Tag: M.W:300-400

Name is 1,3-Dimesityl-1H-imidazol-3-ium chloride, as a common heterocyclic compound, it belongs to chiral-catalyst compound, and cas is 141556-45-8, its synthesis route is as follows.,141556-45-8

Under the protection of nitrogen, to the reaction tube is sequentially added imidazole salt IMes¡¤HCl (1.1mmol), palladium chloride (1.0mmol), potassium carbonate (2.2mmol), tetrahydrofuran (5.0 ml) and isoquinoline (2.0mmol). The mixture is placed in the oil bath heated reaction (80 C) 12 hours. Stopping the reaction, cooling to room temperature, pressure reducing turns on lathe does solvent, rapid column chromatography separation to obtain a yellow solid product 0.0927g, yield 76%.

With the complex challenges of chemical substances, we look forward to future research findings about 1,3-Dimesityl-1H-imidazol-3-ium chloride

Reference£º
Patent; Wenzhou University; Shao Lixiong; Lu Jianmei; Liu Feng; (23 pag.)CN106892945; (2017); A;,
Chiral Catalysts
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.173035-10-4,1,3-Dimesityl-4,5-dihydro-1H-imidazol-3-ium chloride,as a common compound, the synthetic route is as follows.

A mixtureof 2,4,6-trimethylaniline (11.9 g, 0.088 mol), triethyl orthoformate (7.1 g, 0.048 mol)and acetic acid (0.12 mL) was heated at reflux (?120 ) for 5 h. The mixture wasevaporated until dry under reduced pressure. A mixture of dichloroethane (25 mL)and diisopropylethylamine (8.9 mL, 0.05 mol) was added to the precipitate and afterthat the suspension was stirred at 120 for 5 h in a hermetically sealed Schlenkflask. The formed solution was evaporated to dryness under reduced pressure. Theobtained precipitate was washed with acetone (85 mL) and dried under vacuum at rt.The residue was dissolved in chloroform (300 mL) at 0 C, and then granulatedNaOH (68.0 g, 1.70 mol, with a pellet diameter of ?0.5 mm) was added in one portionto the solution at the same temperature under vigorous stirring. Stirring wascontinued until the temperature reaches 18 C (?40 min), then the reaction wasstirred at this temperature for another 4 h (until the end of the heat release process).The precipitate (NaOH) was filtered off, washed with chloroform (2 ¡Á 40 mL) andhexane (2 ¡Á 40 mL). After the last operation, sodium hydroxide can be used onemore time in the same step. The filtrate was evaporated under reduced pressure.The solid residue was treated with hexane (70 mL) under ultrasonic irradiation for 10min and then held at 4 C for 24 h. The precipitate was filtered off, suspended withmethanol (60 mL), treated by ultrasonic irradiation for 2 min and filtered off. The lastoperation was repeated three more times, after that the white powder was driedunder vacuum at rt to give 14.3 g of the title compound 9 (87% relative to the starting2,4,6-trimethylaniline) with >95% purity (by 1H NMR)., 173035-10-4

173035-10-4 1,3-Dimesityl-4,5-dihydro-1H-imidazol-3-ium chloride 2734917, achiral-catalyst compound, is more and more widely used in various fields.

Reference£º
Article; Polyanskii, Kirill B.; Alekseeva, Kseniia A.; Raspertov, Pavel V.; Kumandin, Pavel A.; Nikitina, Eugeniya V.; Gurbanov, Atash V.; Zubkov, Fedor I.; Beilstein Journal of Organic Chemistry; vol. 15; (2019); p. 769 – 779;,
Chiral Catalysts
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As a common heterocyclic compound, it belongs to quinuclidine compound,Quinuclidine-4-carboxylic acid hydrochloride,40117-63-3,Molecular formula: C8H14ClNO192,mainly used in chemical industry, its synthesis route is as follows.,14098-24-9

General procedure: The carbonyl substrate (0.1 g) is dissolved in 1-2 mL of anhydrous CHCl3 and 2.0 equiv of a benzocrown ether is added to the solution. To this mixture, CF3SO3H (8.0 equiv; H2SO4 may be used in some cases) is added dropwise with stirring. The reaction is stirred at room temperature for at least 2 h, after which, the mixture is poured over several grams of ice. The resulting solution is extracted three times with CHCl3. The organic phase is subsequently washed three times with water and dried over MgSO4 solution. Removal of the solvent provides the product.

