screening of asymmetric reactions.

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A compound of the formula:wherein???R1and R2are both hydrogen and R3and R4together with the carbon atoms in the tetraazacyclododecane macrocycle to which they are attached form a fused fully or partially saturated non aromatic cyclohexyl ring which may be unsubstituted or substituted by one or more halogen, straight or branched (C1-C5)alkyl, alkyl oxide of formula -R-OR wherein each R is a straight or branched (C1-C5)alkyl, hydroxy or hydroxyalkyl groups, and which may be further fused to a phenyl or cyclohexyl ringp is 0 or 1 and R6is hydrogen or a straight or branched (C1-C5) alkyl group; or a salt thereof and the metal chelates thereof, particularly gadolinium chelates, the pharmaceutical and diagnostic compositions containing them and their use in MRI.

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Disclosed are trans-1,2-cyclohexane bis(urea-urethane) compounds of the formulae wherein R1 and R?1 each, independently of the other, is an alkylene group, an arylene group, an arylalkylene group, or an alkylarylene group, R2 and R?2 each, independently of the other, is an alkyl group, an aryl group, an arylalkyl group, or an alkylaryl group, R3 and R?3 each, independently of the other, is a hydrogen atom or an alkyl group, R4 and R?4 each, independently of the other, is a hydrogen atom, a fluorine atom, an alkyl group, or a phenyl group, n is an integer of 0, 1, 2, 3, or 4, and R5 is an alkyl group, an aryl group, an arylalkyl group, an alkylaryl group, or a substituent other than an alkyl, aryl, arylalkyl, or alkylaryl group.

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The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.1436-59-5, Name is cis-Cyclohexane-1,2-diamine, molecular formula is C6H14N2. In a Article,once mentioned of 1436-59-5, Application In Synthesis of cis-Cyclohexane-1,2-diamine

Catalyst/HypoGen pharmacophore modeling approach and three-dimensional quantitative structure-activity relationship (3D-QSAR)/comparative molecular similarity indices analysis (CoMSIA) methods have been successfully applied to explain the cytotoxic activity of a set of 51 natural and synthesized naphthoquinone derivatives tested in human promyelocytic leukemia HL-60 cell line. The computational models have facilitated the identification of structural elements of the ligands that are key for antitumoral properties. The four most salient features of the highly active beta-cycled-pyran-1,2-naphthoquinones [0.1 muM < IC50 < 0.6 muM] are the hydrogen-bond interactions of the carbonyl groups at C-1 (HBA1) and C-2 (HBA2), the hydrogen-bond interaction of the oxygen atom of the pyran ring (HBA3), and the interaction of methyl groups (HYD) at the pyran ring with a hydrophobic area at the receptor. The moderately active 1,4-naphthoquinone derivatives accurately fulfill only three of these features. The results of our study provide a valuable tool in designing new and more potent cytotoxic analogues. The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 1436-59-5 is helpful to your research., Application In Synthesis of cis-Cyclohexane-1,2-diamine

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Chiral Catalysts,
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