Category: chiral-catalyst

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.141556-45-8,1,3-Dimesityl-1H-imidazol-3-ium chloride,as a common compound, the synthetic route is as follows.

General procedure: A mixture of pyrazine ligand 1 or 2 (1mmol), Li2PdCl4 (1mmol) and NaOAc (1mmol) in 20mL of dry methanol was stirred for 24hat rt. The yellow solids (yield: 92%) were collected by filtration and washed several times with methanol, which can be assigned to be palladacyclic dimers. Then, a Schlenk tube was charged with the above chloride-bridged palladacyclic dimers (0.5mmol), the corresponding imidazolium salt (1.25mmol) and tBuOK (2.5mmol) under nitrogen. Dry THF was added by a cannula and stirred at room temperature for 3h. The product was separated by passing through a short silica gel column with CH2Cl2 as eluent, the third band was collected and afforded the corresponding carbene adducts 3-10 as yellow solids. The characterization data for 3: Yield: 78%.

141556-45-8 1,3-Dimesityl-1H-imidazol-3-ium chloride 2734211, achiral-catalyst compound, is more and more widely used in various.

Reference£º
Short Survey; Xu, Chen; Wang, Zhi-Qiang; Yuan, Xiao-Er; Han, Xin; Xiao, Zhi-Qiang; Fu, Wei-Jun; Ji, Bao-Ming; Hao, Xin-Qi; Song, Mao-Ping; Journal of Organometallic Chemistry; vol. 777; (2015); p. 1 – 5;,
Chiral Catalysts
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.141556-45-8,1,3-Dimesityl-1H-imidazol-3-ium chloride,as a common compound, the synthetic route is as follows.

Synthesis of [(IMes)CuCl]. This synthesis is as reported in the literature; see S. Okamoto et al., J. Organomet. Chem. 2005, 690, 6001-6007. Tetrahydrofuran (7 mL) was added to a mixture of 1,3-bis(2,4,6-trimethylphenyl)imidazolium chloride (IMes-HCl, 1 mmol), CuCl (0.9 mmol), and sodium tert-butoxide (1 mmol). The suspension was stirred for 6 hours at room temperature, and then filtered through a pad of Celite. The filtrate was dried under vacuum. 1H NMR (500 MHz, CDCl3) delta=7.06 (s, 2H), 7.00 (s, 4H), 2.34 (s, 6H), 2.30 (d, 12H); 13C NMR (125 MHz, CDCl3) delta=178.7, 139.2, 134.9, 134.4, 129.3, 122.2, 21.1, 17.6; IR (KBr) 2914, 1485, 1400, 1234, 1076, 932, 862, 702 cm-1; Elemental analysis calcd for C21H24CuClN2: C, 62.52; H, 6.00; N, 6.94. Found: C, 62.33; H, 6.16; N, 6.86%.

The synthetic route of 141556-45-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Institut Catala d’Investigacio Quimica; Institucio Catalana de Recerca i Estudis Avancats; US2009/69569; (2009); A1;,
Chiral Catalysts
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.94-91-7,N,N’-Bis(salicylidene)-1,2-propanediamine,as a common compound, the synthetic route is as follows.

An ethanolic solution (5mL) of 1,2-diaminopropane (0.109g, 1mmol) was added dropwise to ethanolic solution (10mL) of salicylaldehyde (0.244g, 2mmol) and the resulting mixture was stirred for half an hour. Then, an ethanolic solution (10mL) of iron(III) perchlorate (0.354g, 1mmol) was added under continuous stirring condition and followed by the addition of 5mL ethanolic solution of 4 4?-bipyridine (0.156g, 1mmol). Resulting solution was then allowed to stir for one hour and filtered. Deep brown colored X-ray suitable square shaped crystals were obtained from the filtrate. Yield: 85%. Anal. Calcd. C, 54.74; H, 4.05; N, 9.46. Found: C, 54.73; H, 4.03; N, 9.44; FTIR: nu(C=N)=1614cm-1, nu(skeletal vibration)=1545cm-1, nu(ClO4-)=1087cm1; UV-Vis (methanol): 235, 322 and 509nm.