With the complex challenges of chemical substances, we look forward to future research findings about Benzo-18-crown 6-Ether,belong chiral-catalyst compound

Reference£º
Article; Zielinski, Matthew E.; Tracy, Adam F.; Klumpp, Douglas A.; Tetrahedron Letters; vol. 53; 14; (2012); p. 1701 – 1704;,
Chiral Catalysts
Chiral catalysts – SlideShare

1,3-Dimesityl-1H-imidazol-3-ium chloride, cas is 141556-45-8, it is a common heterocyclic compound, the chiral-catalyst compound, its synthesis route is as follows.,141556-45-8

General procedure: A mixture of pyrazine ligand 1 or 2 (1mmol), Li2PdCl4 (1mmol) and NaOAc (1mmol) in 20mL of dry methanol was stirred for 24hat rt. The yellow solids (yield: 92%) were collected by filtration and washed several times with methanol, which can be assigned to be palladacyclic dimers. Then, a Schlenk tube was charged with the above chloride-bridged palladacyclic dimers (0.5mmol), the corresponding imidazolium salt (1.25mmol) and tBuOK (2.5mmol) under nitrogen. Dry THF was added by a cannula and stirred at room temperature for 3h. The product was separated by passing through a short silica gel column with CH2Cl2 as eluent, the third band was collected and afforded the corresponding carbene adducts 3-10 as yellow solids. The characterization data for 3: Yield: 78%.

As the rapid development of chemical substances, we look forward to future research findings about 141556-45-8

Reference£º
Article; Xu, Chen; Wang, Zhi-Qiang; Fu, Wei-Jun; Ji, Bao-Ming; Yuan, Xiao-Er; Han, Xin; Xiao, Zhi-Qiang; Hao, Xin-Qi; Song, Mao-Ping; Journal of Organometallic Chemistry; vol. 777; (2015); p. 1 – 5;,
Chiral Catalysts
Chiral catalysts – SlideShare

141556-45-8, 1,3-Dimesityl-1H-imidazol-3-ium chloride is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Under the protection of nitrogen, to the reaction tube is sequentially added imidazole salt IMes¡¤HCl (1.1mmol), palladium chloride (1.0mmol), potassium carbonate (2.2mmol), tetrahydrofuran (5.0 ml) and isoquinoline (2.0mmol). The mixture is placed in the oil bath heated reaction (80 C) 12 hours. Stopping the reaction, cooling to room temperature, pressure reducing turns on lathe does solvent, rapid column chromatography separation to obtain a yellow solid product 0.0927g, yield 76%.

141556-45-8, As the paragraph descriping shows that 141556-45-8 is playing an increasingly important role.

Reference£º
Patent; Wenzhou University; Shao Lixiong; Lu Jianmei; Liu Feng; (23 pag.)CN106892945; (2017); A;,
Chiral Catalysts
Chiral catalysts – SlideShare

