Category: chiral-catalyst

It is a common heterocyclic compound, the chiral-catalyst compound, (S)-(1-Ethylpyrrolidin-2-yl)methanamine, cas is 22795-99-9 its synthesis route is as follows.,22795-99-9

0.414 g (1 mmol) of compound 4a prepared in Preparation 9 was dissolved in 10 ml of anhydrous toluene, 0.39 ml of thionyl chloride was added, and the mixture was heated at 60 ¡ã C. under argon for 1 hour and then evaporated to dryness. 10 ml of anhydrous DCM was added,(S) -2-aminomethyl-1-ethylpyrrole 0.154g under ice-water bath, the reaction was stirred at room temperature for 8 hours, diluted with 50ml of EtOAc,Washed with saturated aqueous solution of NaHCO3, saturated NaCl three times, the organic layer was dried over Na2SO4, filtered and evaporated to give a yellowish oil,The residue was separated by a medium pressure silica gel column and the mobile phase petroleum ether: ethyl acetate 1: 1 (2percent TEA (triethylamine)). The product fractions were collected and evaporated to give 0.396 g as a yellowish oil, yield 75.6percent.

With the complex challenges of chemical substances, we look forward to future research findings about (S)-(1-Ethylpyrrolidin-2-yl)methanamine

Reference£º
Patent; Beijing Nerve Surgical Department Institute; Liu Qian; Zhang Yazhuo; Yang Xiaoxiao; CN106366075; (2017); A;,
Chiral Catalysts
Chiral catalysts – SlideShare

Name is D-Phenylalanine, as a common heterocyclic compound, it belongs to chiral-catalyst compound, and cas is 673-06-3, its synthesis route is as follows.,673-06-3

Step A. Preparation of Nalpha-(4-methylbenzenesulfonyl)-D-phenylalanine D-phenylalanine was reacted with 4-methylbenzenesulfonyl chloride under the conditions used in general procedure A giving the title compound which was recrystallized from ether (18%). LC-MS: 318 (M-H)-, 98% pure.

With the complex challenges of chemical substances, we look forward to future research findings about D-Phenylalanine

Reference£º
Patent; Stranix, Brent Richard; Sauve, Gilles; Bouzide, Abderrahim; Cote, Alexandre; Berube, Gervais; Soucy, Patrick; Zhao, Yongsen; Yelle, Jocelyn; US2002/151546; (2002); A1;,
Chiral Catalysts
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As a common heterocyclic compound, it belong chiral-catalyst compound,trans-Cyclohexane-1,2-diamine,1121-22-8,Molecular formula: C6H14N2,mainly used in chemical industry, its synthesis route is as follows.,1121-22-8

[0395] The ligand was prepared using the method described by Gao. H-X; Zhang, H.; Yi, X-D; Xu, P.-P.; Tang, C.-L.; Wan, H.-L.; Tsai, K.-R.; Ikariya, T.; (Chirality 2000, 12, 383-388). [0396] 12.65 g of anhydrous magnesium sulphate (105.1 mmoles) and 4.2 ml of a racemic trans-1,2-diaminocyclohexane mixture (35.0 mmoles) were successively added to a solution of 6.66 ml of 2-pyridylaldehyde (70.0 mmoles) in 50 ml of absolute ethanol. [0397] The reaction mixture was stirred for 20 hours at ambient temperature (the solution turned yellow after stirring for three hours), heated for 2.5 hours under reflux, then filtered through a frit. [0398] The isolated solid was washed with dichloromethane. [0399] The total filtrate was concentrated completely under reduced pressure to isolate an ochre solid, which was re-crystallised from ethanol. [0400] 8.2 g of pale yellow crystals were obtained, which corresponded to a 80.1% yield. [0401] The characteristics were as follows: [0402] M.Pt: 140-141 C. (EtOH) (racemic mixture) (Lit: 127-129 C.: obtained by Belokon, Y N; North, M: Churkina, T D; Ikonnikov, N S; Maleev, V I; Tetrahedron 2001, 57, 2491-2498 for the stereoisomer 1S,2S, hexane-MeOH); [0403] 1H NMR/CDCl3: delta 8.51 (m, 2H, H1,2), 8.28 (s, 2H, H7,14), 7.84 (m, 2H, H4,17), 6.55-7.64 (m, 2H, H5,16), 7.14-7.21 (m, 2H, H3,18), 3.50 (m, 2H, H8, 13), 1,81 (m, 6H, H10,11 and H carried by carbons 9 and 12 located in the position cis (or trans) with respect to the adjacent nitrogen atoms), 1.40-1.53 (m, 2H, H carried by carbons 9 and 12 located in the trans (or cis) position with respect to the adjacent nitrogen atoms). [0404] 13C NMR/CDCl3: delta 161.42 (C7 and C14), 154.61 (C6 to C15), 149.21 (C1 and C2), 136.39 (C4 and C17), 124.43 (C3 and C18), 121.29 (C5 and C16), 73.53 (C8 and C13), 32.70 (C9 and C12), 24.33 (C10 and C11). [0405] FAB+ (NBA matrix): 293 (100%, M+1), 107 (52%, 2-pyridylaldimine+H+), 92 (38%, C5H4N-CH2+), 119 (25%, C5H4N-CHN-CH2+), 294 (23%, M+2), 204 (22%, [M-(2-pyridylidene)]+), 79 (21%, pyridine+), 187 (20%, M-[2-pyridylineamino]+), 585 (1%, 2M+1).

