Tag: M.W:100-200

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《The infrared absorption spectra of some amide and dipeptide metal chelates》. Authors are Rosenberg, Andreas.The article about the compound:H-Leu-NH2.HClcas:10466-61-2,SMILESS:N[C@@H](CC(C)C)C(N)=O.[H]Cl).Recommanded Product: 10466-61-2. Through the article, more information about this compound (cas:10466-61-2) is conveyed.

The glycylglycino, leucinamido, leucinemethylamido, alanylglycino, and leucylglycino hydrate salts of Cu, Ni, and Zn were prepared and their infrared spectra examined A detailed interpretation of the spectra shows a shift in the resonance equilibrium of the peptide group. N-H stretch frequencies are shifted towards lower wave numbers while the C:O bonds shift in the opposite direction.

The article 《The infrared absorption spectra of some amide and dipeptide metal chelates》 also mentions many details about this compound(10466-61-2)Recommanded Product: 10466-61-2, you can pay attention to it, because details determine success or failure

Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 10466-61-2, is researched, SMILESS is N[C@@H](CC(C)C)C(N)=O.[H]Cl, Molecular C6H15ClN2OJournal, Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov’t, Bioorganic & Medicinal Chemistry Letters called LAT1 activity of carboxylic acid bioisosteres: Evaluation of hydroxamic acids as substrates, Author is Zur, Arik A.; Chien, Huan-Chieh; Augustyn, Evan; Flint, Andrew; Heeren, Nathan; Finke, Karissa; Hernandez, Christopher; Hansen, Logan; Miller, Sydney; Lin, Lawrence; Giacomini, Kathleen M.; Colas, Claire; Schlessinger, Avner; Thomas, Allen A., the main research direction is LAT1 carboxylic acid bioisostere hydroxamate; Acyl sulfonamide; Amino acid; SLC7A5; Tetrazole; Transporter inhibitor; Transporter substrate.Application In Synthesis of H-Leu-NH2.HCl.

Large neutral amino acid transporter 1 (LAT1) is a solute carrier protein located primarily in the blood-brain barrier (BBB) that offers the potential to deliver drugs to the brain. It is also up-regulated in cancer cells, as part of a tumor’s increased metabolic demands. Previously, amino acid prodrugs have been shown to be transported by LAT1. Carboxylic acid bioisosteres may afford prodrugs with an altered physicochem. and pharmacokinetic profile than those derived from natural amino acids, allowing for higher brain or tumor levels of drug and/or lower toxicity. The effect of replacing phenylalanine’s carboxylic acid with a tetrazole, acylsulfonamide and hydroxamic acid (HA) bioisostere was examined Compounds were tested for their ability to be LAT1 substrates using both cis-inhibition and trans-stimulation cell assays. As HA-Phe demonstrated weak substrate activity, its structure-activity relationship (SAR) was further explored by synthesis and testing of HA derivatives of other LAT1 amino acid substrates (i.e., Tyr, Leu, Ile, and Met). The potential for a false pos. in the trans-stimulation assay caused by parent amino acid was evaluated by conducting compound stability experiments for both HA-Leu and the corresponding Me ester derivative The authors concluded that HA’s are transported by LAT1. In addition, the results lend support to a recent account that amino acid esters are LAT1 substrates, and that hydrogen bonding may be as important as charge for interaction with the transporter binding site.

The article 《LAT1 activity of carboxylic acid bioisosteres: Evaluation of hydroxamic acids as substrates》 also mentions many details about this compound(10466-61-2)Application In Synthesis of H-Leu-NH2.HCl, you can pay attention to it or contacet with the author([email protected]; [email protected]) to get more information.

Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare

Perseo, Giuseppe; Forino, Romualdo; Galantino, Mauro; Gioia, Bruno; Malatesta, Vincenzo; De Castiglione, Roberto published an article about the compound: H-Leu-NH2.HCl( cas:10466-61-2,SMILESS:N[C@@H](CC(C)C)C(N)=O.[H]Cl ).Related Products of 10466-61-2. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:10466-61-2) through the article.

During the hydrogenolytic removal of the benzyl (Bzl) ester from Boc-Asp(OBzl)-Ala-Phe-Ile-Gly-OEt (I, Boc = Me3CO2C) with either hydrogen gas or ammonium formate in the presence of palladium-on-charcoal as catalyst, variable amounts (5-30%) of an unexpected byproduct were obtained. The byproduct was identified as Boc-Asc-Ala-Phe-Ile-Gly-OEt (Asc = aminosuccinyl). The application of field desorption mass spectrometry as a diagnostic tool is reported. The study of this side reaction, carried out on I and two other dipeptide models, showed that: 1) palladium-on-charcoal may induced Asc formation; 2) the contemporary presence of the catalyst and a base (even in trace amounts) greatly increases the byproduct formation; 3) the side reaction is sequence and solvent dependent; 4) the Asc formation is completely prevented by adding a few equivalent of acetic or formic acid. Some mechanistic considerations are reported.