173035-10-4, 1,3-Dimesityl-4,5-dihydro-1H-imidazol-3-ium chloride is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Complex 1e was synthesized similarly as reported for the(5-C5Me5) complex by Ritleng et al. [4e]. A hexane solution ofn-BuLi (2.5 mL, 5.1 mmol) was added to a THF (5 mL) solution of1,3-bis(1,1-dimethylbut-3-enyl)cyclopentadiene (4.83 mmol). Theresulting mixture was stirred for 2 h at ambient temperature. Thissolution was added to a solution of [Ni(acac)2] (1.199 g, 4.67 mmol)in THF (10 mL) at -78C. The color changed immediately fromgreen to red and a suspension of 1,3-dimesitylimidazolinium chlo-ride [12] (1.693 g, 4.96 mmol) in THF (10 mL) was quickly added atthis temperature. The reaction mixture was allowed to warm up to ambient temperature and stirred for a further 2 h. The volatileswere removed under reduced pressure. The solid residue wasextracted with hexane (20 mL) and filtered through Celite. Com-plex 1e was isolated by crystallization as a red, microcrystallinesolid. Yield: 2.40 g (3.82 mmol, 79%).1H NMR (CDCl3, 400 MHz) (ppm) = 7.04 (s, 4H, Ar), 5.51-5.62 (m, 2H, CH ), 4.88-4.90 (m,4H, CH2), 4.14 (s, 1H, C5H3), 3.82 (s, 4H, NCH2), 3.62 (s, 2H,C5H3), 2.37 (s, 12H, o-CH3), 2.35 (s, 6H, p-CH3), 2.01 (m, 2H, CH2),1.84 (m, 2H, CH2), 0.85 (s, 6H, CH3), 0.71 (s, 6H, CH3).13C{1H}NMR (CDCl3, 101 MHz) (ppm) = 204.0 (NCN), 138.3 ( CH ) 137.8,137.2, 136.4, 132.1, 129.9 (Ar and C5H3), 116.1 ( CH2), 91.2 (C5H3),76.5 (C5H3), 51.25 (NCH2), 49.00 (CH2), 33.40 (C(CH3)2), 28.84,26.39 (CH3), 21.02, 18.80 (o- and p-CH3). MS (EI, 70 eV) m/z (rel.int.%) (58Ni) 628 (M+, 10), 516 (M+-C8H16, 26), 361 (M+-C20H27,100). HRMS (EI) for C38H51N235Cl58Ni: calc. 628.30942, found628.30983. C38H51N2ClNi Calc. (%) C 72.45, H 8.15, N 4.44, foundC 72.41, H 8.08, N 4.38. Crystals suitable for X-ray measurementwere grown from a concentrated solution in n-heptane/THF at 4C., 173035-10-4

173035-10-4 1,3-Dimesityl-4,5-dihydro-1H-imidazol-3-ium chloride 2734917, achiral-catalyst compound, is more and more widely used in various fields.

Reference£º
Article; Buchowicz, W?odzimierz; Conder, Joanna; Hryciuk, Dymitr; Zachara, Janusz; Journal of Molecular Catalysis A: Chemical; vol. 381; (2014); p. 16 – 20;,
Chiral Catalysts
Chiral catalysts – SlideShare

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.173035-10-4,1,3-Dimesityl-4,5-dihydro-1H-imidazol-3-ium chloride,as a common compound, the synthetic route is as follows.

Synthesis of [(SIMes)CuCl]. This synthesis is as reported in the literature; see S. Diez-Gonzalez et al., J. Org. Chem. 2005, 70, 4784-4796. In a 250 mL Schlenk flask were added copper(I) chloride (1.0 g, 10.10 mmol), 1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydro-imidazol-2-ylidenium chloride (SIMes-HCl, 10.10 mmol), and sodium tert-butoxide (0.97 g, 10.10 mmol). To this flask, dry tetrahydrofuran (100 mL) was added under an inert atmosphere of argon, and the mixture was magnetically stirred for 20 hours at room temperature. After the mixture was filtered through a plug of Celite and then evaporating the solvent under vacuum, a white solid was obtained. 1H NMR (400 MHz, CDCl3) delta=6.96 (s, 4H), 3.96 (s, 4H), 2.32 (s, 12H), 2.30 (s, 6H); 13C NMR (100 MHz, CDCl3) delta=202.8, 138.7, 135.3, 135.0, 129.7, 50.9, 21.0, 18.0. Elemental analysis calcd for C21H26CuClN2: C, 62.21; H, 6.46; N, 6.91. Found: C, 62.60; H, 6.52; N, 6.80%., 173035-10-4

As the paragraph descriping shows that 173035-10-4 is playing an increasingly important role.

