Category: 602-09-5

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.602-09-5,[1,1′-Binaphthalene]-2,2′-diol,as a common compound, the synthetic route is as follows.

Add 22.88 g (80 mmol) of binaphthol to 100 mL of acetic acid and 100 mL of CH 2 Cl 2 solution, and add 6.8 mL (160.4 mmol) of fuming HNO3 in an ice bath, and stir at room temperature overnight.TLC detects the formation of new substances and pours the product into ice water for filtration.The solid was washed with CH 2 Cl 2 and methanol.TLC is detected as a point, vacuum dried,The product a6,6′-dinitro(1,1′-binaphthyl-2,2′) diol was obtained., 602-09-5

As the paragraph descriping shows that 602-09-5 is playing an increasingly important role.

Reference£º
Patent; East China Normal University; Liu Qiancai; Ma Junyi; Tao Xuewei; An Shujie; Tang Guofeng; (12 pag.)CN109810124; (2019); A;,
Chiral Catalysts
Chiral catalysts – SlideShare

As a common heterocyclic compound, it belong chiral-catalyst compound,[1,1′-Binaphthalene]-2,2′-diol,602-09-5,Molecular formula: C20H14O2,mainly used in chemical industry, its synthesis route is as follows.,602-09-5

The reaction was carried out in an ice bath. Tetrahydrofuran (30 mL) was added to a solution of sodium hydride (1.92 g, 80 mmol)Three-necked flask. A solution of 1,1′-binaphthol (compound (1)) (10 g, 34 mmol) in tetrahydrofuran (50 mL) was dissolvedThe solution was slowly added dropwise to the reaction solution over a period of 20 minutes. After completion of the addition, the reaction was continued for 30 minutes, and then chloromethyl ether (6.4 g, 80 mmol) was slowly added dropwise to the reaction solution. The reaction was continued for about one hour and monitored by thin layer chromatography. After the reaction was complete, the reaction was quenched with water (20 mL). The organic material was extracted with dichloromethane and water and the solvent was removed. The compound (2) was isolated by column chromatography on silica gel using a mixture of petroleum ether and ethyl acetate (5: 1) as the eluent. Yield: 90%.

With the synthetic route has been constantly updated, we look forward to future research findings about [1,1′-Binaphthalene]-2,2′-diol,belong chiral-catalyst compound

Reference£º
Patent; East China University of Science and Technology; LILIES GROUP CO., LTD; Wang, Limin; Wu, Shengming; Zhang, Kewei; Wang, Feng; Wang, Guifeng; Tian, He; Wang, Zhenyan; Chen, Lirong; Huang, Zhuo; (23 pag.)CN104478915; (2016); B;,
Chiral Catalysts
Chiral catalysts – SlideShare

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.602-09-5,[1,1′-Binaphthalene]-2,2′-diol,as a common compound, the synthetic route is as follows.

602-09-5, (¡À)-BINOL (24.9 g, 86.9 mmol), 1-bromobutane (25.0 g, 182.5 mmol), potassium carbonate (36.0 g, 260.7 mmol) was added to a solution of DMAc (250 mL), and the mixture was stirred at 90 C. for 10 hours for reaction. Further, potassium carbonate (15.0 g, 108.5 mmol), 1-Bromobutane (11.5 g, 83.9 mmol) was added, the mixture was stirred at the same temperature for 12 hours and reacted. After cooling to room temperature, toluene and ion exchanged water were added, the organic layer was washed twice with ion exchanged water, and the solvent was distilled off under reduced pressure. Methanol was added to the concentrate, the solid content was dispersed, filtered, dried under reduced pressure at 40 C., Intermediate 172A (32.1 g, 92.7%) was obtained as a cream colored solid.

As the paragraph descriping shows that 602-09-5 is playing an increasingly important role.

Reference£º
Patent; ADEKA CORPORATION; YANAGISAWA, SATOSHI; MIHARA, TAIKI; MIYAKE, JUNYA; (60 pag.)JP2017/149661; (2017); A;,
Chiral Catalysts
Chiral catalysts – SlideShare

Name is [1,1′-Binaphthalene]-2,2′-diol, as a common heterocyclic compound, it belongs to chiral-catalyst compound, and cas is 602-09-5, its synthesis route is as follows.,602-09-5

5.73 g (20 mmol) of (1,1?-binaphthalene)-2,2?-diol and 4.10 g (20 mmol) of p-TsOH were dissolved in 150 mL of toluene, and then stirred at about 100 C. for about 12 hours. The resulting product was cooled down to room temperature, and an aqueous potassium carbonate solution was added thereto, followed by extraction three times with 60 mL of ethyl acetate. An organic layer was collected from the resulting product and dried using magnesium sulfate. After evaporating the solvent from the resulting product, the residue was separated and purified using silica gel column chromatography to obtain 3.76 g (Yield: 70%) of Intermediate I-1. This compound was identified using liquid chromatography-mass spectrometry (LC-MS). (0315) C20H12O: M+1 268.3

With the complex challenges of chemical substances, we look forward to future research findings about [1,1′-Binaphthalene]-2,2′-diol

Reference£º
Patent; SAMSUNG DISPLAY CO., LTD.; Park, Junha; Kim, Youngkook; Sim, Munki; Lee, Eunyoung; Jeong, Eunjae; Hwang, Seokhwan; Kim, Donghyun; (122 pag.)US2016/285011; (2016); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare

602-09-5, [1,1′-Binaphthalene]-2,2′-diol is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

602-09-5, In a glass reactor equipped with a stirrer, a condenser, and a thermometer,180 g (0.629 mol) of (RS) -1,1′-bi-2-naphthol, 127 g (1.439 mol) of ethylene carbonate, 9.0 g of potassium carbonate and 180 g of toluene were charged and stirred at 110 C. for 10 hours. After 1300 g of toluene was added to the reaction product, the organic layer was washed with an aqueous solution of sodium hydroxide while maintaining the temperature at 80 C. Next, this organic layer was washed with water until the washing water became neutral. The obtained organic layer was dehydrated under reflux using a Dean Stark apparatus to obtain a toluene solution in which (RS) -2,2′-bis (2-hydroxyethoxy) -1,1′-binaphthalene was dissolved. Thereafter, when the solution was cooled, crystals precipitated at 63 C. all at once, making it difficult to stir, 1200 g of toluene was added to make it into a slurry state containing crystals and allowed to stir, and then cooled further to 30 C. This was filtered and the crystals were further washed with 200 g of toluene, and the obtained crystals were dried to obtain 198 g of pale yellow crystals of (RS) -2,2′-bis (2-hydroxyethoxy) -1,1′-binaphthalene The yield was 84.1%, the HPLC purity was 99.1%, the total content of organic substances having a boiling point of 250 C. or lower at 101.3 kPa: 0.1%). Differential scanning calorimetry and powder X-ray diffraction measurement were performed on the obtained crystals. The differential scanning calorimetry chart and the powder X-ray diffraction pattern of the obtained crystal are shown in FIGS. 1 and 2, respectively

602-09-5 [1,1′-Binaphthalene]-2,2′-diol 762831, achiral-catalyst compound, is more and more widely used in various fields.

Reference£º
Patent; TAOKA CHEMICAL COMPANY LIMITED; MATSUURA, TAKASHI; HIRABAYASHI, SHUNICHI; (8 pag.)JP2016/204293; (2016); A;,
Chiral Catalysts
Chiral catalysts – SlideShare

As a common heterocyclic compound, it belongs to chiral-catalyst compound, name is [1,1′-Binaphthalene]-2,2′-diol, and cas is 602-09-5, its synthesis route is as follows.,602-09-5

