Category: chiral-catalyst

22795-99-9, (S)-(1-Ethylpyrrolidin-2-yl)methanamine is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a well-stirred solution of 83 4-chloroaniline (a2) (0.57g, 4.5mmol) and 84 NEt3 (5mL) in dry 28 DCM (25mL) was added dropwise a solution of compound 26 10 (0.51g, 2.0mmol) at room temperature. The reaction mixture was stirred at room temperature for 14h. The crude mixture was obtained by removal of the organic solvents under reduced pressure and was re-dissolved in DCM, followed by washing with H2O for 3 times. The organic layers were combined, dried over anhydrous MgSO4, filtered and concentrated in vacuum. Purification of the product was performed by flash column chromatography on silica gel to afford the desired 85 compound 11_a2 (0.28g) in 45percent yield., 22795-99-9

The synthetic route of 22795-99-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Jin, Wen Bin; Xu, Chen; Cheng, Qipeng; Qi, Xiao Lin; Gao, Wei; Zheng, Zhiwei; Chan, Edward W.C.; Leung, Yun-Chung; Chan, Tak Hang; Wong, Kwok-Yin; Chen, Sheng; Chan, Kin-Fai; European Journal of Medicinal Chemistry; vol. 155; (2018); p. 285 – 302;,
Chiral Catalysts
Chiral catalysts – SlideShare

94-91-7, N,N’-Bis(salicylidene)-1,2-propanediamine is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,94-91-7

General procedure: Uranyl acetate dehydrate (1 mmol) and synthesized Schiff base (1 mmol) (1:1 ratio) were mixed in methanol (25 ml). The mixture was refluxed for 3 h and then allowed to cool to room temperature. An orange (red) precipitate was filtered off, washed with methanol, and dried at room temperature (Scheme 1).

94-91-7 N,N’-Bis(salicylidene)-1,2-propanediamine 7210, achiral-catalyst compound, is more and more widely used in various fields.

Reference£º
Article; Asadi, Zahra; Shorkaei, Mohammad Ranjkesh; Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy; vol. 105; (2013); p. 344 – 351;,
Chiral Catalysts
Chiral catalysts – SlideShare

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.22795-99-9,(S)-(1-Ethylpyrrolidin-2-yl)methanamine,as a common compound, the synthetic route is as follows.

First, 4-benzyloxy-3,5-dimethoxybenzoic acid chloride represented by Formula 85 and [(2S)-1-ethylpyrrolidin-2-yl]methanamine represented by Formula 103 were prepared in 0.2 M solution, respectively, using a toluene solvent. An amine solution (1.2 mL, 0.240 mmol) entered 10 mL vial and a sodium carbonate solution (0.4 mL, 0.200 mmol) was added thereto. Thereafter, a benzoic acid chloride solution (1.0 mL, 0.200 mmol) entered the vial, vigorously shaken and agitated at room temperature for 18 hours. After terminating the reaction, an organic layer was moved to a cartridge tube (6 mL, benzenesulfonic acid, 904030-WJ, UCT) using ethyl acetate. Impurities were removed using methanol (15 mL) while separation and purification were conducted using an elute solution (ethyl acetate/methanol/triethylamine, 20:2:1, v/v/v), resulting in a benzamide compound represented by Formula 13 as a desired product (WZ-014; 66 mg, 83percent yield). [0114] Analysis data of the produced benzamide compound is provided as follows. 1H-NMR (MeOD-d4) d 1.22(t, 3H), 1.73(m, 1H), 1.80(m, 2H), 1.98(m, 1H), 2,30(m, 1H), 2.41(m, 1H), 2.76(m, 1H), 3.02(m, 1H), 3.28(m, 2H), 3.65(dd, 1H), 3.88(s, 6H), 5.02(s, 2H), 7.17?7.46(m, 7H)., 22795-99-9

22795-99-9 (S)-(1-Ethylpyrrolidin-2-yl)methanamine 643457, achiral-catalyst compound, is more and more widely used in various fields.

Reference£º
Patent; Vivozon Inc.; LEE, Doo Hyun; EP2786986; (2014); A2;,
Chiral Catalysts
Chiral catalysts – SlideShare

(S)-(1-Ethylpyrrolidin-2-yl)methanamine, cas is 22795-99-9, it is a common heterocyclic compound, the chiral-catalyst compound, its synthesis route is as follows.,22795-99-9

0.53 g (1.5 mmol) of compound 3a prepared in Preparation 8 was dissolved in 10 ml of dry toluene, 0.39 ml of thionyl chloride was added,Argon gas was heated at 60 ¡ã C for 1 hour and evaporated to dryness. 10 ml of anhydrous DCM was added,(S) -2-aminomethyl-1-ethylpyrrole 0.23g under ice-water bath, the reaction was stirred at room temperature for 8 hours and then diluted with 50ml DCM,The organic layer was washed with saturated aqueous sodium bicarbonate solution and saturated sodium chloride solution respectively for 3 times. The organic layer was dried over Na2SO4, filtered and evaporated to give a yellowish oil, which was separated by a medium pressure silica gel column.Mobile phase petroleum ether: ethyl acetate 3: 1, the product fractions were collected and evaporated to dryness to give a yellowish oil 0.593g, yield 85.2percent.

With the rapid development of chemical substances, we look forward to future research findings about (S)-(1-Ethylpyrrolidin-2-yl)methanamine

Reference£º
Patent; Beijing Nerve Surgical Department Institute; Liu Qian; Zhang Yazhuo; Yang Xiaoxiao; CN106366075; (2017); A;,
Chiral Catalysts
Chiral catalysts – SlideShare

1,3-Dimethyl-1H-benzo[d]imidazol-3-ium iodide, cas is 7181-87-5, it is a common heterocyclic compound, the chiral-catalyst compound, its synthesis route is as follows.,7181-87-5

A reaction vessel was charged with 1,3 dimethyl benzimidazole iodide (0.28 g, 1.0 mmol), silver(I) oxide (0.23 g,1.0 mmol), and 30 mL of dichloromethane. The reaction was heated at reflux in the absence of light for 20 h. The reaction solution was filtered through Celite to remove the formed solids, and the solvent was removed under reduced pressure. Yield: 0.16 g.

With the rapid development of chemical substances, we look forward to future research findings about 1,3-Dimethyl-1H-benzo[d]imidazol-3-ium iodide

Reference£º
Article; Miecznikowski, John R.; Bernier, Nicholas A.; Van Akin, Christopher A.; Bonitatibus, Sheila C.; Morgan, Maura E.; Kharbouch, Rami M.; Mercado, Brandon Q.; Lynn, Matthew A.; Transition Metal Chemistry; vol. 43; 1; (2018); p. 21 – 29;,
Chiral Catalysts
Chiral catalysts – SlideShare

(S)-2-(Methoxymethyl)pyrrolidine, cas is 63126-47-6, it is a common heterocyclic compound, the chiral-catalyst compound, its synthesis route is as follows.,63126-47-6

To a 100 mL RBF, was [ADD ][~)-^-INETHOXYMETHYL-PYNOLIDINE] (0.172 g, 1.5 mmol), and 50 mL [DICHLOROME ; HANE] at [0 oC] under nitrogen. 0.35 mL diisopropylethylamine (2.0 mmol) was added drop wise, and stirred for 10 min. 2- [CHLORO-6- (2-CHLOROPYRIDIN-4-YL)-3-METHYL-5-M-TOLYL-3H-PYRIMIDIN-4-ONE] (0.345 g, 1.0 mmol) was added in one portion, and stirred at [0 oC] to rt for 12 h. The mixture was diluted with 100 mL dichloromethane, washed with sat. [NAHC03] and brine. After purified by flash chromatography, the title compound was obtained in 0.40 g as pale yellow solid. MS (ES+): 425 [(M+H) +.]

With the rapid development of chemical substances, we look forward to future research findings about (S)-2-(Methoxymethyl)pyrrolidine

Reference£º
Patent; AMGEN INC.; WO2003/99808; (2003); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare

N,N’-Bis(salicylidene)-1,2-propanediamine, cas is 94-91-7, it is a common heterocyclic compound, the chiral-catalyst compound, its synthesis route is as follows.,94-91-7

General procedure: A mixture of diimine (10 mmol) and amidophosphite(10 mmol) in acetonitrile (20 mL) was refluxed for 1 h. Thesolvent was removed by distillation; the residue was dissolved inamethylene chloride-hexane mixture. The precipitated productwas recrystallized from benzene.

With the rapid development of chemical substances, we look forward to future research findings about N,N’-Bis(salicylidene)-1,2-propanediamine

Reference£º
Article; Pudovik, Michael A.; Kibardina, Ludmila K.; Terent’eva, Svetlana A.; Dobrynin, Alexey B.; Trifonov, Alexey V.; Burilov, Alexander R.; Phosphorus, Sulfur and Silicon and the Related Elements; vol. 194; 9; (2019); p. 861 – 865;,
Chiral Catalysts
Chiral catalysts – SlideShare

63126-47-6, (S)-2-(Methoxymethyl)pyrrolidine is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,63126-47-6

EXAMPLE 10 ; 8-12-[2-(2-(S)-Methoxymethyl-pyrrolidin-1-yl)-ethyl]-benzofuran-5-yl)-6,7-dihydro-5H-1,4,8a-triaza-s-indacene: Methanesulfonic acid 2-[5-(6,7-dihydro-5H-1,4,8a-triaza-s-indacen-8-yl)-benzo-furan-2-yl]-ethyl ester (0.085 mmol) described above was dissolved in acetonitrile (2 ml) followed by addition of 2-(S)-methoxymethylpyrrolidine (0.85 mmol) and potassium carbonate (0.425 mmol) and heated to 70¡ã C. for 24 hours. The reaction was cooled, filtered and concentrated. The residue was purified via preparative HPLC to give the title compound. [M+1]+ calc’d for C25H29N4O2, 417; found, 417.

The synthetic route of 63126-47-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Athersys, Inc.; US2006/9451; (2006); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare

Benzo-18-crown 6-Ether, cas is 14098-24-9, it is a common heterocyclic compound, the chiral-catalyst compound, its synthesis route is as follows.,14098-24-9

General procedure: The carbonyl substrate (0.1 g) is dissolved in 1-2 mL of anhydrous CHCl3 and 2.0 equiv of a benzocrown ether is added to the solution. To this mixture, CF3SO3H (8.0 equiv; H2SO4 may be used in some cases) is added dropwise with stirring. The reaction is stirred at room temperature for at least 2 h, after which, the mixture is poured over several grams of ice. The resulting solution is extracted three times with CHCl3. The organic phase is subsequently washed three times with water and dried over MgSO4 solution. Removal of the solvent provides the product.

As the rapid development of chemical substances, we look forward to future research findings about 14098-24-9

Reference£º
Article; Zielinski, Matthew E.; Tracy, Adam F.; Klumpp, Douglas A.; Tetrahedron Letters; vol. 53; 14; (2012); p. 1701 – 1704;,
Chiral Catalysts
Chiral catalysts – SlideShare

(S)-(1-Ethylpyrrolidin-2-yl)methanamine, cas is 22795-99-9, it is a common heterocyclic compound, the chiral-catalyst compound, its synthesis route is as follows.,22795-99-9

Into a clean and dried 100ml two necked round-bottomed flask equipped with magnetic stirrer and nitrogen set up, Compound 11 (3.0 gm, 0.0032 mol), 40ml 1:1 mixture of ACN : water and (R)?(1-ethylpyrrolidin-2-yl)methanamine (6.26 gm, 0.048 mol) were added at RT. The reaction mixture was heated at 65¡ãC and maintained for 6 hrs. The reaction was monitored by TLC using 60 percent ethyl acetate in hexane. After completion of the reaction, the reaction mass was concentrated and quenched with 30 ml of ice cold water and the obtained precipitate was extracted with ethyl acetate (3×50 ml), combined organic layers were dried over sodium sulfate and concentrated under reduced pressure to yield 4g of crude compound 12C, which was taken as it was for next step.

As the rapid development of chemical substances, we look forward to future research findings about 22795-99-9

Reference£º
Patent; BIOPHARMATI SA; SERGIO, Lociuro; ISLAM, Khalid; (46 pag.)WO2018/67663; (2018); A2;,
Chiral Catalysts
Chiral catalysts – SlideShare