22795-99-9, (S)-(1-Ethylpyrrolidin-2-yl)methanamine is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Example 7 (S)-(+)-N-[(1-Ethyl-2-pyrrolidinyl)methyl]-2-amino-3-bromo-5,6-dimethoxybenzamide (Method A) To a solution of 2-amino-3-bromo-5,6-dimethoxybenzoic acid (0.96 g, 3 mmol) and triethylamine (0.58 ml, 4.2 mmol) in 15 ml tetrahydrofuran/ /dichloromethane (1:1) was added ethyl chloroformate (0.32 ml, 3.4 mmol) at -20¡ã C. After stirring for 45 min. at -20¡ã C. a solution of (2S)-(-)-1-ethyl-2-aminomethylpyrrolidine in 10 ml dichloromethane was added at -20¡ã C. After stirring for 3 h at room temperature the mixture was washed with water and extracted with 0.5M HCl. The aqueous phase was made alkaline and extracted twice with dichloromethane. Drying (Na2 SO4) and evaporation gave 0.45 g crude material which was purified by chromatography on a C18 reversed phase column with H2 O/MeOH/NH3 40:60:0.3 as eluent to give 0.25 g (22percent) pure product as an oil. Anal. (C16 H24 BrN3 O3): Calcd: C, 49.75; H, 6.26; N, 10.88. Found: C, 49.90; H, 6.31; N, 10.69. 1 H-NMR (CDCl3):delta1.11 (t,CH3), 1.7-3.9 (multiplets, 11 H), 3.80 and 3.82 (two s, (OMe)2), 5.80 (b, NH2), 7.14 (s,4-H), 7.9 (b, NH)ppm. 13 C-NMR (CDCl3):delta167.0 (CONH), 148.1, 143.7, 140.9, 120.3, 113.0, 104.9 (aromatic) ppm., 22795-99-9
The synthetic route of 22795-99-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Astra Lakemedel Akteibolag; US5240957; (1993); A;,
Chiral Catalysts
Chiral catalysts – SlideShare