03/9/2021 News The important role of cis-Cyclohexane-1,2-diamine

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The present invention provides a compound of the following formula (I): R3-NH-C(=X)-P(=O)OR1OR2including pharmaceutically acceptable salts, solvates, hydrates and polymorphs of the compounds of formula I, as well as geometrical isomers and optically activeforms of the compounds of formula I and pharmaceutically acceptable salts, solvates, hydrates and polymorphs of said isomers and forms, wherein R’ and R2 may be the same or different and are each selected from hydrogen, acyloxyalkyl and aryl or R1 and R2 may form together with the oxygen and phosphorus atoms a dioxaphosphacycloalkane ring; X is 0 or S; and R3 is selected, when X is 0, from bicycloalkyl, cycloalkylalkyl and substituted cycloalkyl by at least one of alkyl, amino, amidino and guanidino; and R3 is selected, when X is S, from bicycloalkyl, cycloalkylalkyl and cycloalkyl optionally substituted by at least one of alkyl, amino, amidino and guanidino; with the proviso that when X is O,R3 is not cyclohexylmethyl, and when X is S, R3is not cyclohexyl. The invention further provides pharmaceutical compositions comprising the above compounds and their use in medicine.

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Sep 2021 News Can You Really Do Chemisty Experiments About cis-Cyclohexane-1,2-diamine

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Racemic trans -cyclohexane-1,2-diamine was allowed to react with eleven aldehydes with different patterns of substitution at the aromatic ring, in the absence of solvent, by manually milling the reagents. The corresponding imines were obtained in moderated to high chemical yields, in only 10 minutes of reaction. A one-pot, two-step preparation of stable complexes of selected imines with Pd(OAc) 2 and Cu(OAc) 2 and the use of these complexes as catalysts in the aromatization of methyl 1-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxylate to the corresponding methyl 1-hydroxynaphthalene-2-carboxylates, is also reported.

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01/9/2021 News Discovery of cis-Cyclohexane-1,2-diamine

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One-step conversion including intramolecular hydrogen bond decomposition, aerobic oxidation, and condensation from alpha-hydroxyketones and 1,2-diamines into quinoxalines is reported using FeCl3 and morpholine as cocatalysts. Taylor & Francis Group, LLC.

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01/9/2021 News Can You Really Do Chemisty Experiments About cis-Cyclohexane-1,2-diamine

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A series of salen-type ligands (L1H2-L 6H2) with sterically bulky cumyl groups have been synthesized. Reaction of these ligands with AlMe3 yields the mononuclear aluminum complexes [LAlMe] (1-3) or dinuclear species [L 2Al2Me4] (4-6), respectively. Further reaction of [LAlMe] (1-3) with benzyl alcohol produces [LAl(OBn)] (1a-3a), respectively. Solid-state structural studies reveal that complexes 1a and 2a are mononuclear; however, complex 6 is a dinuclear species. Aluminum alkoxides 1a-3a are highly stereoselective in the ROP of rac-lactide, producing polylactide (PLA) with 94-97% enantiomeric selectivity (Pm) at high conversion. Their high enantioselectivity leads to PLA with high Tm (205 C). The polymerization of l-lactide by these complexes also shows good living features with narrow PDI values (Mw/Mn = 1.06-1.25) signaling less or no transesterification, which can be further verified by MALDI-TOF mass spectrometric analysis.

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1-Sep-2021 News Some scientific research about cis-Cyclohexane-1,2-diamine

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Two new Schiff base macrocycles – a 4+4 condensation product and a meso-type 2+2 condensation product – were obtained in a reaction of frans-1,2-diaminocyclohexane and 2,6-diformylpyridine. Reduction of these compounds led to the corresponding 4+4 and 2+2 macrocyclic amines. The macrocycles were characterised by NMR spectroscopy and electrospray mass spectrometry. The symmetry and stereochemistry of these macrocycles, as well as of new 3+3 and 4+4 diastereomers identified in solution, has been established. X-Ray structures of the 2+2 and 4+4 Schiff base macrocycles confirm the configurations determined on the basis of spectroscopic investigations. The crystal structures reveal that the centres of the square-shaped 4+4 macrocycles form channels as a result of columnar stacking. The Royal Society of Chemistry 2005.

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1-Sep-2021 News Extracurricular laboratory:new discovery of cis-Cyclohexane-1,2-diamine

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Kinetic studies of the synthesis of glycerol carbonate from glycidol and carbon dioxide have been carried out. These showed that under suitable reaction conditions, bimetallic aluminium(salen) complex 4 is able to catalyse the conversion of epoxides into the corresponding cyclic carbonates without the need for a co-catalyst.

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Ormaplatin ([Pt(dach)Cl4]) represents one of the three primary structural prototypes of Pt(iv) anticancer-active prodrugs. The reduction of ormaplatin by an extended series of thiols has been studied kinetically in a broad pH range. A novel and remarkable correlation between log:kRS- and the thiol dissociation constants pKRSH is disclosed: log:kRS- = (0.50 ± 0.02)pKRSH + (0.68 ± 0.13), where kRS- denotes the second-order rate constant of each thiolate towards the reduction of ormaplatin.

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Bulky ligands for cleft-type metal complexes were synthesized from thioketones and diamines in yields varying from 20 – 80 percent.A molecular structure determination of one ligand, N,N’-bis(12H-benzoxanthen-12-ylidene)-1,2-propanediamine (19), was performed.A metallo-cleft was constructed by a self-assembling process with zinc(II) chloride.A crystallographic study of this zinc complex (24) revealed surprisingly that an anti-syn inversion of the imine moieties of the ligand had taken place during complexation.

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Imidazo[4,5-c]pyridines were synthesized in three steps utilizing a palladium-catalyzed amidation/cyclization strategy. N-Aryl substrates were synthesized using copper-catalyzed amidation of 3-amino-N-Boc-4-chloropyridine. Complementary protocols for the selective chlorination of imidazo[4,5-c] pyridines at the C2 and C7 positions were also developed.

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Two novel heptadentate ligands, pentaaza macrocycles with two pendant xpyridyl and phenol groups, were prepared and the crystal structure of the manganese(II) complex of N,N?-bis(2-pyridylmethyl)-pentaaza macrocycle revealed a pentagonal bipyramidal geometry.

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Chiral Catalysts,
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