Category: 542-58-5

HPLC of Formula: 542-58-5. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 2-Chloroethyl acetate, is researched, Molecular C4H7ClO2, CAS is 542-58-5, about Double ester prodrugs of FR900098 display enhanced in-vitro antimalarial activity. Author is Wiesner, Jochen; Ortmann, Regina; Jomaa, Hassan; Schlitzer, Martin.

Fosmidomycin and FR900098 are inhibitors of the 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR; IspC), a key enzyme of the mevalonate-independent isoprenoid biosynthesis pathway. The authors have determined the in-vitro antimalarial activity of two double ester prodrugs (I)and (II) in direct comparison with the unmodified FR900098 against intraerythrocytic forms of Plasmodium falciparum. Temporarily masking the polar properties of the phosphonate moiety of the DXR inhibitor FR900098 I enhanced not only its oral bioavailability but also the intrinsic activity of this series against the parasites.

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Quality Control of 2-Chloroethyl acetate. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 2-Chloroethyl acetate, is researched, Molecular C4H7ClO2, CAS is 542-58-5, about Reaction of 2-methyl-2-phenyl-1,3-dioxolane with trimethylchlorosilane.

The title reaction in a sealed ampul containing KU-2 in the H+ form 6 h at 150° gave ROCH2CH2Cl (R = Bz, Ac, PhCH2CO) and PhCMe2Cl in 17, 9, 8 and 8% yield, resp. Mechanisms for formation of these products were given.

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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 542-58-5, is researched, Molecular C4H7ClO2, about Silica-supported guanidinium chloride-acetyl chloride as an efficient deprotecting reagent for acetals, the main research direction is deprotection acetal guanidinium chloride acetyl chloride.Electric Literature of C4H7ClO2.

Acetals have been treated with acetyl chloride in the presence of catalytic amounts of silica-supported guanidinium chloride to produce the corresponding aldehydes and ketones in good yields under neutral conditions.

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Valero, Rosendo; Song, Lingchun; Gao, Jiali; Truhlar, Donald G. published an article about the compound: 2-Chloroethyl acetate( cas:542-58-5,SMILESS:CC(OCCCl)=O ).Formula: C4H7ClO2. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:542-58-5) through the article.

Diabatic models are widely employed for studying chem. reactivity in condensed phases and enzymes, but there has been little discussion of the pros and cons of various diabatic representations for this purpose. Here the authors discuss and contrast six different schemes for computing diabatic potentials for a charge rearrangement reaction.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Radiometric determination of the solubility of rubidium perchlorate by the nonisotopic-indicator method, published in 1959, which mentions a compound: 542-58-5, Name is 2-Chloroethyl acetate, Molecular C4H7ClO2, Application In Synthesis of 2-Chloroethyl acetate.

The solubility of RbClO4 in water and EtOH is determined by means of Cs134, which coprecipitates isomorphously with RbClO4. Solutions of RbCl containing, per ml., 0.2 γ of Cs+ and 5, 10, or 20 mg. of Rb+ were prepared, and to 1 ml. of each was added 2 ml. of a 10% aqueous HClO4 solution or a 10% solution of NaClO4 in 96% EtOH. After 1 hr. the precipitate were centrifuged off, and the activity of the centrifugate measured. A definite volume of centrifugate was added to the precipitate, and the mixture heated on a water bath to dissolve all or most of the precipitate, and the solution cooled. After 1 hr. the precipitate was separated and the amount of coprecipitated Cs determined The activity of the mother liquor was practically the same as before; this showed the isomorphous nature of the coprecipitation of Cs with RbClO4; however, the Cs was not completely precipitated, and this was allowed for in determining the solubility of RbClO4. The precipitate of RbClO4 obtained from solution containing Cs and Rb in the ratios 1:25,000, 1:50,000, and 1:100,000 were washed with H2O and EtOH until the wash liquor reached a constant activity, and then stirred with the solvent at 15° until saturation was reached. The solubility of RbClO4 in water is 4.35 ± 0.09 × 10-2M, and in EtOH 4.35 ± 0.06 × 10-3M.