As the paragraph descriping shows that 94-91-7 is playing an increasingly important role.

Reference£º
Article; Chatterjee, Sourav; Sukul, Dipankar; Banerjee, Priyabrata; Adhikary, Jaydeep; Inorganica Chimica Acta; vol. 474; (2018); p. 105 – 112;,
Chiral Catalysts
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351498-10-7, 6,6′-((1E,1’E)-((2,3-Dimethylbutane-2,3-diyl)bis(azanylylidene))bis(methanylylidene))bis(2,4-di-tert-butylphenol) is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

N,N-Bis(3,5-di-tert-butylsalicylidene)-1 ,1 ,2,2-tetramethylethylenediamine (24, 0.73 g, 1 .3 mmol)was suspended in 10.0 mL of ethanol. The resulting suspension was heated to 80 c and stirred for 5minutes under argon balloon. Cobalt (II) acetate (0.24g, 1 .3 mmol) was then added, and the reactionmixture was stirred for another 2 hours at 80 00. The crimson red suspension was cooled down to roomtemperature in an ice bath and was filtered. The collected red solid was dried under vacuum to provide0.70 g of compound 25 (87%).

351498-10-7 6,6′-((1E,1’E)-((2,3-Dimethylbutane-2,3-diyl)bis(azanylylidene))bis(methanylylidene))bis(2,4-di-tert-butylphenol) 135404188, achiral-catalyst compound, is more and more widely used in various.

Reference£º
Patent; SOLSTICE BIOLOGICS, LTD.; BRADSHAW, Curt, W.; SAKAMURI, Sukumar; LIU, Dingguo; (83 pag.)WO2016/94677; (2016); A2;,
Chiral Catalysts
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673-06-3, D-Phenylalanine is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution ofDL-methionine (3.0 g, 20.1 mmol) in H2O (50 mL) was added 30% HBr (20 mL). The reaction mixture was stirred at 0 C for 10 min. A solution of sodium nitrite (1.7 g, 24 mmol) in H2O (50 mL) was added. The reaction mixture was stirred at 0 C for 30 min and thenwarmed to rt for 3 h. The reaction mixture was extracted withEtOAc (100 mL 3). The organic layer was washed with brine and dried over Na2SO4. The solid was filtered off, and the filtrate was concentrated under reduced pressure to give 3.6 g of intermediate 35c (83% yield).

As the paragraph descriping shows that 673-06-3 is playing an increasingly important role.

Reference£º
Article; Xue, Xiaoqian; Zhang, Yan; Wang, Chao; Zhang, Maofeng; Xiang, Qiuping; Wang, Junjian; Wang, Anhui; Li, Chenchang; Zhang, Cheng; Zou, Lingjiao; Wang, Rui; Wu, Shuang; Lu, Yongzhi; Chen, Hongwu; Ding, Ke; Li, Guohui; Xu, Yong; European Journal of Medicinal Chemistry; vol. 152; (2018); p. 542 – 559;,
Chiral Catalysts
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250285-32-6, 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: 4.23.1. [1,3-Bis(2,6-di-iso-propylphenyl)imidazol-2-ylidene] copper(I) chloride, (IPr)CuCl [23] An oven-dried Schlenk flask containing 1,3-bis(2,6-di-iso-propylphenyl) imidazolium chloride (849.0 mg, 2.00 mmol), CuCl (198.0 mg, 2.00 mmol), NaOt-Bu (192.0 mg, 2.00 mmol) was evacuated and refilled with argon three times. THF (10 mL) were added to this Schlenk flask. The resulting suspension was stirred at room temperature for 4 h. Then, it was filtered through Celite in glovebox. Yield: 81%; white powder; IR (KBr): 3160, 3137, 3070, 2968, 2926, 2869, 1963, 1577, 1469, 1456, 1405, 1383, 1327, 1114, 1104, 1212, 1058, 937, 946, 809, 765, 742, 699 cm 1; 1H NMR (400 MHz, CDCl3): d = 7.48 (t, J = 8.0 Hz, 2H), 7.29 (d, J = 7.6 Hz, 4H), 7.11 (s, 2H), 2.53-2.60 (m, 4H), 1.30 (d, J = 12 Hz, 12H), 1.22 (d, J = 6.8 Hz, 12H); 13C NMR (100 MHz, CDCl3): d = 180.6, 145.6, 134.4, 130.6, 124.2, 123.2, 28.8, 24.9, 23.9.

