Category: 1436-59-5

Related Products of 1436-59-5. Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 1436-59-5, Name is cis-Cyclohexane-1,2-diamine. In a document type is Article, introducing its new discovery.

Carbamoylphosphonate matrix metalloproteinase inhibitors 6: cis-2-aminocyclohexylcarbamoylphosphonic acid, a novel orally active antimetastatic matrix metalloproteinase-2 selective inhibitor-synthesis and pharmacodynamic and pharmacokinetic analysis

cis-2-Aminocyclohexylcarbamoylphosphonic acid (cis-ACCP) was evaluated in vitro and in two in vivo cancer metastasis models. It reduced metastasis formation in mice by ?90% when administered by a repetitive once daily dosing regimen of 50 mg/kg via oral or intraperitoneal routes and was nontoxic up to 500 mg/kg, following intraperitoneal administration daily for two weeks. Pharmacokinetic investigation of cis-ACCP in rats revealed distribution restricted into the extracellular fluid, which is the site of action for the antimetastatic activity and rapid elimination (t1/2 ? 19 min) from blood. Sustained and prolonged absorption (t1/2 ?126 min) occurred via paracellular mechanism along the small and large intestine with overall bioavailability of 0.3%. The in vivo concentrations of cis-ACCP in the blood in rats was above the minimal concentration for antimetastatic/MMP- inhibitory activity, thus explaining the prolonged action following once daily administration. Finally, 84% of the intravenously administered cis-ACCP to rats was excreted intact in the urine.

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In an article, published in an article, once mentioned the application of 1436-59-5, Name is cis-Cyclohexane-1,2-diamine,molecular formula is C6H14N2, is a conventional compound. this article was the specific content is as follows.SDS of cas: 1436-59-5

Intermetallic bonds in metallophilic mercuraazametallamacrocycles of synthetic design

22-Membered mercuraazametallamacrocycles 6, 7, and 12 have been synthesized by dipodal condensation (2 + 2) of bis(o-formylphenyl)mercury (11) and 1,2-disubstituted amines. Reduction of macrocycle 6 with sodium borohydride afforded novel 11-membered mercuraazametallamacrocycle 13. Macrocycle 6, when treated with [Cu(CH3CN)4]ClO4 and Cu(OCOCH 3)2/NH4PF6, formed orange-colored CuI complexes 14 ([6¡¤Cu]ClO4) and 15 ([6¡¤Cu]PF6), respectively, whereas red-colored complex 16 ([12¡¤Cu]ClO4) was obtained from the reaction of 12 with [Cu(CH3CN)4]ClO4. Similarly, complexes 17 ([6¡¤Ag]ClO4) and 18 ([6¡¤Ag]PF6) were synthesized by the reaction of 6 with the corresponding silver salts. The reaction of 6 with Hg(OCOCH3)2/NH4PF 6 led to the formation of hydroxo-bridged complex 19. The reaction of macrocycle 7 with Pd(C6H5CN)2Cl2 gave access to novel complex 9a. The macrocycles and the complexes have been characterized by elemental analysis, NMR (1H, 13C, 199Hg), fluorescence spectroscopy, and cyclic voltammetry. The molecular structures of organomercury precursors Hg{1-C6H 4-2-(CH2OH)}2 (10) and Hg{1-C6H 4-2-(CHO)}2 (11) and macrocycles 6, 7, and 12 show almost linear geometry around mercury; however, 13 shows a bent structure, i.e., significant deviation of the C-Hg-C angle from linearity. 22-Membered mercuraazametallamacrocycles 6, 7, and 12 are stabilized by secondary Hg…N intramolecular interaction and have an “hour-glass”-like conformation. The molecular structures of 14, 17, and 9a showed metallophilic interactions. The metal ions (CuI and AgI) are coordinated not only to the four nitrogens but also to two mercury atoms, forming a distorted octahedral geometry around the metal ions.

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1436-59-5, Name is cis-Cyclohexane-1,2-diamine, molecular formula is C6H14N2, belongs to chiral-catalyst compound, is a common compound. In a patnet, once mentioned the new application about 1436-59-5, HPLC of Formula: C6H14N2

Synthesis and SOD activity of manganese complexes of substituted pyridino pentaaza macrocycles that contain axial auxiliary

New manganese(II) complexes of substituted pyridino pentaaza macrocyclic ligands were prepared. The amino-, carboxy-, or other functional groups were placed in the vicinity of the axial position of the metal complex. Their SOD-like activity was determined by cytochrome c assay and compared with one another. The activities of pyridine analogs (12a-b and 13) and m-substituted analogs (12c and 12j) were similar and significantly better than that of the standard compound M-40403. The most potent compound was an o-aminobenzoyl derivative 12i, while the o-carboxybenzoyl analog 12d was the lowest active compound.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.HPLC of Formula: C6H14N2. In my other articles, you can also check out more blogs about 1436-59-5

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Electric Literature of 1436-59-5. Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 1436-59-5, Name is cis-Cyclohexane-1,2-diamine

Reaction of alkynyl alkoxy metal carbene complexes with 1,2-diamines

Reaction of alkynyl alkoxy carbenes 1 with 1,2-primary and secondary diamines is discussed. The descriptions of mono and biscarbene amino complexes and the effect of the reaction conditions, esteric and electronic factors on the product distribution are also discussed. Changes in the reaction conditions were found to effect greatly the resulting products.