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Category: chiral-catalyst. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2-Chloroethyl acetate, is researched, Molecular C4H7ClO2, CAS is 542-58-5, about Synthesis of complex halo esters from α-chloromethyl esters of carboxylic acids. Author is Pishnamazzade, B. F.; Gasanova, Sh. D..

cf. CA 63:5534e. AcOCH2Cl (I) (105 g.) and 233.7 g. ClCH2CH2OH heated 10 hrs. at 50-60° yielded 38% AcOCH2CH2Cl, and 34% CH2(OCH2CH2Cl)2. PrCO2CH2CH2Cl was prepared similarly. I (56 g.) and 200 g. HOCH(CH2Cl)2 gave 46% AcOCH(CH2Cl)2, b3 97-8°, n20D 1.4785, d20 1.3914, and 40% CH2[OCH(CH2Cl)2]2, b3 197-9°, n20D 1.4960, d20 1.3868. Similarly, 8.5 g. I and 25 g. MeCCl:CHCH2OH yielded 40% AcOCH2CH:CClMe, b4 64-5°, n20D 1.4700, d20 1.1517, and 30% CH2(OCH2CH:CClMe)2. Similarly was prepared CCl3CO2CH2CH:CClMe, b4 100-2°, n20D 1.4762, d20 1.4143.

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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Action of aluminum chloride on esters of polyatomic alcohols》. Authors are Dobryanskii, A. F.; Sivertsev, A. P..The article about the compound:2-Chloroethyl acetatecas:542-58-5,SMILESS:CC(OCCCl)=O).Recommanded Product: 2-Chloroethyl acetate. Through the article, more information about this compound (cas:542-58-5) is conveyed.

Reaction of AlCl3 with esters of polyat. alcs. leads to replacement of only part of the acyl groups by Cl; usually 1 acyl group is left and does not react with AlCl3. The following esters do not react with AlCl3: AcOCH2CH2Cl, BzOCH2CH2Cl, AcOCH2CHClCH2Cl, and AcOCH2C(CH2Cl)3. This is explainable by accumulation of neg. Cl atoms in such esters. In the course of the reaction AlCl3 is changed into ClAl(OAcyl)2. (CH2OAc)2 (60 g.) and AlCl3 (47.8 g.) 1 hr. at 150-60° gave 38.5 g. distillable oil, which on redistillation gave a fraction b. 142-8°, d2020 1.1295, identified as AcOCH2CH2Cl; the Al compound was best isolated by boiling 6 g. (CH2OAc)2 and 5 g. AlCl3 in 60 cc. CCl4 1 hr., followed by cooling and separation of the glassy layer, which was powdered in dry benzene and washed with Et2O; its analysis corresponded to C4H6O4AlCl. (CH2OBz)2 (20 g.) and 10.5 g. AlCl3 heated 1 hr. to 150-60° gave 108 g. oil, which on distillation gave a fraction b40 139-40°, d2020 1.1783, d420 1.1789, nD20 1.5283, identified as BzOCH2CH2Cl; heating 5.6 g. (CH2OBz)2 and 1.3 g. AlCl3 1 hr. at 150°, followed by cooling and separation of the crystals, gave the Al compound in pure state after washing as above, and its analysis corresponded to C14H10O4AlCl. Triacetin (219 g.), 44.5 g. AlCl3, and 323 g. CCl4 boiled 1 hr. gave 160 g. of oil which on distillation gave a fraction b20 125-30°, d2020 1.2018, d420 1.1996, nD20 1.4393, identified as diacetin chlorohydrin (diacetoxychloropropane); the AlCl3 under such conditions is transformed into C4H6O4AlCl, which was isolated by cooling a mixture of 10.8 g. triacetin and 6.6 g. AlCl3 which had been heated 1 hr. to 150°. Triacetin (108 g.) and 66.7 g. AlCl3 heated 1 hr. to 140-50° gave 104.4 g. oil, which on distillation gave a fraction b20 90-5°, b40 115-20°, d2020 1.2733, d420 1.2714, identified as 2,3-dichloropropyl acetate; refluxing 20 g. of this with 60 g. NaI and 300 cc. Me2CO, then heating in a sealed tube to 120°, gave the diiodide which with Zn gave 5.6 g. allyl acetate, b. 99-104°, d420 0.9941, nD20 1.4045. Pentaerythritol tetraacetate (I) (30.4 g.) and 7.3 g. AlCl3 heated 1 hr. at 160° gave 26.5 g. oil which on distillation gave a fraction b4.5 152-60°, d2020 1.2272, d420 1.225, nD20 1.4587, identified as pentaerythritol triacetate monochlorohydrin. I (30.4 g.) and 13.3 g. AlCl3 heated 1 hr. at 160° gave 26.7 g. oil which on distillation gave pentaerythritol diacetate dichlorohydrin, b6 146-8°, d2020 1.2620, d420 1.2600, nD20 1.4681. I (30.4 g.) and 26.7 g. AlCl3 heated 1 hr. to 150-60° gave pentaerythritol monoacetate trichlorohydrin, b8 126-7°, d2020 1.3111, d420 1.3057, nD20 1.4832. The Al salt which separated as a crust from the cooled mixture, after washing with Et2O analyzed well for C4H6O4AlCl.

