Category: 1436-59-5

1436-59-5, Name is cis-Cyclohexane-1,2-diamine, molecular formula is C6H14N2, belongs to chiral-catalyst compound, is a common compound. In a patnet, once mentioned the new application about 1436-59-5, Recommanded Product: 1436-59-5

In this manuscript, we describe the synthesis of new trans-N-sulfonamide platinum complexes and their antiproliferative activity (GI50, muM) in human solid tumors cells. The structure activity relationships (SAR), with different new synthesized complexes by variation in ligand, halogen and also in the stereochemistry of the ligand, has been studied. Solubility and stability studies have also been carried out as well as fluorescent cell assays in order to clarify the final target in the tumor cells.

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Chiral Catalysts,
Chiral catalysts – SlideShare

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.1436-59-5, Name is cis-Cyclohexane-1,2-diamine, molecular formula is C6H14N2. In a Patent，once mentioned of 1436-59-5, Product Details of 1436-59-5

A compound of formula (I), wherein R3, R4, G, B, M, and Z are as defined in the claims, and pharmaceutically acceptable salts thereof are disclosed. The compounds of formula (I) possess utility as FGFR inhibitors and are useful in the treatment of a condition, where FGFR kinase inhibition is desired, such as cancer.

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Reference：
Chiral Catalysts,
Chiral catalysts – SlideShare

Electric Literature of 1436-59-5, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 1436-59-5, Name is cis-Cyclohexane-1,2-diamine, molecular formula is C6H14N2. In a Article，once mentioned of 1436-59-5

A new chiral titanium reagent, derived from optically active trans-1,2- dicamphorsulfonamidocyclohexane 2a and Ti(O(i)Pr)4, was found to promote the enantioselective addition of diethylzinc to various aldehydes giving rise to the corresponding alcohols in high yields with moderate to high selectivity.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 1436-59-5 is helpful to your research., Electric Literature of 1436-59-5

Reference：
Chiral Catalysts,
Chiral catalysts – SlideShare

Electric Literature of 1436-59-5, An article , which mentions 1436-59-5, molecular formula is C6H14N2. The compound – cis-Cyclohexane-1,2-diamine played an important role in people’s production and life.

A series of novel beta-hydroxy-beta-bis(trifluoromethyl)-imines (2a-j) and di(beta-hydroxy-beta-bis(trifluoromethyl))-diimines (3a-f) were prepared in moderate to good yields via a simple two-step approach: first, beta-hydroxy-beta-bis(trifluoromethyl)-ketones (1a-c) were obtained by a catalyst-free aldol reaction between liquid hexafluoroacetone sesquihydrate and ketones (acetone, acetophenone, and pinacolone, respectively); then, condensation of the latter fluorinated beta-ketols 1a-c with primary amines or diamines was achieved in the presence of Lewis (montmorillonite, InBr3, La(OTf)3) or Bro?nsted (PTSA) acid catalysts. The molecular structures of mono- and di-beta-hydroxy-beta-bis(trifluoromethyl)-(di)imines 2e,h and 3a,f were determined and found to exhibit strong intramolecular {double bond, long}(R)N?H-O hydrogen bonding.

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Reference：
Chiral Catalysts,
Chiral catalysts – SlideShare

Application of 1436-59-5. Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. Like 1436-59-5, Name is cis-Cyclohexane-1,2-diamine. In a document type is Article, introducing its new discovery.

Chiral induction has been examined in the four diastereomeric products formed in a series of outer-sphere electron transfer reactions between the oxidants [Co(ox)3]3-, [Co(edta)]-, [Co(gly)(ox)2]2-, C1-cis(N)-[Co(gly)2(ox)]-, [Co(en)(ox)2]-, C2-cis(N)-[Co(gly)2(ox)]- and trans(N)-[Co(gly)2(ox)]- with [Co((RR,SS)-chxn)3]2+ and [Co((R, S)-pn)3]2+ as reductants. The products; [Co((RR,SS)-chxn)3-lel3]3+, [Co((RR,SS)-chxn)3-lel2ob]3+, [Co((RR,SS)-chxn)3-lelob2]3+, [Co((RR,SS)-chxn)3-ob3]3+ and corresponding species for [Co((R, S)-pn)3]3+ show patterns of selectivity which are analyzed in terms of the size and structure of the reactants. The presence of a pseudo-C3 carboxylate face on the oxidant enhances selectivity but the pattern is quite different for those oxidants that contain oxalate as one of their ligands compared with non-oxalate containing species such as [Co(edta)]-. A very simple model is developed in which the reductant employs a limited set of interactions corresponding to the major symmetry axes. The unrestricted reductant has very low aggregate selectvity. Steric and hydrogen bonding patterns in both oxidant and reductant enhance individual interactions resulting in the observed selectivities.