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A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 1436-59-5, Name is cis-Cyclohexane-1,2-diamine, molecular formula is C6H14N2. In a Article£¬once mentioned of 1436-59-5, Recommanded Product: 1436-59-5

Synthesis and evaluation of series of diazine-bridged dinuclear platinum(II) complexes through in vitro toxicity and molecular modeling: Correlation between structure and activity of pt(II) complexes

Polynuclear Pt(II) complexes are a novel class of promising anticancer agents with potential clinical significance. A series of pyrazine (pz) bridged dinuclear Pt(II) complexes with general formulas {[Pt(L)Cl]2(mu-pz)}2+ (L, ethylenediamine, en; (¡À)-1,2-propylenediamine, 1,2-pn; isobutylenediamine, ibn; trans-(¡À)-1,2-diaminocyclohexane, dach; 1,3-propylenediamine, 1,3-pd; 2,2-dimethyl-1,3-propylenediamine, 2,2-diMe-1,3-pd) and one pyridazine (pydz) bridged {[Pt(en)Cl]2(mu-pydz)}2+ complex were prepared. The anticancer potential of these complexes were determined through in vitro cytotoxicity assay in human fibroblasts (MRC5) and two carcinoma cell lines (A375 and HCT116), interaction with double stranded DNA through in vitro assay, and molecular docking study. All complexes inhibited cell proliferation with inhibitory concentrations in the 0.5-120 muM range. While {[Pt(1,3-pd)Cl]2(mu-pz)}2+ showed improved activity and {[Pt(en)Cl]2(mu-pydz)}2+ showed comparable activity to that of clinically relevant cisplatin, {[Pt(en)Cl]2(mu-pydz)}2+ was less toxic in an assay with zebrafish (Danio rerio) embryos, causing no adverse developmental effects. The in vitro cytotoxicity of all diazine-bridged dinuclear Pt(II) complexes is discussed in correlation to their structural characteristics.

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The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.1436-59-5, Name is cis-Cyclohexane-1,2-diamine, molecular formula is C6H14N2. In a Article£¬once mentioned of 1436-59-5, Formula: C6H14N2

The role of chelating diamine ligands in the Goldberg reaction: A kinetic study on the copper-catalyzed amidation of aryl iodides

The mechanistic details of the Cu-catalyzed amidation of aryl iodides are presented. The kinetic data suggest that the diamine ligand prevents multiple ligation of the amide. The formation of an amidocuprate species external to the catalytic cycle helped to rationalize the dependence on diamine concentration and the inverse dependence on amide concentration at low diamine concentrations. The intermediacy of a Cu(I) amidate was established through both its chemical and kinetic competency. Copyright

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 1436-59-5 is helpful to your research., Formula: C6H14N2

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Synthesis and structure elucidation of pyrimidobenzimidazoles and fused derivatives II [1]. Dodecahydrobenzimidazo-[2,1-b]quinazolines and decahydrobenzimidazo-[2,1-b]benzo[h]quinazolines [2]

The cyclization reactions of trans-3a-hexahydro-2-benzimidazolamine with 2-alkylidene-and 2-benzylidenecyclohexanones and alpha-tetralones, respectively, yield mixtures of two isomeric condensates each. Thorough high resolution NMR analyses (1H and 13C NMR, HH-COSY, gs-HSQC, gs-HMBC, 1D TOCSY, and 1D NOE difference spectra) revealed that the corresponding isomers are in all cases linearly fused diastereomeric 12alpha-and 12beta-substituted trans-6aalpha-dodecahydrobenzimidazo[2,1-b]quinazolines and 7alpha-substituted trans-8abeta-and trans-8aalpha-decahydrobenzimidazo[2,1-b]benzo[h]quinazolines, respectively. The formation of corresponding angularly fused regioisomers was not observed so far. The stereochemistry and the tautomerism of some bases and their hydrochlorides as well as the regiospecific course of the cyclization reactions are discussed. Biological tests showed that the novel compounds don’t exert remarkable antibacterial and antimycotic effects.

