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Disclosed are compounds which inhibit beta-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer’s disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits beta-amyloid peptide release and/or its synthesis.

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Reference:
Chiral Catalysts,
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A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 23190-16-1, Name is (1R,2S)-(−)-2-Amino-1,2-diphenylethanol, molecular formula is C6H5CH(NH2)CH(C6H5)OH. In a Article,once mentioned of 23190-16-1, Recommanded Product: (1R,2S)-(−)-2-Amino-1,2-diphenylethanol

The asymmetric transfer hydrogenation of ketones using isopropyl alcohol (IPA) as hydrogen donor in the presence of novel manganese catalysts is explored. The selective and active systems are easily generated in situ from [MnBr(CO)5] and inexpensive C2-symmeric bisoxalamide ligands. Under the optimized reaction conditions, the Mn-derived catalyst gave higher enantioselectivity compared with the related ruthenium catalyst.

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Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare

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A catalytic route for enantioselective synthesis of homoallyl amines through Cu(II)-Schiff base catalyzed reaction of allyltin with aryl, alkenyl-substituted N-sulfonylimines is described. The allylation reaction is promoted by a simple in situ generated Cu(II )-amino alcohol based Schiff base complex. The addition of allyltin to aldimines delivers the desired products up to 90% yield and 98% enantiomeric excess (ee). Based on experimental observations a probable mechanism was proposed for this reaction. The current methodology was extended to the synthesis of b-phenylalanine in good yield and very good enantioselectivity.

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Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare

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Alkenylglycine amino acids were assessed as potential candidates for hydrocarbon stapling and shown to be effective in stapling of the BID BH3 peptide.

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Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare

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Unrestricted: Pseudoephenamine is introduced as a versatile chiral auxiliary and an alternative to pseudoephedrine in asymmetric synthesis. It is free from regulatory restrictions and leads to remarkable stereocontrol in alkylation reactions, especially in those that form quaternary carbon centers. Amides derived from pseudoephenamine exhibit a high propensity to be crystalline substances, and provide sharp, well-defined signals in NMR spectra. Copyright

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Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare

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The oxidation of alcohols to carbonyl compounds using air as the terminal oxidant is highly desirable. As described in previous reports, the abstraction of alpha-H of the alcohol is the most important step, and it typically requires not only a metal catalyst but also complex ligands, co-catalysts and bases. Herein, we report a practical and efficient method for the oxidation of primary alcohols, secondary alcohols, 1,2-diols, 1,2-amino alcohols, and other alpha-functionalized alcohols using a commercially available catalyst, Mn2(CO)10, and no additives. Preliminary mechanistic studies indicated that an alkoxyl radical intermediate existed in our system, and a plausible mechanism consistent with the experimental results and literature was proposed.

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Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare

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(+/-)-anti Head-to-head umbelliferone dimer was resolved into a pair of optically active forms in good yields with high optical purity by a diastereomeric seperation of two diastereomeric diamides obtained by the ring-opening addition reaction with optically pure erythro-2-amino-1,2-diphenylethanol or norephedrine, followed by hydrolysis and relactonization.The absolute configuration of the cyclobutane in (-)589-anti head-to-head umbelliferone dimer was confirmed to be (S,S,S,S) by an X-ray crystallographic analysis of the diamide derived from the (-)589-form by the ring-opening addition reaction with (S)-(-)589-1-(1-naphthyl)ethylamine.The absolute configuration of the cyclobutane in (-)589-anti head-to-head umbelliferone dimer is in agreement with that in (-)589-anti head-to-head coumarin dimer.

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Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare

Discovery of (1R,2S)-(−)-2-Amino-1,2-diphenylethanol

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In an article, published in an article, once mentioned the application of 23190-16-1, Name is (1R,2S)-(−)-2-Amino-1,2-diphenylethanol,molecular formula is C6H5CH(NH2)CH(C6H5)OH, is a conventional compound. this article was the specific content is as follows.Application In Synthesis of (1R,2S)-(−)-2-Amino-1,2-diphenylethanol

Carbacephem beta-lactam antibiotics having structure (I) are disclosed, including stereoisomers, pharmaceutically acceptable salts, esters and prodrugs thereof, wherein Ar2, X, R1 and R2 are as defined herein. The compounds are useful for the treatment of bacterial infections, in particular those caused by methicillin-resistant Staphylococcus spp.

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Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare

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(matrix presented) Amino alcohol 4 (or its enantiomer) is prepared in two simple steps. Commercial (1R,2S)-2-amino-1,2-diphenylethanol is dialkylated with bis(2-bromoethyl) ether. Subsequent hydrogenation over 5% Rh on alumina in the presence of morpholine unexpectedly stops at the hexahydro derivative 4. Amino alcohol 4 promotes the enantioselective addition of diethylzinc to aldehydes at room temperature in up to 99% enantiomeric excess.

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Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare

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Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 23190-16-1, Name is (1R,2S)-(−)-2-Amino-1,2-diphenylethanol, Recommanded Product: 23190-16-1.

New chiral V(V) Schiff base complexes (S)-[VO(OMe)L] and (R)-[VO(OMe)L] were synthesized and characterized by microanalysis, infrared (IR), UV-Visible, Circular dichroism (CD) spectroscopy and single crystal X-ray studies. The interaction of these complexes with calf thymus (CT) DNA and bovine serum albumin (BSA) protein showed chiral expression DNA/protein binding strength. The influence of chirality was also observed in cytotoxicity assay of Hep 2 cells. (R)-[VO(OMe)L] enantiomer exhibited higher binding constant (5 ± 1 × 105 M-1) as compared to (S)-[VO(OMe)L] (8 ± 1 × 104 M-1). The fluorescence quenching, thermal melting and viscosity data suggest DNA surface and/or groove binding nature of the complexes and electrophoresis studies also showed greater activity for (R)-[VO(OMe)L] in cleaving DNA and protein as against (S)-[VO(OMe)L].

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Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare