Reference of 23190-16-1, An article , which mentions 23190-16-1, molecular formula is C6H5CH(NH2)CH(C6H5)OH. The compound – (1R,2S)-(?)-2-Amino-1,2-diphenylethanol played an important role in people’s production and life.
Enantioselective Copper Catalyzed Alkyne-Azide Cycloaddition by Dynamic Kinetic Resolution
The copper(I) catalyzed alkyne-azide cycloaddition (CuAAC), a click reaction, is one of the most powerful catalytic reactions developed during the last two decades. Conducting CuAAC enantioselectively would add a third dimension to this reaction and would enable the direct synthesis of alpha-chiral triazoles. Doing so is demanding because the two precursors have linear geometries, and the triazole product is a flat heterocycle. Designing a chiral catalyst is further complicated by the complex mechanism of CuAAC. We report an enantioselective CuAAC (E-CuAAC), enabled by dynamic kinetic resolution (DKR). The E-CuAAC is high yielding and affords up to 99:1 er. The E-CuAAC can directly generate alpha-chiral triazoles in a complex molecular environment.
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Chiral Catalysts,
Chiral catalysts – SlideShare