Downstream synthetic route of 1121-22-8

1121-22-8, The synthetic route of 1121-22-8 has been constantly updated, and we look forward to future research findings.

1121-22-8, trans-Cyclohexane-1,2-diamine is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of the corresponding sulfonyl chloride (26.0mmol) in 26mL of dichloromethane at 0C, was added rapidly ethyl-1,2-diamine, propyl-1,3-diamine, or (rac)-cyclohexane-1,2-diamine (10eq., 3.0M). The mixture was allowed to reach room temperature and was stirred during 10h. The crude mixture was filtered and the obtained oil was concentrated under reduced pressure. Then, 10mL of ice-water were added to the concentrated mixture and a solid appeared which was filtrated and washed with cool water and dried under vacuum for 12h.

1121-22-8, The synthetic route of 1121-22-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Perez, Carlos; Diaz-Garcia, C. Vanesa; Agudo-Lopez, Alba; Del Solar, Virginia; Cabrera, Silvia; Agullo-Ortuno, M. Teresa; Navarro-Ranninger, Carmen; Aleman, Jose; Lopez-Martin, Jose A.; European Journal of Medicinal Chemistry; vol. 76; (2014); p. 360 – 368;,
Chiral Catalysts
Chiral catalysts – SlideShare