With the synthetic route has been constantly updated, we look forward to future research findings about trans-Cyclohexane-1,2-diamine,belong chiral-catalyst compound

Reference£º
Patent; Cellier, Pascal Philippe; Cristau, Henri-Jean; Spindler, Jean-Francis; Taillefer, Marc; US2003/236413; (2003); A1;,
Chiral Catalysts
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As a common heterocyclic compound, it belongs to quinuclidine compound,Quinuclidine-4-carboxylic acid hydrochloride,40117-63-3,Molecular formula: C8H14ClNO112,mainly used in chemical industry, its synthesis route is as follows.,1121-22-8

General procedure: To a mortar were added 3,5-di-tert-butyl-2-hydroxybenzaldehyde (0.468 g, 2 mmol) and trans-cyclohexane-1,2-diamine (0.114 g,0.123 mL, 1 mmol), and these were mixed over 10 min. The product was recrystallized (CH2Cl2/EtOH 1:9) to give 1a as a bright yellow solid; yield: 0.487 g (89%).

With the complex challenges of chemical substances, we look forward to future research findings about trans-Cyclohexane-1,2-diamine,belong chiral-catalyst compound

Reference£º
Article; Civicos, Jose F.; Coimbra, Juliana S. M.; Costa, Paulo R. R.; Synthesis; vol. 49; 17; (2017); p. 3998 – 4006;,
Chiral Catalysts
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673-06-3, D-Phenylalanine is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred solution of D-Phenylalanine (15 g, 90.80 mmol, 1 equiv.) in 5% aqueous NaHCO3 (800 mL)at room temperature was added benzyl chloroformate (15.34 mL, 108.97 mmol, 1.2 equiv.) and resultingmixture was allowed to stir for 12 h. Diethyl ether (200 mL) was added to remove the excess of benzylchloroformate. Aqueous layer was acidified with 6 N hydrochloric acid to pH 1 and extracted with ethylacetate (300 mL ¡Á 3). Combined organic layers were dried with anhydrous MgSO4, filtered andconcentrated under reduced pressure to give compound 11 (27 g) as a white solid in quantitative yield.The product was directly used for next step without any further purification., 673-06-3

The synthetic route of 673-06-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Wan, Yang; Stanovych, Andrii; Gori, Didier; Zirah, Severine; Kouklovsky, Cyrille; Alezra, Valerie; European Journal of Medicinal Chemistry; vol. 149; (2018); p. 122 – 128;,
Chiral Catalysts
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(1R,2S)-2-Amino-1,2-diphenylethanol, cas is 23190-16-1, it is a common heterocyclic compound, the chiral-catalyst compound, its synthesis route is as follows.,23190-16-1

Step 1: A mixture of (li?,2S)-2-amino-l,2-diphenylethanol (4.28 g, 20.0 mmol), K2CO3 (0.28 g 2.03 mmol) and diethyl carbonate (20 mL, 166 mmol) was heated under reflux for 16 hrs. The resulting mixture was washed with water (10 mL) and extracted with CH2Cl2 (300 mL). The organic phase was dried MgSO4, filtered and concentrated. The residue was recrystallized form toluene to give the desired compound (4S,5i?)-4,5-diphenyloxazolidin-2-one as white solid. Yield 88%, ESI-MS: 240.1 [M+]

With the synthetic route has been constantly updated, we look forward to future research findings about (1R,2S)-2-Amino-1,2-diphenylethanol,belong chiral-catalyst compound

Reference£º
Patent; ACHAOGEN, INC.; MOSER, Heinz, E.; WAGMAN, Allan, S.; WO2010/123997; (2010); A1;,
Chiral Catalysts
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.602-09-5,[1,1′-Binaphthalene]-2,2′-diol,as a common compound, the synthetic route is as follows.

