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Chiral Co(III)-salen complex supported over highly ordered functionalized mesoporous silica for enantioselective aminolysis of racemic epoxides

Here we demonstrate the synthesis of a novel chiral Co(iii)-salen complex supported functionalized 2D-hexagonal mesoporous silica material Co(iii)@AFS-1. This material has shown excellent catalytic activity for the regio- and enantioselective asymmetric ring opening (ARO) of terminal and meso epoxides using various aromatic as well as cyclic amines to produce chiral beta-amino alcohols having very good enantioselectivities (ee > 99%) at ambient temperature under solvent-free neat conditions.

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Reference£º
Chiral Catalysts,
Chiral catalysts – SlideShare