A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 23190-16-1, Name is (1R,2S)-(?)-2-Amino-1,2-diphenylethanol, molecular formula is C6H5CH(NH2)CH(C6H5)OH. In a Article£¬once mentioned of 23190-16-1, Product Details of 23190-16-1
Studies on reaction conditions and new entry to chiral ligands in the chiral lithium amide-mediated enantioselective aldol reaction
Reaction conditions for the enantioselective aldol reaction of 2,2-dimethyl-3-pentanone (3) and benzaldehyde using the chiral lithium amide 1b as a chiral auxiliary were thoroughly investigated. All three procedures, that is, (1) the combined use of lithium diisopropylamide and the chiral lithium amide 1b, (2) the use of an excess of the chiral lithium amide 1b, and (3) the regeneration of the chiral lithium amide 1b, afforded the aldol 4 in about 90% yield and 70% enantiomeric excess (ee). Investigation of the effects of solvent by utilizing 1-naphthaldehyde revealed that in tetrahydrofuran, (S,S)-aldol 5 of 77% ee was obtained as the major product, while in ether (R,R)-5 became the major isomer (38% ee). Furthermore, addition of hexamethylphosphoric triamide caused a dramatic change of stereoselectivity, and (S,S)-5 of 70% ee was obtained in ether with 20 eq of hexamethylphosphoric triamide. The aldol 4 of 74% ee was obtained when the new chiral lithium amide 6b was used.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data.Product Details of 23190-16-1, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 23190-16-1, in my other articles.
Reference£º
Chiral Catalysts,
Chiral catalysts – SlideShare