The article 《Side reactions in peptide synthesis. I. Formation of aminosuccinyl derivatives from aspartyl peptides: a known side reaction in unusual conditions》 also mentions many details about this compound(10466-61-2)Related Products of 10466-61-2, you can pay attention to it, because details determine success or failure

Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare

Category: chiral-catalyst. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 2-Ethylpyrazine, is researched, Molecular C6H8N2, CAS is 13925-00-3, about Hydrothermal liquefaction of Nostoc ellipsosporum biomass grown in municipal wastewater under optimized conditions for bio-oil production. Author is Devi, Thangavelu Eswary; Parthiban, Rangasamy.

Microalgae offer numerous potential applications, however the industrial scale-up of algal technol. still remains a challenge due to high production cost. Optimization of growth conditions and integration with waste streams can improve the economic viability of microalgal production systems. This study investigated on the optimal growth conditions of microalgae Nostoc ellipsosporum cultivated in municipal wastewater with the objective of achieving maximum biomass production, nutrient removal efficiency and bio-oil yield. The effect of light intensity, photoperiod, wavelength, aeration and growth media composition were studied. Different formulations of municipal wastewater blended with Fogs nutrient were used as growth medium. Optimization of growth conditions and acclimatization to wastewater enhanced the biomass yield of Nostoc ellipsosporum from 1.42 to 2.9 g L-1, achieving 87.59% of nitrogen removal and 88.31% of phosphate removal from wastewater. Furthermore, hydrothermal liquefaction of biomass produced bio-oil yield of 24.62% at 300°C.

The article 《Hydrothermal liquefaction of Nostoc ellipsosporum biomass grown in municipal wastewater under optimized conditions for bio-oil production》 also mentions many details about this compound(13925-00-3)Category: chiral-catalyst, you can pay attention to it or contacet with the author([email protected]) to get more information.

Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare

Reference of 4-(Hydroxymethyl)-1,3-dioxolan-2-one. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 4-(Hydroxymethyl)-1,3-dioxolan-2-one, is researched, Molecular C4H6O4, CAS is 931-40-8, about Multiscale evaluation of CO2-derived cyclic carbonates to separate hydrocarbons: Drafting new competitive processes. Author is Hernandez, Elisa; Santiago, Ruben; Moya, Cristian; Navarro, Pablo; Palomar, Jose.

Current chem. technologies present a neg. impact on society and environment since they are based on processes that demand large energy and the use organic solvents, entailing relevant carbon footprint. Emerging solvents impose addnl. criteria in the design of new separation technologies. Aiming at addressing favorable solvent properties but also reducing emissions of carbon dioxide, cyclic carbonates are CO2-based synthesizable designer solvents unexplored in the literature. Cyclic carbonates are a new class of tunable compounds with ability to enhance current standards and improve the sustainability of processes. Here a comprehensive and systematic study, covering fundamental and process scale insights, is developed on the use of cyclic carbonates in the most relevant hydrocarbon separations in the literature, namely {n-heptane + toluene}, {cyclohexane + benzene} and {cyclohexane + cyclohexene} by liquid-liquid extraction and extractive distillation A priori COSMO-RS method described the driving interactions between cyclic carbonates and hydrocarbons, whereas COSMO-based/Aspen was used to further inspect phase equilibrium and design liquid-liquid extraction and extractive distillation separation processes, using benchmark industrial solvents (sulfolane and N-formylmorpholine). The favorable process performance starts a new research line to fine-tune cyclic carbonates’ structure, but currently drafting feasible approaches, competitive or even better when compared with conventional solvents.