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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Halogenation in reactive solvents. II. The addition of halogen and acetoxyl to ethylene》. Authors are Weber, Fred C.; Hennion, G. F.; Vogt, R. R..The article about the compound:2-Chloroethyl acetatecas:542-58-5,SMILESS:CC(OCCCl)=O).SDS of cas: 542-58-5. Through the article, more information about this compound (cas:542-58-5) is conveyed.

cf. C. A. 32, 7405.8. ClCH2CH2OAc (I) and C2H4Cl2 (II) are the chief products when C2H4 is chlorinated in AcOH, Ac2O or AcOMe. In AcOH at 10-15° the mol. ratio of I/II is 0.522; addition of AcOH gives a ratio of 0.957; at 40-3° the ratio is 0.611. In Ac2O the ratio at room temperature is 0.195; with addition of AcONa, 0.770; in the 1st case AcCl is formed. In AcOMe the ratio is 0.476; AcOC2H2Cl3 and MeCl are also formed.

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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called New polymer protecting group in oligonucleotide synthesis. 2-Hydroxyethyl phenyl thio ether of polyethylene glycol, published in 1974, which mentions a compound: 542-58-5, mainly applied to thymidine protection polyethylene glycol, Related Products of 542-58-5.

Bis[4-(2-hydroxyethylthio)phenylamino]polyethylene glycol condensed with the thymidine nucleotide I to give ∼90% of the corresponding phosphate-protected nucleotide. The protecting group was cleaved by sequential N-chlorosuccinimide oxidation and treatment with NaOH.

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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 542-58-5, is researched, Molecular C4H7ClO2, about Effect of branching on the thermal properties of novel branched poly(4-ethyleneoxy benzoate), the main research direction is hydroxyethoxybenzoate polyester preparation branching thermal property.Formula: C4H7ClO2.

Poly(4-ethyleneoxy benzoate) (PEOB) was synthesized by the self-condensation of Et 4-(2-hydroxyethoxy)benzoate (E4HEB) under transesterification conditions. Branched PEOB was prepared by the condensation of E4HEB with an AB2 monomer, Et 3,5-bis(2-hydroxyethoxy)benzoate (EBHEB), under similar conditions. Varying amounts of branching (0-50%) were introduced into the linear polymer by changes in the composition of the comonomers in the feed. The solution viscosity of the polymers indicated that they had reasonable mol. weights; the extent of branching in these copolymers was established from their 1H NMR spectra. Differential scanning calorimetry studies indicated that, as expected, the introduction of branching drastically affected the percent crystallinity of the copolymers (as seen from their ΔHm, the enthalpy of melting), and when the extent of the incorporation of the AB2 monomer exceeded 10 mol%, the copolymers were completely amorphous. The melting temperatures of the copolymers decreased with an increase in the branching content, whereas the peak crystallization temperature in quenched (amorphous) samples followed the exactly opposite trend. The glass-transition temperatures (Tg) of the branched copolymers first decreased at low extents of branching, passed through a min., and then increased to attain the Tg of the pure hyperbranched polymer of EBHEB.

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