One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 80657-57-4, Name is (S)-Methyl 3-hydroxy-2-methylpropanoate, formurla is C5H10O3. In a document, author is Ge, Yicong, introducing its new discovery. Product Details of 80657-57-4.
A novel [4+1] spiroannulation ofo- &p-bromophenols with alpha,beta-unsaturated imines has been developed for the direct synthesis of a new family of azaspirocyclic molecules. Notably, several other halophenols (X=Cl, I) were also applicable for this transformation. Moreover, a catalytic asymmetric version of the reaction was realized with 1-bromo-2-naphthols by using a chiral Sc-III/Py-Box catalyst. Mechanistic studies revealed that this domino reaction proceeded through electrophile-triggered dearomatization of phenol derivatives at their halogenated positions and followed by halogen-displacement withN-nucleophiles via a radical-based S(RN)1 mechanism.
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Reference:
Chiral Catalysts,
,Chiral catalysts – SlideShare