As a common heterocyclic compound, it belongs to quinuclidine compound,Quinuclidine-4-carboxylic acid hydrochloride,40117-63-3,Molecular formula: C8H14ClNO341,mainly used in chemical industry, its synthesis route is as follows.,22795-99-9
General procedure: In a clean and dry Tiny-clave reactor covered with aluminum foil, 1-iodo-m-carborane (0.09 mmol), amine (0.135 mmol), base (0.27 mmol) and ligand (4 molpercent with respect to carborane) were solved in degassed dry THF (1 mL). The catalyst (2 molpercent with respect to carborane) was added and the solution was degassed one more time. The reactor was closed and filled with the required pressure of CO, placed in a pre heated oil bath and heated at 85?C. Progress of the reaction was monitored by GC-MS analysis. After finishing the reaction, the oil bath was removed, cooled to room temperature and the CO was flushed with nitrogen. The reaction mixture was filtered through a celite bed. The celite was washed with ethyl acetate and the collected filtrates were concentrated and purified by column chromatography. Conditions were as follows:Compound 1: chloroform/ethanol 75/25; Compound 2: chloroform/ethanol 95/05; Compound 3: chloroform/ethanol 92/08; Compound 4: chloroform/ethanol 92/08
With the synthetic route has been constantly updated, we look forward to future research findings about (S)-(1-Ethylpyrrolidin-2-yl)methanamine,belong chiral-catalyst compound
Reference£º
Article; Gona, Kiran Babu; Go?mez-Vallejo, Vanessa; Llop, Jordi; Tetrahedron Letters; vol. 54; 8; (2013); p. 941 – 944;,
Chiral Catalysts
Chiral catalysts – SlideShare