The article 《Multiscale evaluation of CO2-derived cyclic carbonates to separate hydrocarbons: Drafting new competitive processes》 also mentions many details about this compound(931-40-8)Reference of 4-(Hydroxymethyl)-1,3-dioxolan-2-one, you can pay attention to it, because details determine success or failure

Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Halo-l,4-dioxanes and their derivatives. II. Thermal rearrangement and reactions of 2,3-dichloro-l,4-dioxane》. Authors are Cort, L.A.; Francis, N. R..The article about the compound:2-Chloroethyl acetatecas:542-58-5,SMILESS:CC(OCCCl)=O).Formula: C4H7ClO2. Through the article, more information about this compound (cas:542-58-5) is conveyed.

cf. CA 55, 546g. Thermal rearrangement of 2,3-dichloro-1,4-dioxane (I) to give both 1,2-dichloroethane and glyoxal has been detected, but the extent of this overall rearrangement is very small. Further eases are reported where the dichlorodioxane fails to yield substitution derivatives Reaction with acetanilide, with o-hydroxyacetanilide, and with acetamide yields in each case some 2-chloroethyl acetate.

The article 《Halo-l,4-dioxanes and their derivatives. II. Thermal rearrangement and reactions of 2,3-dichloro-l,4-dioxane》 also mentions many details about this compound(542-58-5)Formula: C4H7ClO2, you can pay attention to it, because details determine success or failure

Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Journal of the Faculty of Agriculture, Hokkaido University called Infrared and mass spectra of α-amino acid amides, Author is Kasai, Takanori; Furukawa, Katsuhisa; Sakamura, Sadao, which mentions a compound: 10466-61-2, SMILESS is N[C@@H](CC(C)C)C(N)=O.[H]Cl, Molecular C6H15ClN2O, Application In Synthesis of H-Leu-NH2.HCl.

α-Amino acid amide hydrochlorides were prepared from the corresponding L-amino acids according to the procedure of J. P. Greenstein and M. Winitz (1961). O-Methyltyrosinamide-HCl was prepared from O-methyltyrosine derived after reaction of N-acetyl-L-tyrosine with dimethylsulfate, followed by hydrolysis. IR spectra were determined on KBr disks. In the IR studies, the carbonyl stretching vibration (amide I) of all α-amino acid amide hydrochlorides except tyrosinamide-HCl and α-aminoisobutyric acid amide-HCl were in the normal range (1680 ∼1670 cm-1). In the mass spectra, the M+ ion was observed only for methioninamide-HCl, and a very weak M+ + 1 ion was seen for all compounds except aspartic acid diamide.

The article 《Infrared and mass spectra of α-amino acid amides》 also mentions many details about this compound(10466-61-2)Application In Synthesis of H-Leu-NH2.HCl, you can pay attention to it, because details determine success or failure

Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Action of thionyl chloride on the pyridinemonocarboxylic acids》. Authors are Meyer, Hans; Graf, Roderich.The article about the compound:4-Hydroxypicolinic acidcas:22468-26-4,SMILESS:O=C(O)C1=NC=CC(O)=C1).Application of 22468-26-4. Through the article, more information about this compound (cas:22468-26-4) is conveyed.

M. and others had obtained by the action of SOCl2 on pyridinecarboxylic acids substances having the properties of acid chlorides but which, because of their abnormally high m. ps. were thought to be polymers, while Späth and Spitzer (C, A. 20, 3294) later obtained products with normally low m. ps. A renewed study of the reaction has now revealed the cause of the discrepancy. If the treatment of picolinic acid (I) with SOCl2 is not too prolonged there is obtained almost exclusively the normal low-melting chloride (II) but if it is continued longer nucleus chlorination also takes place, especially at high temperatures Nicotinic (III) and isonicotinie acids (IV) are not appreciably halogenated in the nucleus at the b. p. of SOCl2 but do yield chlorinated derivatives when heated in sealed tubes. If the crude II, still containing SOCl2, is kept in vacuo over KOH the originally liquid mass gradually changes into the high-melting product previously thought to be the polymer but which is really II. HCl and finally changes into I.HCl. This change into II.HCl occurs only in the presence of traces of H2O. The conversion of II.HCl into I.HCl is at first very rapid but gradually becomes slower and slower so that the resulting mixture shows for many hrs. an almost constant Cl content, the presence of I.HCl being thereby masked. As in the earlier experiments fresh products were used for the preparation of the amide and esters while the analyses were made only after they no longer gave off penetrating vapors it is easy to understand why the error as to their true nature was made. The admixed SOCl2 can readily be removed completely in vacuo but the now completely S-free products still evolve for a long time penetrating vapors which, however, do not originate in an excess of SOCl2 still present but represent the HCl set free in the change of II.HCl into I.HCl. III and IV behave in the same way but the change of the chloride HCl salts into the acid HCl salts is materially slower. Sublimed II, prepared according to Späth and Spitzer, m. 46°, gives 80% of the amide with NH3, is stable in C6H6 even in the light or in scaled tubes at 100° but in the crystalline form changes in a few hrs. into a green-black mass even if protected from light and air. II.HCl, readily obtained from II in C6H6 with HCl, is a powdery precipitate which, when heated under the supernatant fluid in a scaled vessel until dissolved and allowed to cool slowly, seps. in leaflets, whereas on heating in an open dish it loses HCl and changes into I.HCl; it is extraordinarily hygroscopic and rapidly decomposes in the air into I.HCl and HCl, but when protected from the air it can be kept for months without appreciable change; in a scaled capillary it m. 118-22° (decomposition). Chloride of III, best prepared by refluxing its HCl salt 3 days in SOCl2, b12 85°, m. 15-6°. Chloride of IV, b. 100° in the vacuum of a H2O pump, m, 15-6°. 4-Chloropicolinic acid (V) (30-40% from 10 g. I.HCl boiled in 30 cc. SOCl2 until dissolved, and then heated 20 hrs. at 100°, the resulting HCl salt being decomposed with boiling H2O) m. 182° (decomposition); its NH4 salt with concentrated NH4OH at 180° gives aminopicolinic acid, m. 260° (decomposition) (isolated through the light violet Cu salt), which above its m. p. loses CO2 and yields quant. 4-C5H4NNH2, m. 157-8°, while on diazotization it yields 4-hydroxypicolinic acid, m. 254-5° with evolution of CO2 and formation of 4-C5H4NOH, m. 65-6°. Chloride of V, m. 46°, can be distilled in vacuo without decomposition Me ester, m. 57-8°. Ph ester, m. 68°. Amide, m. 158°. 4,6-Dichloropicolinic acid (VI) (35% from 5 g. V and 15 cc. SOCl2 heated 50 hrs. at 180°), needles (from dilute solution) or leaflets (from concentrated solution) with 1H2O, m. 96-7°, sublimes in anhydrous spears, m. 111-2°, loses HCl at 160-70° and changes into a solid which melts very much higher with decomposition V refluxed in HI (b. 127°) with red P gives a basic 4-iodopicolinic acid-HI (VII), C12H9O4N2I3, m. 185-90°, converted in hot H2O by an excess of freshly precipitated AgCl into the free acid (18 g. from 12 g. V), m. 169° (decomposition); Me ester, m. 75-6°. VI boiled with HI (d. 1.7) and red P gives VII. Me ester of VI, m. 73-4°. Amide, m. 172-4°. 3(5),4,6,-Trichloropicolinic acid is obtained as a by-product in the preparation of VI; its Me ester m. 122-3°. 5-Chloronicotinic acid, m. 171° is obtained in very small yield from III.HCl with SOCl2 at 180°, followed by saponification with boiling H2O; chloride, b12 120°, m. 53°; Me ester, m. 88-9°; Ph ester, m. 79°; amide, m. 205-6°. The NH4 salt with NH4 salt with NH4OH and CuO at 180° yields 5-aminonicotinicotinic acid (Me ester, m. 137°) which above its m. p. forms 3-C6H4NNH2. 5,6-Dichloronicotinic acid (30% from III.HCl heated 50 hrs. with SOCl2 at 150°), needles with 1H2O, m. (anhydrous) 161-2°, resolidifies a few degrees higher and m. again about 300° (decomposition); boiled a long time in excess of KOH or with moderately concentrated H2SO4 it gives the 5-chloro-6-hydroxy acid, m. 305° (incipient decomposition). From. IV and SOCl2 at 180-220° are obtained 3-chloroisonicotinic acid (VII), m. 235° (sealed capillary) (Me ester, m. 32°), and 3,5-dichloroisonicotinic acid (VIII), m. 218.20°, sublimes without decomposition in vacuo. 3-Hydroxyisonicotinic acid, from VII in boiling 50% KOH, yellowish, m. 312°. VIII heated 20 hrs. at 230° yields 3,5-dichloropyridine (IX), m. 64-5°, has an intense odor and is extraordinarily volatile; it was also synthesized from 5-chloronicotinic acid through the Me ester, hydrazide (m. 178°), urethan and 3,5-C5H3N(NH2)Cl. 2,5-Dichloropyridine, from Me isocinchomeronate through 2,5-C5H3N(NH2)2 treated in concentrated HCl with NaNO2 and Cu2Cl2, extremely volatile, m. 60°, depresses the m. p. of IX more than 20°.