Add 22.88 g (80 mmol) of binaphthol to 100 mL of acetic acid and 100 mL of CH 2 Cl 2 solution, and add 6.8 mL (160.4 mmol) of fuming HNO3 in an ice bath, and stir at room temperature overnight.TLC detects the formation of new substances and pours the product into ice water for filtration.The solid was washed with CH 2 Cl 2 and methanol.TLC is detected as a point, vacuum dried,The product a6,6′-dinitro(1,1′-binaphthyl-2,2′) diol was obtained., 602-09-5

As the paragraph descriping shows that 602-09-5 is playing an increasingly important role.

Reference£º
Patent; East China Normal University; Liu Qiancai; Ma Junyi; Tao Xuewei; An Shujie; Tang Guofeng; (12 pag.)CN109810124; (2019); A;,
Chiral Catalysts
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Name is 1,4,7,10,13-Pentaoxacyclopentadecane, as a common heterocyclic compound, it belongs to chiral-catalyst compound, and cas is 33100-27-5, its synthesis route is as follows.,33100-27-5

General procedure: Crystals of compounds 1?3 were prepared by isothermal evaporation fromaqueous solutions at room temperature. The crystals of compound 1 weresynthesized by the reaction of 0.051 g (0.1 mmol) of UO2(NO3)2¡¤6H2O,0.040 g (0.22 mmol) of 12-crown-4, 0.280 g (2.0 mmol) of 40percent H2SeO4,and 2.001 g (111.2 mmol) of deionized distilled water. Compound 2:0.050 g (0.1 mmol) of uranyl nitrate, 0.046 g (0.21 mmol) of 15-crown-5,0.282 g (2.0 mmol) of selenic acid, and 2.012 g (111.7 mmol) of deionizeddistilled water. Compound 3: 0.050 g (0.1 mmol) of uranyl nitrate, 0.046 g(0.21 mmol) of 15-crown-5, 0.282 g (2.0 mmol) of selenic acid, and 2.012 g(111.7 mmol) of deionized distilled water (note: the bulk of crystals herebelongs to compound 2). Homogeneous liquid solutions were left in awatch glass. Yellowish-green flattened crystals formed within 2 weeks.

With the complex challenges of chemical substances, we look forward to future research findings about 1,4,7,10,13-Pentaoxacyclopentadecane

Reference£º
Article; Gurzhiy, Vladislav V.; Tyumentseva, Olga S.; Tyshchenko, Darya V.; Krivovichev, Sergey V.; Tananaev, Ivan G.; Mendeleev Communications; vol. 26; 4; (2016); p. 309 – 311;,
Chiral Catalysts
Chiral catalysts – SlideShare

D-Phenylalanine, cas is 673-06-3, it is a common heterocyclic compound, the chiral-catalyst compound, its synthesis route is as follows.,673-06-3

The 10mmolD-phenylalanie dissolved in 50 ml tetrahydrofuran, ice water bath to 0 C left and right, add triethylamine 20mmol. Then the 15mmol (Boc)2O into to the above-mentioned solution. 0 C left and right, reaction 60 min, then room temperature reaction 15h, after the reaction. The reaction solution with ethyl acetate extraction 2-3 time, remove the upper layer, pH is adjusted with acid, then dichloromethane is used for extraction 2-3 time. Merging the lower organic phase, dried with anhydrous sodium sulfate, concentrated solvent, get intermediate 1

With the synthetic route has been constantly updated, we look forward to future research findings about D-Phenylalanine,belong chiral-catalyst compound

Reference£º
Patent; Zunyi Medical College; Yang, Jiaqiang; Yang, Juan; Ceng, Fakui; Li, Peng; (9 pag.)CN105503947; (2016); A;,
Chiral Catalysts
Chiral catalysts – SlideShare

As a common heterocyclic compound, it belongs to quinuclidine compound,Quinuclidine-4-carboxylic acid hydrochloride,40117-63-3,Molecular formula: C8H14ClNO52,mainly used in chemical industry, its synthesis route is as follows.,673-06-3

The reaction of bromobenzene (0.158 g, 1.0mmol), D-phenylalanine (0.247 g, 1.5 mmol), copper powder (0.0064 g, 0.1 mmol),MI (0.036 g, 0.2 mmol), Cs2CO3 (0.977 g, 3.0 mmol), TBAHS (0.068 g, 0.2 mmol)produced 0.200 g (83%) of phenyl-D-phenylalanine as a white solid.

With the synthetic route has been constantly updated, we look forward to future research findings about D-Phenylalanine,belong chiral-catalyst compound

Reference£º
Article; Zhou, Qifan; Du, Fangyu; Chen, Yuanguang; Fu, Yang; Chen, Guoliang; Tetrahedron Letters; vol. 60; 29; (2019); p. 1938 – 1941;,
Chiral Catalysts
Chiral catalysts – SlideShare