Extracurricular laboratory: Synthetic route of 542-58-5

The article 《Reaction of cyclic ketals of ethylene glycol with hydrogen chloride》 also mentions many details about this compound(542-58-5)Formula: C4H7ClO2, you can pay attention to it, because details determine success or failure

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-Chloroethyl acetate( cas:542-58-5 ) is researched.Formula: C4H7ClO2.Musavirov, R. S.; Mullakhmetova, Z. F.; Nedogrei, E. P.; Kantor, E. A.; Rakhmankulov, D. L.; Paushkin, Ya. M. published the article 《Reaction of cyclic ketals of ethylene glycol with hydrogen chloride》 about this compound( cas:542-58-5 ) in Doklady Akademii Nauk SSSR. Keywords: ethanediol cyclic ketal ring cleavage; hydrogen chloride reaction cyclic ketal; chloroethyl carboxylate. Let’s learn more about this compound (cas:542-58-5).

I [R = R1 = Me; RR1 = (CH2)4, (CH2)5] were saturated with dry HCl and then heated 2 h at 150° to give AcOCH2CH2Cl, R2(CH2)4CO2CH2CH2Cl (R2 = 1-cyclopentenyl), and R3(CH2)5CO2CH2CH2Cl (R3 = 1-cyclohexenyl), resp., in low yields.

The article 《Reaction of cyclic ketals of ethylene glycol with hydrogen chloride》 also mentions many details about this compound(542-58-5)Formula: C4H7ClO2, you can pay attention to it, because details determine success or failure

Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare