(S)-(1-Ethylpyrrolidin-2-yl)methanamine, cas is 22795-99-9, it is a common heterocyclic compound, the chiral-catalyst compound, its synthesis route is as follows.,22795-99-9
Into a clean and dried 100ml two necked round-bottomed flask equipped with magnetic stirrer and nitrogen set up, Compound 11 (3.0 gm, 0.0032 mol), 40ml 1:1 mixture of ACN : water and (R)?(1-ethylpyrrolidin-2-yl)methanamine (6.26 gm, 0.048 mol) were added at RT. The reaction mixture was heated at 65¡ãC and maintained for 6 hrs. The reaction was monitored by TLC using 60 percent ethyl acetate in hexane. After completion of the reaction, the reaction mass was concentrated and quenched with 30 ml of ice cold water and the obtained precipitate was extracted with ethyl acetate (3×50 ml), combined organic layers were dried over sodium sulfate and concentrated under reduced pressure to yield 4g of crude compound 12C, which was taken as it was for next step.
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Reference£º
Patent; BIOPHARMATI SA; SERGIO, Lociuro; ISLAM, Khalid; (46 pag.)WO2018/67663; (2018); A2;,
Chiral Catalysts
Chiral catalysts – SlideShare