250285-32-6 1,3-Bis(2,6-diisopropylphenyl)imidazolium chloride 2734913, achiral-catalyst compound, is more and more widely used in various.

Reference£º
Article; Wu, Shaoxiang; Guo, Jiyi; Sohail, Muhammad; Cao, Chengyao; Chen, Fu-Xue; Journal of Fluorine Chemistry; vol. 148; (2013); p. 19 – 29;,
Chiral Catalysts
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2133-34-8, (S)-Azetidine-2-carboxylic acid is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 3 Methanol (40mL) was added to the (R)-4-phthalimido-2-chlorobutyric acid (5 g) and the mixture was stirred. To the mixture 80% hydrazine hydrate (2.3 g) was added with stirring, and the mixture was stirred at 40C overnight. Water (30 mL) was then added to the mixture with stirring, and 47% sulfuric acid (13 mL) was added. The mixture was stirred at room temperature for 4 hours and the precipitate was filtered out. The filtrate was concentrated under reduced pressure to recover an aqueous solution of (R)-4-amino-2-chlorobutyric acid. A small amount of the solution was sampled to identify the molecular structure by NMR. The analytical data was as follows:1H-NMR (D2O): delta 2.15-2.45 (m,2H), 3.19 (t,2H), 4.45 (t, 1H) The solution was then placed in an ice bath and an aqueous sodium hydroxide solution (400 g/L) was added to the solution in order to adjust the pH of the solution to 2.0. Water was added to the solution to obtain about 130 g of solution. The resultant solution was heated to about 90C with stirring. Magnesium hydroxide (1.0 g) was added to the solution and the solution was stirred for 5 hours to produce an aqueous solution of (S)-azetidine-2-carboxylic acid. A small amount of the solution was sampled to identify the molecular structure by NMR. The analytical data was as follows: 1H-NMR (CD3OD): delta 2.15 (m,1H), 2.58 (m,1H), 3.90 (m,1H), 4.02 (q,1H), 4.60 (t,1H) The solution was spontaneously cooled to room temperature. Sodium carbonate (2.1 g) and DIBOC (4.3 g) were added with stirring and the mixture was further stirred overnight. Hydrochloric acid (6N) was added to the solution in order to adjust the pH of the solution to 2.0. The resultant solution was extracted with ethyl acetate three times. The resultant organic solution was washed with a saturated brine solution and dried with sodium sulfate. The solvent in the mixture was then removed to recover (S)-N-(tert-butoxycarbonyl)azetidine-2-carboxylic acid (2.1 g) (yield 55%, optical purity 89.3 %e.e.). A small amount of the solution was sampled to identify the molecular structure by NMR. The analytical data was as follows:1H-NMR (CDCl3): delta 1.48 (s,9H), 2.40-2.60 (bs,2H), 3.80-4.00 (bs,2H), 4.80 (t,1H)

As the paragraph descriping shows that 2133-34-8 is playing an increasingly important role.

Reference£º
Patent; KANEKA CORPORATION; EP1415985; (2004); A1;,
Chiral Catalysts
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351498-10-7, 6,6′-((1E,1’E)-((2,3-Dimethylbutane-2,3-diyl)bis(azanylylidene))bis(methanylylidene))bis(2,4-di-tert-butylphenol) is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Compound Int-1a (733 mg, 1.33 mmol) was suspended in ethanol (10 mL) and the resulting suspension was heated to 80 C. and allowed to stir for 5 minutes. Compound Int-1b (236 mg, 1.33 mmol) was then added and the resulting reaction was allowed to stir at 80 C. for an additional 2 hours. The reaction was then cooled to room temperature using in an ice bath and the reaction mixture was filtered. The collected red solid was dried under vacuum to provide compound Int-1c (579 mg, 72%).