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In an article, published in an article, once mentioned the application of 1436-59-5, Name is cis-Cyclohexane-1,2-diamine,molecular formula is C6H14N2, is a conventional compound. this article was the specific content is as follows.Recommanded Product: cis-Cyclohexane-1,2-diamine

Nano-zinc coordination with the ligands of carboplatin, oxaliplatin and nedaplatin. Synthesis, characterization and biological properties

The replacement of platinum in carboplatin, oxaliplatin and nedaplatin by zinc metal (in bulk and nano-scalled) produces biologically active compounds with increased solubility in water. We compared, in this work, three synthesized zinc-complexes from the ligands of platinum-anticancer drugs. The structural characterization of the products has been determined on the basis of their atomic absorption spectroscopy, elemental analysis, FT-IR, 1H and 13C NMR spectra. The crystalline structure and morphology of the products have been shown by XRD and SEM techniques. The antibacterial activities of the complexes have been examined through the growth inhibitory zone and minimal inhibitory concentrations.

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Reference of 1436-59-5. Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 1436-59-5, Name is cis-Cyclohexane-1,2-diamine. In a document type is Article, introducing its new discovery.

Carbamoylphosphonate matrix metalloproteinase inhibitors 6: cis-2-aminocyclohexylcarbamoylphosphonic acid, a novel orally active antimetastatic matrix metalloproteinase-2 selective inhibitor-synthesis and pharmacodynamic and pharmacokinetic analysis

cis-2-Aminocyclohexylcarbamoylphosphonic acid (cis-ACCP) was evaluated in vitro and in two in vivo cancer metastasis models. It reduced metastasis formation in mice by ?90% when administered by a repetitive once daily dosing regimen of 50 mg/kg via oral or intraperitoneal routes and was nontoxic up to 500 mg/kg, following intraperitoneal administration daily for two weeks. Pharmacokinetic investigation of cis-ACCP in rats revealed distribution restricted into the extracellular fluid, which is the site of action for the antimetastatic activity and rapid elimination (t1/2 ? 19 min) from blood. Sustained and prolonged absorption (t1/2 ?126 min) occurred via paracellular mechanism along the small and large intestine with overall bioavailability of 0.3%. The in vivo concentrations of cis-ACCP in the blood in rats was above the minimal concentration for antimetastatic/MMP- inhibitory activity, thus explaining the prolonged action following once daily administration. Finally, 84% of the intravenously administered cis-ACCP to rats was excreted intact in the urine.

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Chiral Catalysts,
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In an article, published in an article, once mentioned the application of 1436-59-5, Name is cis-Cyclohexane-1,2-diamine,molecular formula is C6H14N2, is a conventional compound. this article was the specific content is as follows.Recommanded Product: 1436-59-5

Intermetallic bonds in metallophilic mercuraazametallamacrocycles of synthetic design

22-Membered mercuraazametallamacrocycles 6, 7, and 12 have been synthesized by dipodal condensation (2 + 2) of bis(o-formylphenyl)mercury (11) and 1,2-disubstituted amines. Reduction of macrocycle 6 with sodium borohydride afforded novel 11-membered mercuraazametallamacrocycle 13. Macrocycle 6, when treated with [Cu(CH3CN)4]ClO4 and Cu(OCOCH 3)2/NH4PF6, formed orange-colored CuI complexes 14 ([6¡¤Cu]ClO4) and 15 ([6¡¤Cu]PF6), respectively, whereas red-colored complex 16 ([12¡¤Cu]ClO4) was obtained from the reaction of 12 with [Cu(CH3CN)4]ClO4. Similarly, complexes 17 ([6¡¤Ag]ClO4) and 18 ([6¡¤Ag]PF6) were synthesized by the reaction of 6 with the corresponding silver salts. The reaction of 6 with Hg(OCOCH3)2/NH4PF 6 led to the formation of hydroxo-bridged complex 19. The reaction of macrocycle 7 with Pd(C6H5CN)2Cl2 gave access to novel complex 9a. The macrocycles and the complexes have been characterized by elemental analysis, NMR (1H, 13C, 199Hg), fluorescence spectroscopy, and cyclic voltammetry. The molecular structures of organomercury precursors Hg{1-C6H 4-2-(CH2OH)}2 (10) and Hg{1-C6H 4-2-(CHO)}2 (11) and macrocycles 6, 7, and 12 show almost linear geometry around mercury; however, 13 shows a bent structure, i.e., significant deviation of the C-Hg-C angle from linearity. 22-Membered mercuraazametallamacrocycles 6, 7, and 12 are stabilized by secondary Hg…N intramolecular interaction and have an “hour-glass”-like conformation. The molecular structures of 14, 17, and 9a showed metallophilic interactions. The metal ions (CuI and AgI) are coordinated not only to the four nitrogens but also to two mercury atoms, forming a distorted octahedral geometry around the metal ions.

Do you like my blog? If you like, you can also browse other articles about this kind. Recommanded Product: 1436-59-5. Thanks for taking the time to read the blog about 1436-59-5

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