In a glass reactor equipped with a stirrer, a condenser, and a thermometer,180 g (0.629 mol) of (RS) -1,1′-bi-2-naphthol,127 g (1.439 mol) of ethylene carbonate,9.0 g of potassium carbonate and 180 g of toluene,And reacted at 110 C. for 10 hours. As a result of HPLC measurement,0.1% of 1,1′-bi-2-naphthol,89.4% of 2,2′-bis (2-hydroxyethoxy) -1,1′-binaphthalene,The polymer was 6.9%, the others were 1 mol adduct and 3 mol adduct.620 g of toluene was added to this reaction mixture and diluted,270 g of a 9.7 wt% sodium hydroxide aqueous solution was added to the organic solvent phase containing the reaction mixture, and the mixture was stirred at 85 C. for 1 hour, and then the aqueous phase was separated off and removed.As a result of measuring the organic solvent layer by HPLC,It was 96.2% of 2,2′-bis (2-hydroxyethoxy) -1,1′-binaphthalene, and no polymer was detected.Next, this organic solvent layer was washed with water until the washing water became neutral.After refluxing and dehydrating the obtained organic solvent phase, it was cooled to room temperature, filtered and dried to obtain (RS) -2,2′-bis (2-hydroxyethoxy) -1,1′-binaphthalene as white crystals (Yield 83.6%, HPLC purity 99.6%, YI value: 2.9).

With the complex challenges of chemical substances, we look forward to future research findings about 602-09-5,belong chiral-catalyst compound

Reference£º
Patent; TAOKA CHEMICAL COMPANY LIMITED; MATSUURA, TAKASHI; KAWAMURA, MIO; HIRABAYASHI, SHUNICHI; FUJII, KATSUHIRO; (11 pag.)JP6083901; (2017); B2;,
Chiral Catalysts
Chiral catalysts – SlideShare

[1,1′-Binaphthalene]-2,2′-diol, cas is 602-09-5, it is a common heterocyclic compound, the chiral-catalyst compound, its synthesis route is as follows.,602-09-5

In a 3000 mL four-necked flask, 343.2 g (1.2 mol) of (¡À)-1,1′-bi(2-naphthol), 600 g of toluene, 48 g of N,N-dimethylacetamide, 22.8 g of potassium carbonate and 704 g (3 mol) of ethylene carbonate. After 6 hours of reaction at 100 C, The content of (¡À) -2,2′-bis- (2-hydroxyethoxy) -1,1′-binaphthalene was less than 0.1% by HPLC analysis, and the reaction was stopped. Toluene was added, washed with water to neutrality, and the solid was precipitated by cooling, and put into a 1000 mL oven with spiral stirring. Toluene was added, washed with water to neutrality, and the solid was precipitated by cooling, and put into a 1000 mL oven with spiral stirring. Grinding the dried under vacuum, drying temperature 85 , drying time of 18 hours, to give (¡À) -2,2′- two – (2-hydroxyethoxy) -1,1′-binaphthyl 391.73g, yield 87.19%.

With the rapid development of chemical substances, we look forward to future research findings about [1,1′-Binaphthalene]-2,2′-diol

Reference£º
Patent; Jiangsu Yong Xing Chemical Co., Ltd.; Xu Weihua; Zhao Jinlong; Lu Guoyuan; Zhang Qiang; (15 pag.)CN110483259; (2019); A;,
Chiral Catalysts
Chiral catalysts – SlideShare

602-09-5, [1,1′-Binaphthalene]-2,2′-diol is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

602-09-5, In a round-bottom flask, 1,10 -binaphthol (3.49 mmol) were dissolvedin acetic acid (15 mL). After kept in the ice-water bath for 15 min, nitricacid (98%, 0.62 mL) was dropped into the solution slowly under a strongmagnetic stirring. Then, the ice water bath was removed and the solutionwas stirred at room temperature for 1 h. While, the clear mixture became white, turned to black and finally was green. The mixture was poured into ice-water (500 mL) and stirred for 10 min. The powder (compound 1) was collected from the ice-water using the vacuum filtration and was washed with cold ethanol till its color became grayish yellow. The yield of compound 1 is 78%. Mp > 300 C. 1H NMR(DMSO-d6, 400 MHz, delta, ppm): 10.34 (s, 2H), 8.96 (d, J 1.5 Hz, 2H),8.28 (dd, J 1.5, 7.2 Hz, 2H), 7.97 (d, J 7.2 Hz, 2H), 7.53 (d,J 9.0 Hz, 2H), 7.09 (d, J 9.0 Hz, 2H); 13C NMR (DMSO-d6, 75 MHz):delta 157.1, 142.4, 137.0, 132.1, 126.3, 125.5, 125.2, 120.6, 119.6, 115.0

602-09-5 [1,1′-Binaphthalene]-2,2′-diol 762831, achiral-catalyst compound, is more and more widely used in various fields.

Reference£º
Article; Deng, Guoxiong; Wang, Yilei; Zong, Xueping; Yuan, Xiaoxu; Luo, Jiangzhou; Wang, Xuezhen; Xue, Song; Polymer; vol. 183; (2019);,
Chiral Catalysts
Chiral catalysts – SlideShare

[1,1′-Binaphthalene]-2,2′-diol, cas is 602-09-5, it is a common heterocyclic compound, the chiral-catalyst compound, its synthesis route is as follows.,602-09-5

To 18.3 g of sodium hydride was added 50 g (0.175 mol) of 2,2′-dihydroxy-1,1′-dinaphthyl and stirred under nitrogen in 1.0 L of dry tetrahydrofuran (THF). After 1 hour, 116 g of chloromethyl methyl ether was added to the heavy precipitate and the resulting mixture was stirred for about 12 hours and then filtered through a pad of celite. The filtrate was shaken with 500 ml of water and 1 L of methylene chloride. An aqueous layer formed and was extracted two times more with methylene chloride. The combined organic layers were washed with water saturated with potassium bicarbonate. The organic layer was dried and filtered through a squat column of alumina and the column filtrate was evaporated until crystals appeared. The crude product was purified on a silica gel column by elution with a methylene chloride/hexane solution. About 53.5 g (63%) of 2,2′-bis(methoxymethoxy)-1,1′-dinaphthyl, m.p 93-94 C., 0.11 mol was collected. [00053] Next, 171 ml of 1.6 N butyllithium in hexane was added to a mixture of 41 g of the above bisacetal in 1 L of tetrahydrofuran and stirred under nitrogen at 0 C. for 45 minutes. The reaction mixture was then allowed to warm to 25 C. and 25.8 ml of dimethyl sulfate was added to the suspension and the mixture was stirred for 12 hours. About 30 ml of water saturated with sodium carbonate was added and the solvent was evaporated under reduced pressure at 50 C. [00054] The residue, in 300 ml of methylene chloride, was washed twice with water. An additional 300 ml of methylene chloride, 300 ml of methanol, and 25 ml of concentrated hydrochloric acid was added to the organic solution. The solution was stirred for 3 hours, and the solvent was evaporated. The yellow product was recrystallized from methylene chloride-hexane and was purified on a silica gel column (methylene chloride, hexane 1:1) to give 29.5 g (86%) of (R)-3-3′-dimethyl-2,2′-dihydroxy-1,1′-dinaphthyl, m.p. 204-206 C.; 1HNMR:2.2(s.6H), 7.1(d.2H), 7.3(m.2H), 7.4(m.2H), 7.8(m.4H).

As the rapid development of chemical substances, we look forward to future research findings about 602-09-5

Reference£º
Patent; IBC Advanced Technologies, Inc.; US6686479; (2004); B2;,
Chiral Catalysts
Chiral catalysts – SlideShare

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.602-09-5,[1,1′-Binaphthalene]-2,2′-diol,as a common compound, the synthetic route is as follows.

602-09-5, [ 1 , 1 ,-Binaphthalene]-2,2′-diol (30.0 g, 0. 1 05 mo I, 1 .0 eq. ) was placed in a flask and flushed with argon. Anhydrous toluene (300 m L ) was added, followed by trifluoromethanesulfonic acid (1 1.7 ml., 0.2 1 0 mo I, 2.0 eq. ). After further degassing, the mixture was re fluxed for 48 hours. After cool ing, the organic layer was extracted with water (500 m l. ), dried over gSO i, and reduced under vacuum until precipitation. Hexane (300 ml.) was then added, and the resulting suspension was stirred for 2h before being filtered off. This solid was dissolved in DC I, and filtered over silica (elution with hexane / DCM 2 : 1 ). The volume of the fraction obtained was reduced to ca. 50 m l., and the resulting crystals were filtered off, yielding the title compound.

The synthetic route of 602-09-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NOVALED GMBH; DENKER, Urlich; ZOeLLNER, Mike; GRAeF, Katja; SENKOVSKYY, Volodymyr; WALLIKEWITZ, Bodo; SCHOLZ, Johannes; FREY, Julien; (143 pag.)WO2016/180891; (2016); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare