Chiral catalyst

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-Chloroethyl acetate( cas:542-58-5 ) is researched.Category: chiral-catalyst.Mastagli, Pierre; De Nanteuil, Michel published the article 《Reaction of titanium tetrachloride with ketone [ethylene ketals]》 about this compound( cas:542-58-5 ) in Comptes Rendus des Seances de l’Academie des Sciences, Serie C: Sciences Chimiques. Keywords: acetal titanium tetrachloride reaction; dioxolane titanium tetrachloride reaction; titanium tetrachloride acetal reaction. Let’s learn more about this compound (cas:542-58-5).

TiCl4 attacks cyclohexanone ethylene ketal (I, RR1 = cyclohexyl) (Ia) to give 2-chloroethyl 6-(1-cyclohexen-1-yl)caproate (II). This reaction was extended to several cyclic and linear ketone ethylene ketals. TiCl4 effects a kind of oxidation-reduction on 2 mols. of ethylene ketal leading to an ester and an alkene according to the general equation: I (R = R7CH2, R1 = R2) →R2CO2CH2CH2Cl (III) + R1CH:CR2CH2R1. The alc. part of III arises from the glycol forming the dioxolane ring. A cyclic ketone gives an olefinic ester. The mechanism of the reaction was not determined The exptl. results are summarized in the table; also IV gave 30% II by the same procedure. Thus, 0.5 mole TiCl4 was added dropwise to 1 mole ketal in CH2Cl2 with ice-bath cooling, kept overnight, hydrolyzed, washed with H2O, and distilled Characterization of the esters marked (a) in the table was made by reaction of the corresponding Et ester with ClCH2CH2OH in the presence of (PrO)4Ti; those marked (b) by esterification of the corresponding acid with ClCH2CH2OH; and those marked (c) by IR and N.M.R. anal. In the reaction of TiCl4 with acetone ethylene ketal, AcOCH2CH2Cl was obtained, but the formation of isobutene was not demonstrated since it forms high polymers in the presence of Lewis acids.

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Chiral Catalysts,
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SDS of cas: 22468-26-4. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 4-Hydroxypicolinic acid, is researched, Molecular C6H5NO3, CAS is 22468-26-4, about Discovery of potent c-MET inhibitors with new scaffold having different quinazoline, pyridine and tetrahydro-pyridothienopyrimidine headgroups.

Cellular mesenchymal-epithelial transition factor (c-MET) is closely linked to human malignancies, which makes it an important target for treatment of cancer. In this study, a series of 3-methoxy-N-phenylbenzamide derivatives, N-(3-(tert-butyl)-1-phenyl-1H-pyrazol-5-yl) benzamide derivatives and N1-(3-fluoro-4-methoxyphenyl)-N3-(4-fluorophenyl) malonamide derivatives were designed and synthesized, some of them were identified as c-MET inhibitors. Among these compounds with new scaffolds having different quinazoline, pyridine and tetrahydro-pyridothienopyrimidine head groups, compound 11c, 11i, 13b, 13h exhibited both potent inhibitory activities against c-MET and high anticancer activity against tested cancer cell lines in vitro. In addition, kinase selectivity assay further demonstrated that both 13b and 13h are potent and selective c-MET inhibitors. Mol. docking supported that they bound well to c-MET and VEGFR2, which demonstrates that they are potential c-MET RTK inhibitors for cancer therapy.

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Chiral Catalysts,
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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2-Chloroethyl acetate, is researched, Molecular C4H7ClO2, CAS is 542-58-5, about Electron capture detection and formation of negative ions in isomeric chlorinated ethyl acetates.Product Details of 542-58-5.

Gas chromatog. (GC)/electron capture detection and GC/neg. ion chem. ionization mass spectrometry were compared to each other to investigate ionic processes involved and to develop new derivatives for analyzing halogenated carboxylic acids which are, for example, of considerable importance in the environment. The results show that the response factors for isomeric chlorinated esters depend markedly on structural features and on neg. ion formation mechanisms and ion composition

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Chiral Catalysts,
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Name: 4-(Hydroxymethyl)-1,3-dioxolan-2-one. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 4-(Hydroxymethyl)-1,3-dioxolan-2-one, is researched, Molecular C4H6O4, CAS is 931-40-8, about Heterogeneous synthesis of glycerol carbonate from glycerol and dimethyl carbonate catalyzed by LiCl/CaO. Author is Tang, Ying; Xue, Yu Ying; Li, Zhaoyi; Yan, Tianlan; Zhou, Rui; Zhang, Zhiping.

In this article, a CaO-based catalyst was prepared by impregnating chloride salts on CaO to develop a highly efficient heterogeneous catalyst for the synthesis of glycerol carbonate (GC) from glycerol and di-Me carbonate. LiCl/CaO exhibited a high catalytic activity under moderate reaction conditions. The effects of the LiCl loadings, the amount of catalyst and the calcination temperature on the catalytic activity were investigated. The highest yield of 94.19% glycerol carbonate was obtained at 65°C on CaO loaded with 10% LiCl after 1 h, and the catalyst had high stability in reusing work. SEM (SEM), X-ray diffraction (XRD), BET, CO2-TPD, XPS and thermalgravity (TG) were used to characterize the prepared catalyst. It was found that the high catalytic activity of CaO after modification with LiCl is associated with the structural aspects and the amount of basicity of the catalyst. The Li2O2 species, which is a strong basic site that is formed by the substitution of the Ca2+ in CaO lattice by Li+, has great activity for transesterification.

Here is a brief introduction to this compound(931-40-8)Name: 4-(Hydroxymethyl)-1,3-dioxolan-2-one, if you want to know about other compounds related to this compound(931-40-8), you can read my other articles.

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Chiral Catalysts,
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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 931-40-8, is researched, SMILESS is O=C1OCC(CO)O1, Molecular C4H6O4Journal, Liaoning Huagong called Preparation of catalyst from natural eggshell waste and its application in the synthesis of glycerol carbonate, Author is Wang, Sun-bo; Wang, Song; Li, San-xi, the main research direction is transesterification catalyst eggshell glycerol dimethyl carbonate dioxolanone preparation.Safety of 4-(Hydroxymethyl)-1,3-dioxolan-2-one.

Eggshell is a kind of waste with huge production Its main component is calcium carbonate, which can be used as the source of base catalyst, calcium oxide. Turning egg shell waste into base catalyst can turn waste into useful material and is in line with the concept of green chem. In this paper, the catalyst was prepared from waste egg shell, and its application in the synthesis of glycerol carbonate was explored. The property of prepared catalyst was investigated by FTIR, XRD, SEM and EDS. The investigation results indicated that the catalyst prepared from waste eggshells through adding dolomite and talcum powder by calcined at 1250°C for 4 h showed high catalytic ability. The prepared catalyst can be used in the synthesis of glycerol carbonate and has good activity. The optimal conditions for the synthesis of glycerol carbonate were determined as follows: the catalyst amount 5% (wt), the molar ratio of DMC to glycerol 3:1, the reaction temperature 80°C and the reaction time 2 h. Under above conditions, glycerol conversion rate reached 94.67%. However, the stability of the catalyst in the transesterification reaction is poor.

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Chiral Catalysts,
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HPLC of Formula: 931-40-8. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 4-(Hydroxymethyl)-1,3-dioxolan-2-one, is researched, Molecular C4H6O4, CAS is 931-40-8, about The role of impurities in the La2O3 catalyzed carboxylation of crude glycerol. Author is Razali, N. A.; Conte, M.; McGregor, J..

The direct carboxylation of crude glycerol, obtained as a byproduct of bio-diesel synthesis, with CO2 has been investigated over lanthanum oxide as a heterogeneous catalyst for the first time. Adiponitrile is employed as a dehydrating agent in order to shift the reaction equilibrium to the product side. The selectivity of the reaction towards glycerol carbonate when using crude glycerol is significantly reduced as compared to employing refined glycerol: 2.3% cf. 17% resp. Glycerol conversion, however remains approx. constant: 54% cf. 58%. In order to understand the role of the impurities present in crude glycerol, model systems consisting of refined glycerol and one or more of water, methanol, Me palmitate (as a model fatty acid Me ester), and sodium methoxide have been prepared and used as reaction media to systematically evaluate their effect. All of these impurities are seen to reduce the selectivity towards glycerol carbonate, instead favoring the formation of 4-(hydroxymethyl)oxazolidin-2-one, with the exception of methanol where no detrimental effect is observed and the measured selectivity increases slightly to ca. 22%. This effect is ascribed, in part, to improved mass transfer as a consequence of an increased solubility of carbon dioxide in the liquid media when methanol is present. Addnl., adiponitrile is observed to play a crucial role in the reaction mechanism beyond its simple role as a dehydrating agent. These results provide insights into the required purification steps for crude glycerol, and suggest the possibility of employing crude glycerol directly, and its use as a chem. feedstock; in both cases by minimizing costly separation and purification steps.

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Chiral Catalysts,
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SDS of cas: 10466-61-2. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: H-Leu-NH2.HCl, is researched, Molecular C6H15ClN2O, CAS is 10466-61-2, about Influence of pseudoallylic strain on the conformational preference of 4-methyl-4-phenylpipecolic acid derivatives. Author is Sugg, Elizabeth E.; Griffin, Jane F.; Portoghese, Philip S..

The preparation of the title compounds [cis- and trans-I; R = OH, NHCH(CONH2)CH2CHMe2; R1 = CO2CMe3, H] was described. Double-resonance proton spectroscopy revealed that the conformational preference of substituents attached to the ring depends on the hybridization of the piperidine N. In the free amino acids or leucinamide dipeptides, the C-2 carboxyl group is equatorial. Introduction of a carbamyl moiety on the piperidine N induces a change in the ring conformation such that the C-2 carboxyl group is axial, despite a cis-diaxial interaction with the C-4 substituent. The inverted conformational preference of the C-2 and C-4 groups in the tert-butoxycarbonyl and unprotected derivatives is attributed to a severe steric interaction between the partially sp2 hybridized NCO moiety in the carbamate group and an equatorial C-2 carboxyl group. The x-ray crystal structures of both cis- and trans-I (R = OH, R1 = CO2CMe3) corroborate the solution spectroscopic studies and the concept of pseudoallylic strains in substituted piperidine carbamates. In addition, comparison of the two crystallog. determined structures indicates that H bonding to the carbonyl of the carbamate produces delocalization into the N-C bond, resulting in a shorter bond and more planar piperidyl N. The conformational preference afforded by pseudoallylic strain indicates that substituted pipecolic acids can be used in the design of conformationally restricted peptide analogs.

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Chiral Catalysts,
Chiral catalysts – SlideShare

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 4-(Hydroxymethyl)-1,3-dioxolan-2-one, is researched, Molecular C4H6O4, CAS is 931-40-8, about Recent development of heterogeneous catalysis in the transesterification of glycerol to glycerol carbonate, the main research direction is review glycerol carbonate heterogeneous catalysis transesterification.COA of Formula: C4H6O4.

A review. Glycerol is one of the most crucial byproducts in the production of biodiesel, and owing to its oversaturation in the market, several synthetic strategies have been developed to transform it into other higher value-added products such as glycerol carbonate, epichlorohydrin, 1,3-propanediol, etc. Amongst them, glycerol carbonate is considered to be the most valuable product. Considering the facile separation and reusability of catalyst, heterogeneous base catalysts have attracted considerable attention due to the obvious advantages over Bronsted acid and homogeneous base catalysts in the transesterification of glycerol. Herein, we will give a short overview on the recent development of the heterogeneous catalysis in the transesterification of glycerol with dialkyl carbonate. Focus will be concentrated on the heterogeneous base catalysts including alk.-earth metal oxides (MgO, CaO, and mixed oxides), hydrotalcites, zeolites, clinoptilolites, organic bases, etc. Their catalytic mechanisms during the heterogeneous process will be elucidated in detail.

There is still a lot of research devoted to this compound(SMILES：O=C1OCC(CO)O1)COA of Formula: C4H6O4, and with the development of science, more effects of this compound(931-40-8) can be discovered.

Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 931-40-8, is researched, SMILESS is O=C1OCC(CO)O1, Molecular C4H6O4Journal, Materials Today Communications called Feasibility of polyamines and cyclic carbonate terminated prepolymers in polyurethane/polyhydroxyurethane synthesis, Author is Kotanen, Soilikki; Laaksonen, Timo; Sarlin, Essi, the main research direction is cyclic carbonate terminated prepolymer polyurethane polyhydroxyurethane polyamine.Computed Properties of C4H6O4.

Polyurethanes are a well-established part of adhesive markets. However due to the toxicity of di-isocyanates used in the synthesis, finding an alternative route to synthesize polyurethanes is increasingly important. One strategy is to use cyclic carbonate terminated prepolymers with polyamines to yield polyhydroxyurethanes. This research highlights the possibility to use com. available polyurethane prepolymers with different isocyanate chemistries for cyclic carbonate terminated prepolymer synthesis with the help of glycerol carbonate and a catalyst. These synthesized prepolymers were used in a screening study with different com. available low toxic amines. It was observed that when secondary amines were used, the reaction advanced at room temperature with no further heating required. The development of lap shear strength over time on stainless steel, gel content, tensile strength and elongation were measured from room temperature cured polymers. The synthesized polyurethane/polyhydroxyurethane (PU/PHU) hybrid materials had high initial lap shear strength close to current industrial polyurethane adhesives. The strength development over time was negligible. Full conversions were seen within one month from the reaction. Tensile strength levels were slightly lower than typical industrial polyurethane adhesives. Even though the lap shear strength results and gel contents at room temperature were on a good level, curing at elevated temperature had a pos. impact on them. The best performing combination was cyclic carbonate functionalized hexamethylene di-isocyanate prepolymer with multifunctional polyethyleneimine amine. In short, di-isocyanate free PU/PHU hybrid materials were successfully synthesized from com. raw materials and their performance was comparable with current industrial polyurethane adhesives.

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Chiral Catalysts,
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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: H-Leu-NH2.HCl(SMILESS: N[C@@H](CC(C)C)C(N)=O.[H]Cl,cas:10466-61-2) is researched.COA of Formula: C9H16O2. The article 《Ultrasound and ZnCl2 promoted synthesis of phthaloyl derivatives of α-amino carboxamides》 in relation to this compound, is published in Synthesis. Let’s take a look at the latest research on this compound (cas:10466-61-2).

A new, one-step and racemization-free synthesis of phthaloyl derivatives of α-amino carboxamides is described. Under ultrasound, α-amino carboxamides and dipeptide derivatives react with monomethyl phthalate in the presence of BOP, ZnCl2 and i-Pr2NEt to afford the corresponding Nu-phthaloyl α-amino carboxamides or dipeptides in good to excellent yields. Cyclization of the intermediate Nu-[(o-methoxycarbonyl)benzoyl]amino carboxamides to the desired products was very slow when the reaction was conducted either in the absence of ZnCl2 and/or without sonication, but the process was greatly accelerated when both ZnCl2 and ultrasound were used.

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Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare