Tag: M.W:100-200

Name is trans-Cyclohexane-1,2-diamine, as a common heterocyclic compound, it belongs to chiral-catalyst compound, and cas is 1121-22-8, its synthesis route is as follows.,1121-22-8

General procedure: To a mortar were added 3,5-di-tert-butyl-2-hydroxybenzaldehyde (0.468 g, 2 mmol) and trans-cyclohexane-1,2-diamine (0.114 g,0.123 mL, 1 mmol), and these were mixed over 10 min. The product was recrystallized (CH2Cl2/EtOH 1:9) to give 1a as a bright yellow solid; yield: 0.487 g (89%).

With the complex challenges of chemical substances, we look forward to future research findings about trans-Cyclohexane-1,2-diamine

Reference£º
Article; Civicos, Jose F.; Coimbra, Juliana S. M.; Costa, Paulo R. R.; Synthesis; vol. 49; 17; (2017); p. 3998 – 4006;,
Chiral Catalysts
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As a common heterocyclic compound, it belongs to chiral-catalyst compound, name is trans-Cyclohexane-1,2-diamine, and cas is 1121-22-8, its synthesis route is as follows.,1121-22-8

General procedure: According to the same procedure described for 2a, white solid of2b was obtained in 71% yield. M.p. 178.5-179.5C. Anal. Calcd forC24H24N2O4 C, 71.27; H, 5.98; N, 6.93. Found: C, 71.20; H, 5.94;N, 6.92. IR (KBr, cm-1): 3434, 3190, 3051, 3025, 2940, 1650, 1612,1443, 1409, 1352, 1319, 1263, 981, 873, 799, 728, 661.

With the complex challenges of chemical substances, we look forward to future research findings about 1121-22-8,belong chiral-catalyst compound

Reference£º
Article; Yu, Yinghua; Chen, Jianxin; Meng, Suqin; Li, Chao; Lan, Meiying; Zhang, Zhichun; Journal of Molecular Catalysis A: Chemical; vol. 380; (2013); p. 104 – 111;,
Chiral Catalysts
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673-06-3, D-Phenylalanine is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

673-06-3, Embodiment 1 N-(Benzyloxycarbonyl)-D-phenylalanine A 15.0 g sample of D-phenylalanine was dissolved in 45 ml of aqueous solution containing 7.26 g of 50% sodium hydroxide. This solution was stirred at 0-10 C. as 16.3 g of benzyl chloroformate was added rapidly in portions. The resulting reaction was mildly exothermic, and shortly after addition, solids precipitated. An additional 45 ml of water and 3.63 g of 50% sodium hydroxide were added, causing most of the solids to redissolve. The reaction mixture was stirred for 20 minutes and then acidified with 6N hydrochloric acid. The resulting solids were filtered, washed with water and then with hexane, and dried by suction and then under vacuum to give 47 g of white solids. These solids dissolved in ether were washed twice with 1N hydrochloric acid and then with water, dried over MgSO4 and stripped to 35 C. at 2.5 mm Hg to give 27.7 g of the desired product as a colorless oil.

As the paragraph descriping shows that 673-06-3 is playing an increasingly important role.

Reference£º
Patent; Shell Oil Company; US4560515; (1985); A;,
Chiral Catalysts
Chiral catalysts – SlideShare

Name is trans-Cyclohexane-1,2-diamine, as a common heterocyclic compound, it belongs to chiral-catalyst compound, and cas is 1121-22-8, its synthesis route is as follows.,1121-22-8

A methanolic solution of ligand trans-cyclohexane-1,2-diamine(0.1142 g, 1 mmol) was added dropwise to a clear solution ofCopper(II) trifluoromethanesulfonate (0.1808 g, 0.5 mmol) inmethanol (10 mL). The resultant solution was stirred at roomtemperature for 6 h to produce a dark blue coloured solution. Thediffraction quality crystals of the titled complex were obtaineddirectly by slow evaporation of the deep bluish methanolic solutionat room temperature. Yield: 0.272 g, 75%, m.p: 258 C, Anal. Calc. forC14H32CuF6N4O8S2: C, 26.86; H, 5.15; N, 8.95. Found: C, 26.54; H,5.32, N, 8.78. Selected FT-IR (KBr), cm1: n(NH2) 3332e3279, n(CH2)2967e2861, n(OH) 3463, n(CueN) 628, n(CueO) 514. UVeVis [lmax(nm), epsilon (L mol1 cm1)]: 243 (8940), 548 (89).

With the complex challenges of chemical substances, we look forward to future research findings about trans-Cyclohexane-1,2-diamine

Reference£º
Article; Agrahari, Bhumika; Layek, Samaresh; Kumari, Shweta; Anuradha; Ganguly, Rakesh; Pathak, Devendra D.; Journal of Molecular Structure; vol. 1134; (2017); p. 85 – 90;,
Chiral Catalysts
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It is a common heterocyclic compound, the chiral-catalyst compound, (S)-(1-Ethylpyrrolidin-2-yl)methanamine, cas is 22795-99-9 its synthesis route is as follows.,22795-99-9

0.414 g (1 mmol) of compound 4a prepared in Preparation 9 was dissolved in 10 ml of anhydrous toluene, 0.39 ml of thionyl chloride was added, and the mixture was heated at 60 ¡ã C. under argon for 1 hour and then evaporated to dryness. 10 ml of anhydrous DCM was added,(S) -2-aminomethyl-1-ethylpyrrole 0.154g under ice-water bath, the reaction was stirred at room temperature for 8 hours, diluted with 50ml of EtOAc,Washed with saturated aqueous solution of NaHCO3, saturated NaCl three times, the organic layer was dried over Na2SO4, filtered and evaporated to give a yellowish oil,The residue was separated by a medium pressure silica gel column and the mobile phase petroleum ether: ethyl acetate 1: 1 (2percent TEA (triethylamine)). The product fractions were collected and evaporated to give 0.396 g as a yellowish oil, yield 75.6percent.

With the complex challenges of chemical substances, we look forward to future research findings about (S)-(1-Ethylpyrrolidin-2-yl)methanamine

Reference£º
Patent; Beijing Nerve Surgical Department Institute; Liu Qian; Zhang Yazhuo; Yang Xiaoxiao; CN106366075; (2017); A;,
Chiral Catalysts
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Name is D-Phenylalanine, as a common heterocyclic compound, it belongs to chiral-catalyst compound, and cas is 673-06-3, its synthesis route is as follows.,673-06-3

Step A. Preparation of Nalpha-(4-methylbenzenesulfonyl)-D-phenylalanine D-phenylalanine was reacted with 4-methylbenzenesulfonyl chloride under the conditions used in general procedure A giving the title compound which was recrystallized from ether (18%). LC-MS: 318 (M-H)-, 98% pure.

With the complex challenges of chemical substances, we look forward to future research findings about D-Phenylalanine

Reference£º
Patent; Stranix, Brent Richard; Sauve, Gilles; Bouzide, Abderrahim; Cote, Alexandre; Berube, Gervais; Soucy, Patrick; Zhao, Yongsen; Yelle, Jocelyn; US2002/151546; (2002); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare

As a common heterocyclic compound, it belong chiral-catalyst compound,trans-Cyclohexane-1,2-diamine,1121-22-8,Molecular formula: C6H14N2,mainly used in chemical industry, its synthesis route is as follows.,1121-22-8

[0395] The ligand was prepared using the method described by Gao. H-X; Zhang, H.; Yi, X-D; Xu, P.-P.; Tang, C.-L.; Wan, H.-L.; Tsai, K.-R.; Ikariya, T.; (Chirality 2000, 12, 383-388). [0396] 12.65 g of anhydrous magnesium sulphate (105.1 mmoles) and 4.2 ml of a racemic trans-1,2-diaminocyclohexane mixture (35.0 mmoles) were successively added to a solution of 6.66 ml of 2-pyridylaldehyde (70.0 mmoles) in 50 ml of absolute ethanol. [0397] The reaction mixture was stirred for 20 hours at ambient temperature (the solution turned yellow after stirring for three hours), heated for 2.5 hours under reflux, then filtered through a frit. [0398] The isolated solid was washed with dichloromethane. [0399] The total filtrate was concentrated completely under reduced pressure to isolate an ochre solid, which was re-crystallised from ethanol. [0400] 8.2 g of pale yellow crystals were obtained, which corresponded to a 80.1% yield. [0401] The characteristics were as follows: [0402] M.Pt: 140-141 C. (EtOH) (racemic mixture) (Lit: 127-129 C.: obtained by Belokon, Y N; North, M: Churkina, T D; Ikonnikov, N S; Maleev, V I; Tetrahedron 2001, 57, 2491-2498 for the stereoisomer 1S,2S, hexane-MeOH); [0403] 1H NMR/CDCl3: delta 8.51 (m, 2H, H1,2), 8.28 (s, 2H, H7,14), 7.84 (m, 2H, H4,17), 6.55-7.64 (m, 2H, H5,16), 7.14-7.21 (m, 2H, H3,18), 3.50 (m, 2H, H8, 13), 1,81 (m, 6H, H10,11 and H carried by carbons 9 and 12 located in the position cis (or trans) with respect to the adjacent nitrogen atoms), 1.40-1.53 (m, 2H, H carried by carbons 9 and 12 located in the trans (or cis) position with respect to the adjacent nitrogen atoms). [0404] 13C NMR/CDCl3: delta 161.42 (C7 and C14), 154.61 (C6 to C15), 149.21 (C1 and C2), 136.39 (C4 and C17), 124.43 (C3 and C18), 121.29 (C5 and C16), 73.53 (C8 and C13), 32.70 (C9 and C12), 24.33 (C10 and C11). [0405] FAB+ (NBA matrix): 293 (100%, M+1), 107 (52%, 2-pyridylaldimine+H+), 92 (38%, C5H4N-CH2+), 119 (25%, C5H4N-CHN-CH2+), 294 (23%, M+2), 204 (22%, [M-(2-pyridylidene)]+), 79 (21%, pyridine+), 187 (20%, M-[2-pyridylineamino]+), 585 (1%, 2M+1).