Reference£º
Patent; Institut Catala d’Investigacio Quimica; Institucio Catalana de Recerca i Estudis Avancats; US2009/69569; (2009); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare

173035-10-4, 1,3-Dimesityl-4,5-dihydro-1H-imidazol-3-ium chloride is a chiral-catalyst compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Synthesis of [(SIMes)CuBr]. In an oven-dried vial, copper(I) bromide (0.522 g, 3.63 mmol), SIMes.HCl (0.86 g, 2.52 mmol) and sodium tert-butoxide (0.243 g, 2.52 mmol) were loaded inside a glovebox and stirred in dry THF (18 mL) overnight at room temperature outside of the glovebox. After filtration of the reaction mixture through a plug of Celite, the filtrate was mixed with hexane to form a precipitate. A second filtration afforded 0.808 g (71% yield) of the title complex as an off-white solid.Spectroscopic and analytical data for [(SIMes)CuBr]: 1H NMR (300 MHz, [D6]acetone): delta=7.01 (s, 4H, HAr), 4.16 (s, 4H, NCH2), 2.37 (s, 12H, ArCH3), 2.29 (s, 6H, ArCH3); 13C NMR (75 MHz, CDCl3): delta=202.6 (C, NCN), 138.5 (C, CAr), 135.3 (CH, CAr), 135.0 (C, CAr), 129.7 (CH, CAr), 51.0 (CH2, NCH2), 21.0 (CH3, ArCH3), 18.0 (CH3, ArCH3); Elemental analysis calcd for C21H26BrCuN2 (449.89): C, 56.06; H, 5.83; N, 6.23. Found: C, 55.98; H, 5.64; N, 6.21%., 173035-10-4

The synthetic route of 173035-10-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Institut Catala d’Investigacio Quimica; Institucio Catalana de Recerca i Estudis Avancats; US2009/69569; (2009); A1;,
Chiral Catalysts
Chiral catalysts – SlideShare

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.173035-10-4,1,3-Dimesityl-4,5-dihydro-1H-imidazol-3-ium chloride,as a common compound, the synthetic route is as follows.

Add ligand L3343mg (1.0mmol), copper powder 192mg (3.0mmol), 20 mL of water in a 50mL flask, 70 ~ 80 oil bath, the reaction was stirred for 20 hours, the reaction mixture was cooled to room temperature, filtered, the filter cake was washed 3 times with water, the filter cake dissolved in acetonitrile and filtered to remove unreacted copper powder, the solvent was evaporated under reduced pressure to give 199mg as colorless crystals, a yield of 49%

173035-10-4, As the paragraph descriping shows that 173035-10-4 is playing an increasingly important role.

Reference£º
Patent; China Petroleum & Chemical Corporation Shanghai Research Institute of Petrochemical.; Liu, Bo; Jin, Zhaosheng; Lu, Jiangang; Li, Xianming; Zhou, Haichun; (13 pag.)CN105585584; (2016); A;,
Chiral Catalysts
Chiral catalysts – SlideShare

Benzo-18-crown 6-Ether, cas is 14098-24-9, it is a common heterocyclic compound, the chiral-catalyst compound, its synthesis route is as follows.

General procedure: A modification of the previously reported procedure23 was used. Commercially available Eaton’s reagent (ca. 8 ml that corresponds to 6.28 mmol of phosphorus(V) oxide) and acetic acid (0.20 ml, 3.45 mmol) were mixed at room temperature. Then naphtho-15-crown-5 ether (1 g, 3.14 mmol) was added. The reaction mixture was stirred at room temperature for ca. 6 h and then poured into water. The suspension was extracted with dichloromethane and the combined organic phases were washed with water. Removal of the dried (MgSO4) solvent gave a dark brown oil, which upon repeated extractions with hot heptane, afforded the product as an off-white solid (1.02 g, 90%), mp 126-129 C.

14098-24-9, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,14098-24-9 ,Benzo-18-crown 6-Ether, other downstream synthetic routes, hurry up and to see

Reference£º
Article; Paramonov, Sergey V.; Lokshin, Vladimir; Smolentsev, Artem B.; Glebov, Evgeni M.; Korolev, Valeri V.; Basok, Stepan S.; Lysenko, Konstantin A.; Delbaere, Stephanie; Fedorova, Olga A.; Tetrahedron; vol. 68; 38; (2012); p. 7873 – 7883;,
Chiral Catalysts
Chiral catalysts – SlideShare