Some scientific research about (1R,2S)-(−)-2-Amino-1,2-diphenylethanol

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Studies toward the synthesis and characterization of a cationic NCN pincer platinum(II) aquo complex with a chiral bis(imidazolinyl)phenyl (Phebim) ligand are reported. During these studies, the new symmetrical Phebim-H ligands 1c,d and unsymmetrical hybrid oxazoline-imidazoline ligands 6a-c, as well as the related neutral symmetrical NCN pincer Pt(II) complexes 2b-d and 3a-d and unsymmetrical NCN? pincers 7a,b and 8c have been isolated and characterized. Despite considerable attempts, only one of the expected cationic chiral NCN pincer Pt(II) complexes (4), which contains water as an exchangeable neutral ligand for the Pt(II) center, was obtained in pure form from the reaction of the neutral Pt-I complex 3a with AgOTf in wet CH2Cl 2 at room temperature. In contrast, the cationic Pt(II) pyridine complexes 5a,c could be easily prepared in high yields from the reaction of the neutral Pt-Cl complexes 2a,c with AgOTf in the presence of pyridine in CH 2Cl2 at room temperature. The molecular structures of the neutral symmetrical Pt(II) complexes 2c,d and 3c,d and the unsymmetrical Pt(II) complex 7b as well as the cationic Pt(II) aquo complex 4 have been determined by X-ray single-crystal analysis. The cationic complexes 4 and 5a,c have been applied to the asymmetric Friedel-Crafts alkylation of indoles with nitroalkenes. Among them, the aquo complex 4 was found to be effective under the given reaction conditions. With a catalyst loading of 5 mol %, a variety of the nitroalkylated indoles were produced in good yields with moderate to good enantioselectivities (up to 83% ee).

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Chiral Catalysts,
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Using chiral 1,1?-binaphthylazepine-derived amino alcohol as catalyst, the direct addition of in situ prepared arylzinc (with triphenylboroxine as aryl source) to various aryl aldehydes can afford optically active diarylmethanols in high yields and enantioselectivities (up to 96%).

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Chiral Catalysts,
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Some scientific research about (1R,2S)-(−)-2-Amino-1,2-diphenylethanol

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Three types of supramolecular benzoheterocyclic host complexes were successfully prepared using (1R,2S)-2-amino-1,2-diphenylethanol and three types of benzoheterocyclic (benzothiophene, benzofuran, and benzopyrrole) acid derivatives. The host complexes had one-dimensional (1D) channel-like cavities that were formed by the assembly of two-component 21-helical columnar network structures, which included guest alcohol molecules. The release behavior of the guest molecules could be tuned by the type of heterocyclic ring in the supramolecular host complex.

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Reference:
Chiral Catalysts,
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The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.23190-16-1, Name is (1R,2S)-(−)-2-Amino-1,2-diphenylethanol, molecular formula is C6H5CH(NH2)CH(C6H5)OH. In a Article,once mentioned of 23190-16-1, name: (1R,2S)-(−)-2-Amino-1,2-diphenylethanol

Reported herein is a dual nickel- and photoredox-catalyzed modular approach for the preparation of enantioenriched N-benzylic heterocycles. alpha-Heterocyclic carboxylic acids, easily obtainable from common commercial material, are reported as suitable substrates for a decarboxylative strategy in conjunction with a chiral pyridine-oxazoline (PyOx) ligand, providing quick access to enantioenriched drug-like products. The presence of a directing group on the heterocyclic moiety is shown to be beneficial, affording improved stereoselectivity in a number of cases.

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Chiral Catalysts,
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A new application about (1R,2S)-(−)-2-Amino-1,2-diphenylethanol

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The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.23190-16-1, Name is (1R,2S)-(−)-2-Amino-1,2-diphenylethanol, molecular formula is C6H5CH(NH2)CH(C6H5)OH. In a Article,once mentioned of 23190-16-1, Formula: C6H5CH(NH2)CH(C6H5)OH

Novel chemically bonded chiral stationary phases (CSP’s) derived from (1R,2S)-2-carboxymethylamino-1,2-diphenylethanol and from (1S,2S)-2-carboxymethylamino-1,2-diphenylethanol were prepared.The ligand exchange chromatography on these CSP’s was found to be effective for the direct resolution of the enantiomers of amino acids.

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Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare

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Bifunctional asymmetric phase-transfer catalysts bearing multiple hydrogen-bonding donors have rarely been explored. The first quaternary ammonium type of these catalysts derived from cinchona alkaloids were readily prepared and found to be highly efficient catalysts for asymmetric nitro-Mannich reactions of amidosulfones. Compared with previous reports, very broad substrate generality was observed, and both enantiomers of the products were achieved in high enantio- and diastereoselectivity (90-99% ee, 13:1 to 99:1 dr).

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Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare

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(Chemical Equation Presented) Unusually sensitive: A chiral sensor based on 1,1?-bi-2-naphthol was prepared, which can provide visual enantioselective discrimination of alpha-hydroxycarboxylic acids. When the sensor and the acid have matched configurations, an enantioselective precipitation occurs, which is accompanied by a dramatic (over 950-fold) solidstate fluorescence enhancement (see picture).

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Chiral Catalysts,
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Disclosed are compounds which inhibit beta-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer’s disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits beta-amyloid peptide release and/or its synthesis.

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New explortion of (1R,2S)-(−)-2-Amino-1,2-diphenylethanol

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23190-16-1, Name is (1R,2S)-(−)-2-Amino-1,2-diphenylethanol, molecular formula is C6H5CH(NH2)CH(C6H5)OH, belongs to chiral-catalyst compound, is a common compound. In a patnet, once mentioned the new application about 23190-16-1, Formula: C6H5CH(NH2)CH(C6H5)OH

At 2.5 mol % loadings using reaction temperatures between 30-55 C, ortho-functionalized diaryl diselenides are highly effective organocatalytic oxidants for aerobic redox dehydrative amidic and peptidic bond formation using triethyl phosphite as a simple terminal reductant. This simple-to-perform organocatalytic reaction relies on the ability of selenols to react directly with dioxygen in air without recourse to metal catalysts. It represents an important step toward the development of a general, economical, and benign catalytic redox dehydration protocol.

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Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare

Discovery of (1R,2S)-(−)-2-Amino-1,2-diphenylethanol

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Diastereoselective Michael additions of 2-hydrogeno-2-oxo-1,4,2- oxazaphosphinanes to olefins were described. Phosphinopeptide compounds were obtained in very good yield (up to 90%) and diasteromeric excesses ranging from 26 to 78%. Copyright

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Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare