Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn¡¯t involve a screen. 21436-03-3, C6H14N2. A document type is Article, introducing its new discovery., 21436-03-3
Phosphoramides and thiophosphoramides were prepared from optically pure C2-symmetric 1,2-diamines and were used as chiral organocatalysts in the asymmetric Michael additions of aldehydes and ketones to N-substituted maleimides. The 1,2-diphenylethane-1,2-diamine derived thiophosphoramide, which could be prepared in good yield in a one-step procedure, was found to be more active and selective catalyst in the addition of aldehydes to various maleimide derivatives, when compared to sulfonamides having the same backbone. Products resulted in reactions of ketones with maleimides were also obtained in high yields and enantioselectivities. The thiophosphoramide derivative was also efficient in the asymmetric conjugate addition of carbonyl compounds to beta-nitrostyrene and in the reaction of nitromethane with alpha,beta-unsaturated ketones. Based on results obtained with (thio)phosphoramides in asymmetric additions to maleimides it was suggested that a weaker, more flexible hydrogen-bonding of the rigid electrophile to the catalyst is responsible for the improved performance of these bifunctional organocatalysts, as compared with sulfonamides. (Figure presented.).
But sometimes, even after several years of basic chemistry education,, 21436-03-3 it is not easy to form a clear picture on how they govern reactivity! Read on for other articles about 21436-03-3!
Reference£º
Chiral Catalysts,
Chiral catalysts – SlideShare