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Effective construction of quaternary stereocenters by highly enantioselective alpha-amination of branched aldehydes

A highly efficient enantioselective alpha-amination of branched aldehydes with azadicarboxylates promoted by chiral proline-derived amide thiourea bifunctional catalysts was developed for the first time, affording the adducts bearing quaternary stereogenic centers with excellent yields (up to 99%) and enantioselectivities (up to 97% ee).

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Reference£º
Chiral Catalysts,
Chiral catalysts – SlideShare