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Chiral Catalysts,
Chiral catalysts – SlideShare

Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn’t involve a screen. 1436-59-5, C6H14N2. A document type is Article, introducing its new discovery., Safety of cis-Cyclohexane-1,2-diamine

The reactions of pentafluoropyridine and 2,4,6-trifluoropyridine with a series of primary and secondary amines were studied. Whereas the nucleophilic aromatic substitution of pentafluoropyridine occurs with high regioselectivity in all cases, providing the expected 4-aminopyridine derivatives in excellent yields, the regioselectivity of 2,4,6-trifluoropyridine is dependent on the steric hindrance of the attacking nucleophile. Small nucleophiles such as morpholine attack the 4-position of the pyridine ring with high preference, but more bulky diamines attack the 2- and 4-positions leading to the formation of three regioisomeric products. (R,R)-1,2-Diaminocyclohexane as moderately bulky diamine reacted with 2,4,6-trifluoropyridine to afford the desired bis(4-aminopyridinyl)cyclohexane derivative in 30% yield. For hydrodefluorination two methods were examined. A two-step procedure employing hydrazine and subsequently copper(II) sulfate removed just one fluorine substituent, but is not sufficiently high yielding for the reduction of more complex substrates. With the system titanocene difluoride as pre-catalyst and diphenylsilane as reducing agent we were able to selectively remove fluorine substituents at positions C-2 and C-4 of a variety of 4-aminopyridine derivatives. This protocol allows the synthesis of compounds such as the divalent chiral 4-(dimethylamino)pyridine (DMAP) analogue (R,R)-trans-N,N’-dimethyl-N,N’-bis(pyridin-4-yl)cyclohexane-1,2-diamine with fair overall yield.

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Reference：
Chiral Catalysts,
Chiral catalysts – SlideShare

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.1436-59-5, Name is cis-Cyclohexane-1,2-diamine, molecular formula is C6H14N2. In a Article，once mentioned of 1436-59-5, Safety of cis-Cyclohexane-1,2-diamine

The compound N,N?-bis(2-hydroxycyclohexyl)-trans-cyclohexane-1,2-diamine (L1) and its complex with CuII have been prepared. The structure of [CuL1][ClO4]2 1 was determined. The Cu has a distorted octahedral co-ordination, with the four donor atoms provided by L1 giving Cu-N 1.985(7) and Cu-O 1.947(6) A. The oxygens from two perchlorates lie on the axial positions with Cu-O 2.749 A. The perchlorates are involved in a hydrogen bonding network holding layers of [CuL1]2+ cations together with bonds to the hydrogens of the co-ordinated hydroxyls of the cyclohexanediyl groups and the NH hydrogens. Alternating layers of [CuL1]2+ cations have the L1 ligand as the SRS and RSR enantiomers. Difficulty in obtaining a sufficiently large data set for L1 meant that R for this structure was not less than 0.13. The structure is thus not reported in any detail, but is sufficient to indicate the conformation of the ligand, which is used as the basis of a molecular mechanics generation of the structure. Both the copper(II) complex of L1 and L1 itself have only the RSR and SRS diastereomeric pair present in the structures, supporting the idea that syntheses involving reaction of cyclohexene oxide with polyamines result in considerable diastereoselectivity. The structure of 1 shows steric crowding, with van der Waals repulsion between hydrogens on adjacent cyclohexyl groups of the L1 ligand. This crowding becomes more severe as the metal ion becomes larger, which is related to the strong preference the ligand shows for smaller metal ions. This latter effect is indicated by the formation constants (log K1) of L1: CuII, 11.50; NiII, 6.84; ZnII, 4.77; CdII, 4.08; PbII, 4.80; in 0.1 mol dm-3 NaNO3 at 25C. The effect of cyclohexanediyl bridges on the stability of complexes formed by L1 is discussed in relation to the stability of complexes of similar ligands that have simple ethylene bridges between their donor atoms.