The article 《Action of thionyl chloride on the pyridinemonocarboxylic acids》 also mentions many details about this compound(22468-26-4)Application of 22468-26-4, you can pay attention to it, because details determine success or failure

Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Esan, Akintomiwa Olumide; Adeyemi, Ayodele Dorcas; Ganesan, Shangeetha researched the compound: 4-(Hydroxymethyl)-1,3-dioxolan-2-one( cas:931-40-8 ).HPLC of Formula: 931-40-8.They published the article 《A review on the recent application of dimethyl carbonate in sustainable biodiesel production》 about this compound( cas:931-40-8 ) in Journal of Cleaner Production. Keywords: dimethyl carbonate sustainable biodiesel production review. We’ll tell you more about this compound (cas:931-40-8).

Major environmental concerns associated with climate change due to excessive carbon dioxide emissions have mandated the utilization of non-fossil fuels for a more sustainable environment. One of the widely recognized non-fossil fuel is biodiesel which has numerous advantages over fossil fuel. Major issues arising with biodiesel production is the expensive nature of the process which has hindered its sustainability. A suitable way of maximizing the economics of the production process is to avoid glycerol production which has become of low economic value due to its being over-surplus in the chem. industry market. The use of di-Me carbonate (DMC) makes this possible with the production of glycerol carbonate (GC) which ensures a profitable biodiesel production process. This review discusses the various ways in which DMC has been used in biodiesel production, starting from its usefulness in in-situ transesterification and extraction processes to its application in supercritical and non-supercritical transesterification processes. It also investigates the recent coupling transesterification reaction and glycerol carbonate production processes involving DMC. There is the need for a detailed technoeconomic anal. of DMC-biodiesel to validate its economic potential in terms of production cost as well as ascertaining the efficiency and quality of the DMC-biodiesel in diesel engines.

The article 《A review on the recent application of dimethyl carbonate in sustainable biodiesel production》 also mentions many details about this compound(931-40-8)HPLC of Formula: 931-40-8, you can pay attention to it, because details determine success or failure

Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare

Formula: C6H8N2. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 2-Ethylpyrazine, is researched, Molecular C6H8N2, CAS is 13925-00-3, about Characterization of Key Odorants in Moroccan Argan Oil by Aroma Extract Dilution Analysis. Author is Sevindik, Onur; Amanpour, Asghar; Tsouli Sarhir, Salwa; Kelebek, Hasim; Selli, Serkan.

The aroma-active compounds of Moroccan argan oil are sensorily and instrumentally analyzed via gas chromatog.-mass spectrometry-olfactometry (GC-MS-O). The purge and trap extraction (PTE) method is used for the extraction of volatile components. A total of 35 aroma compounds are determined including mostly alcs. and pyrazines, and some carboxylic acids, pyrroles, furans, lactones, volatile phenols, an aldehyde, and a ketone. An aroma extract dilution anal. of the aromatic fraction of argan oil isolated by the PTE method reveals 19 key odorants with flavor dilution (FD) factors ranging from 4 to 512, among which nonanal, 2,5-dimethyl-3-ethylpyrazine and 2,3-diethyl-5-methylpyrazine show the highest FD factors of 512. As for the principal scents perceived by all panelists, characteristic odor notes in argan oil are found to be roasty, nutty, fatty, earthy, and cheesy. Practical Applications: Nut oil is one of the most widely consumed oils in many countries. The outcomes of this investigation provide valuable information for elucidation of the key odorants and aroma composition of the well-known and expensive Moroccan argan oil. Aroma is a crucial quality parameter of a foodstuff which directly influences customer preferences. Therefore, determining the key odorants of argan oil’s aromatic extract isolated by purge and trap methodol. is of major importance for the argan oil sector. The purge and trap extraction set for separation followed by anal. and characterization of those compounds via gas chromatog.-mass spectrometry-olfactometry (GC-MS-O) is an effective practical application tool for aroma description in valuable and expensive oil samples. It is observed that the characteristic odor notes of argan oil are related to the few most powerful aroma-active compounds using the aroma extract dilution anal. technique. The aroma-active compounds of Moroccan argan oil are sensorily and instrumentally analyzed via gas chromatog.-mass spectrometry-olfactometry (GC-MS-O). The purge and trap extraction (PTE) method is used for the extraction of volatile components. A total of 19 aroma compounds are detected as aroma active by AEDA method among 35 volatiles. Characteristic odor notes in argan oil are found to be roasty, nutty, fatty, earthy, and cheesy.

The article 《Characterization of Key Odorants in Moroccan Argan Oil by Aroma Extract Dilution Analysis》 also mentions many details about this compound(13925-00-3)Formula: C6H8N2, you can pay attention to it, because details determine success or failure

Reference:
Chiral Catalysts,
Chiral catalysts – SlideShare