602-09-5, [1,1′-Binaphthalene]-2,2′-diol is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
(1) Sodium hydride (0.7 g, 17.5 mmol) and 20 ml of anhydrous THF were added to a reaction flask equipped with a stirring apparatus, and stirred. a mixture of BINOL (2 g, 7.0 mmol) and 15 ml of anhydrous THF was added dropwise to the reactor through a constant pressure dropping funnel at 0 C, after completion, in this state for at least 15 minutes;To the reactor, chloromethyl methyl ether (1.33 ml, 17.5 mmol) was added, and after the addition, the temperature was raised to room temperature, stirring was continued, and the reaction was stopped by TLC until the starting point disappeared; then 100 ml of water was added to the reactor. The organic phase was separated with a sep. funnel, and the aqueous phase was extracted three times with ethyl acetate. The organic phase was combined and washed twice with saturated sodium hydrogen carbonate and brine and dried over anhydrous sodium sulfate. The solvent was removed under reduced pressure and purified by silica gel column chromatography (ethyl ether: ethyl acetate = 20:1, v/v)The compound of formula IIa was obtained in a yield of 88%
The synthetic route of 602-09-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Guangdong Hao Shun Oudisi Technology Co., Ltd.; East China University of Science and Technology; Wang Limin; Liu Xianghai; Cheng Xiaorong; Tian He; Cheng Yi; Han Jianwei; Lv Jiale; (12 pag.)CN109796369; (2019); A;,
Chiral Catalysts
Chiral catalysts – SlideShare