As the paragraph descriping shows that 351498-10-7 is playing an increasingly important role.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; Girijavallabhan, Vinay; Njoroge, F. George; Bogen, Stephane; Kerekes, Angela; Bennett, Frank; Huang, Ying; Nair, Latha; Pissarnitski, Dmitri; Verma, Vishal; Dang, Qun; Davies, Ian; Olsen, David B.; Stamford, Andrew; Vacca, Joseph P.; US2014/161770; (2014); A1;,
Chiral Catalysts
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1121-22-8,trans-Cyclohexane-1,2-diamine,as a common compound, the synthetic route is as follows.

General procedure: A methanolic solution (10mL) of (¡À)-trans-1,2-diaminocyclohexane (dach) (0.23g, 2.0mmol) in a Schlenk tube, was added dropwise to a methanolic solution (20mL) of salicylaldehyde-imidazolium salt H(iPr)sal(Me2Im+-X-) 3a-c (4.0mmol) into a 100mL Schlenk flask under nitrogen atmosphere. The reaction mixture was stirred under N2 at 60C for 3h. Then the solvent was partially removed under reduced pressure, and the yellow products of 4a-c were precipitated by the addition of ethyl acetate and kept in the refrigerator overnight. Solvent was decanted off and the obtained crude product was sonicated for 15min in Et2O (3¡Á25mL). Et2O was also decanted off and the residual solid was washed intensively with MeOH/Et2O mixture (1:2) to remove unreacted materials and then re-dissolved in MeOH. EtOAc was added slowly (?15min) to precipitate the products as pale yellow-dark orange solids which were collected by filtration and dried under vacuum. Samples of the isolated solids were characterized as follows.

The synthetic route of 1121-22-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Elshaarawy, Reda F.M.; Kheiralla, Zeinab H.; Rushdy, Abeer A.; Janiak, Christoph; Inorganica Chimica Acta; vol. 421; (2014); p. 110 – 122;,
Chiral Catalysts
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1121-22-8,trans-Cyclohexane-1,2-diamine,as a common compound, the synthetic route is as follows.

Into a solution containing 1,6-diisocyanatohexane (4.03 grams, 24 mmol; obtained from Sigma-Aldrich Fine Chemicals) and a 1:1 mixture of hexane and tetrahydrofuran (100 milliliters) stirring at room temperature was added a solution containing triethylene glycol monomethacrylate (5.24 grams, 24 mmol; obtained as CD570 from Sartomer Company Inc., Exton, Pa.) dissolved in a 1:1 mixture of hexane and tetrahydrofuran (10 milliliters) and dibutyltin dilaurate (0.075 grams, 0.12 mmol (obtained from Sigma-Aldrich Fine Chemicals) as the catalyst. The mixture was stirred and heated to an internal temperature of 40 C. The progress of the reaction was monitored by 1H-NMR spectroscopy for consumption of the triethylene glycol monomethacrylate reactant. The mixture was cooled to about 15 C. temperature, after which to this mixture was added dropwise a solution of trans-1,2-diaminocyclohexane (1.37 grams, 12 mmol; obtained as a racemic mixture of (1R,2R) and (1S,2S) stereoisomers from Sigma-Aldrich Fine Chemicals) dissolved in a 1:1 mixture of hexane and tetrahydrofuran (10 milliliters). The reaction mixture was stirred for 1 hour while warming up to room temperature. FTIR spectroscopic analysis of a reaction sample showed little unreacted isocyanate (peak at 2180 cm-1, sample prepared as a KBr pellet). Any residual isocyanate reagent was quenched by addition of methanol (5 milliliters). The reaction mixture was then filtered by vacuum filtration to give 6.13 grams of a solid product as a white powder (58 percent yield). 1H-NMR spectroscopic analysis of the solid was performed in DMSO-d6 (300 MHz) at room temperature (25 C.) and exhibited spectral assignments that matched those found for the compound in Example XVIII. The product was believed to be of the formulae

The synthetic route of 1121-22-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Xerox Corporation; US2006/122415; (2006); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare