As a common heterocyclic compound, it belongs to chiral-catalyst compound, name is D-Phenylalanine, and cas is 673-06-3, its synthesis route is as follows.,673-06-3
Synthesis of (R)-phenylalanine[0100] To a solution of D -phenylalanine (1.651 g, 10.0 mmol) in tert-butyl acetate (20 mL) at 0 C, was slowly added HC104 (0.85 mL, 15 mmol). The reaction mixture was stirred at room temperature for 12 h then washed with H20 (25 mL) and 1.0 M HC1 solution (15 mL). The resultant aqueous solution was adjusted to pH 9 by addition of 10 % K2C03 solution, and then extracted with dichloromethane (3 x 10 mL). The combined organic phases were dried with anhydrous Na2S04, filtered and concentrated to give an oil. This was purified by flashchromatography on silica gel, using a grading of ethyl acetate/hexane ((1 :5) to (2:5)), to give Al as a colorless oil; (2.020 g, 89.3%). Spectral data were in accordance with those published. [alpha]?5 : -39.5 (c = 0.33, CHC13); 1H-NMR (300 MHz, CDC13): delta 7.35-7.29 (m, 2H), 7.27-7.22 (m, 3H), 3.63 (dd, J= 6.0, 9.0 Hz, 1H), 3.09-3.02 (m, 1H), 2.89-2.82 (m, 2H), 1.47 (s, 2H), 1.44 (s, 9H); 13C NMR (300 MHz, CDC13): delta 174.34, 137.57, 129.39, 128.41 , 126.65, 81.12, 56.33, 41.29, 28.00; LRMS (ESI): calcd for: Ci3Hi9N02 [M + H]+ = 222.1 , obsd [M + H]+ = 222.1 , [M + Na]+ = 244.1 , obsd [M + Na]+ = 244.1.
With the complex challenges of chemical substances, we look forward to future research findings about 673-06-3,belong chiral-catalyst compound
Reference£º
Patent; THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE; YIN, Hang; CHENG, Kui; WO2012/99785; (2012); A2;,
Chiral Catalysts
Chiral catalysts – SlideShare