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Chiral Catalysts,
Chiral catalysts – SlideShare

Electric Literature of 1436-59-5, Chemistry can be defined as the study of matter and the changes it undergoes. You’ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology.1436-59-5, Name is cis-Cyclohexane-1,2-diamine, molecular formula is C6H14N2. In a patent, introducing its new discovery.

Two cyclohexanediamine-based tetrakisquinoline derivatives, N,N,N?,N?-tetrakis(2-quinolylmethyl)-trans-1,2-cyclohexanediamine (TQDACH) and N,N,N?,N?-tetrakis(1-isoquinolylmethyl)-trans-1,2- cyclohexanediamine (1-isoTQDACH), have been prepared and their zinc-induced fluorescent response was investigated. In DMF-H2O (1:1) solution, TQDACH exhibits increase of fluorescence at 455 nm in the presence of 1 eq. of zinc ion (lambdaex = 317 nm, = 0.010). Similarly, 1-isoTQDACH exhibited fluorescence enhancement upon binding with zinc (lambdaex = 325 nm, lambdaem = 352 and 475 nm, = 0.032). The fluorescence intensity ratio induced by cadmium relative to zinc (ICd/I Zn) for these 1,2-cyclohexanediamine probes is lower than those for the corresponding ethylenediamine derivatives, TQEN and 1-isoTQEN. Crystal structures of the zinc and cadmium complexes of TQDACH and 1-isoTQDACH reveal the superior metal binding ability of the 1,2-cyclohexanediamine and isoquinoline moieties in comparison to ethylenediamine and quinoline. The conformational restriction afforded by the 1,2-cyclohexanediamine skeleton upon zinc binding leads to enhanced fluorescence intensity and strong metal binding affinity. The Royal Society of Chemistry 2013.

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Reference：
Chiral Catalysts,
Chiral catalysts – SlideShare

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 1436-59-5, Name is cis-Cyclohexane-1,2-diamine, Safety of cis-Cyclohexane-1,2-diamine.

Two new C2 and D2 symmetrical dioxatetraaza 18-membered macrocycles [(R,R)-1 and (S,S,S,S)-2] are efficiently synthesized in enantiomerically pure forms by a chemoenzymatic method starting from (±)-trans-cyclohexane-1,2-diamine. The protonation constants and the binding constants with different chiral dicarboxylates are determined in aqueous solution by means of pH-metric titrations. The triprotonated form of (S,S,S,S)-2 shows moderate enantioselectivity with malate and tartrate anions (DeltaDeltaG = 0.62 and 0.66 kcal mol-1, respectively), being the strongest binding observed in both cases with the L enantiomer. Good enantiomeric discrimination is obtained with tetraprotonated (R,R)-1 and N-acetyl aspartate, the complex with the D-enantiomer being 0.92 kcal mol-1 more stable than its diastereomeric counterpart. Despite the lack of enantioselectivity of tri-and tetraprotonated (R,R)-1 for the tartrate anion, a very good diastereopreference for meso-tartrate is found. All these experimental results allow us to propose a model for the host-guest structure based on coulombic interactions and hydrogen bonds.

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Reference：
Chiral Catalysts,
Chiral catalysts – SlideShare

In an article, published in an article, once mentioned the application of 1436-59-5, Name is cis-Cyclohexane-1,2-diamine,molecular formula is C6H14N2, is a conventional compound. this article was the specific content is as follows.Product Details of 1436-59-5

A simple route for facile access of aryl(2-aminoaryl) sulfide was reported. With the aid of iron(III) chloride catalyst and diamine ligand, benzothiazole was efficiently S-arylated with various aryl iodides (19 examples) in water under air atmosphere. This operationally simple protocol provides aryl(2-aminoaryl) sulfides in moderate to good yields.

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Reference：
Chiral Catalysts,
Chiral catalysts – SlideShare