Reference of H-Leu-NH2.HCl. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: H-Leu-NH2.HCl, is researched, Molecular C6H15ClN2O, CAS is 10466-61-2, about Total synthesis of the cyclopeptide alkaloid abyssenine A. Application of inter- and intramolecular copper-mediated coupling reactions in organic synthesis. Author is Toumi, Mathieu; Couty, Francois; Evano, Gwilherm.
The total synthesis of the 15-membered ring cyclopeptide alkaloid abyssenine A (I) has been achieved with a longest linear sequence of 15 steps. Central to the synthetic approach was an efficient copper-mediated Ullmann coupling/Claisen rearrangement sequence allowing for both ipso and ortho functionalization of aromatic iodide. This sequence was used for the synthesis of the aromatic core. The synthetic utility of copper-catalyzed coupling reactions was further demonstrated to install the enamide with a concomitant straightforward macrocyclization starting from acyclic α-amido-ω-vinyl iodide.
Compound(10466-61-2)Reference of H-Leu-NH2.HCl received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(H-Leu-NH2.HCl), if you are interested, you can check out my other related articles.