With the synthetic route has been constantly updated, we look forward to future research findings about trans-Cyclohexane-1,2-diamine,belong chiral-catalyst compound

Reference£º
Patent; Cellier, Pascal Philippe; Cristau, Henri-Jean; Spindler, Jean-Francis; Taillefer, Marc; US2003/236413; (2003); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare

As a common heterocyclic compound, it belongs to quinuclidine compound,Quinuclidine-4-carboxylic acid hydrochloride,40117-63-3,Molecular formula: C8H14ClNO112,mainly used in chemical industry, its synthesis route is as follows.,1121-22-8

General procedure: To a mortar were added 3,5-di-tert-butyl-2-hydroxybenzaldehyde (0.468 g, 2 mmol) and trans-cyclohexane-1,2-diamine (0.114 g,0.123 mL, 1 mmol), and these were mixed over 10 min. The product was recrystallized (CH2Cl2/EtOH 1:9) to give 1a as a bright yellow solid; yield: 0.487 g (89%).

With the complex challenges of chemical substances, we look forward to future research findings about trans-Cyclohexane-1,2-diamine,belong chiral-catalyst compound

Reference£º
Article; Civicos, Jose F.; Coimbra, Juliana S. M.; Costa, Paulo R. R.; Synthesis; vol. 49; 17; (2017); p. 3998 – 4006;,
Chiral Catalysts
Chiral catalysts – SlideShare

673-06-3, D-Phenylalanine is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred solution of D-Phenylalanine (15 g, 90.80 mmol, 1 equiv.) in 5% aqueous NaHCO3 (800 mL)at room temperature was added benzyl chloroformate (15.34 mL, 108.97 mmol, 1.2 equiv.) and resultingmixture was allowed to stir for 12 h. Diethyl ether (200 mL) was added to remove the excess of benzylchloroformate. Aqueous layer was acidified with 6 N hydrochloric acid to pH 1 and extracted with ethylacetate (300 mL ¡Á 3). Combined organic layers were dried with anhydrous MgSO4, filtered andconcentrated under reduced pressure to give compound 11 (27 g) as a white solid in quantitative yield.The product was directly used for next step without any further purification., 673-06-3

The synthetic route of 673-06-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Wan, Yang; Stanovych, Andrii; Gori, Didier; Zirah, Severine; Kouklovsky, Cyrille; Alezra, Valerie; European Journal of Medicinal Chemistry; vol. 149; (2018); p. 122 – 128;,
Chiral Catalysts
Chiral catalysts – SlideShare

D-Phenylalanine, cas is 673-06-3, it is a common heterocyclic compound, the chiral-catalyst compound, its synthesis route is as follows.,673-06-3

The 10mmolD-phenylalanie dissolved in 50 ml tetrahydrofuran, ice water bath to 0 C left and right, add triethylamine 20mmol. Then the 15mmol (Boc)2O into to the above-mentioned solution. 0 C left and right, reaction 60 min, then room temperature reaction 15h, after the reaction. The reaction solution with ethyl acetate extraction 2-3 time, remove the upper layer, pH is adjusted with acid, then dichloromethane is used for extraction 2-3 time. Merging the lower organic phase, dried with anhydrous sodium sulfate, concentrated solvent, get intermediate 1

With the synthetic route has been constantly updated, we look forward to future research findings about D-Phenylalanine,belong chiral-catalyst compound

Reference£º
Patent; Zunyi Medical College; Yang, Jiaqiang; Yang, Juan; Ceng, Fakui; Li, Peng; (9 pag.)CN105503947; (2016); A;,
Chiral Catalysts
Chiral catalysts – SlideShare